Make a macroring in half a day instead of several months

Make a macroring in half a day instead of several months. 

INTRODUCTION

Macrocycles are not only esthetically pleasing, but they also can contain multiple functional groups. They are, however, difficult to synthesize. For example, preparing sterically crowded, circularly folded aromatic pentamer 1 required a months-long step-by-step process; and it was obtained in an overall yield of only ≈5%

(Qin, B., et al. Org. Lett. 2008, 10, 5127–5130).

The task is much easier now; it can be accomplished in half a day by using a synthetic route developed by H. Zeng and coauthors at the National University of Singapore, Guang Dong University of Technology (China), and Nanyang Technological University (Singapore).

 One-pot, multi-molecular macrocyclization allows the highly selective preparation of pentagon-shaped circular aromatic pentamers mediated by an inward-pointing continuous hydrogen-bonding network.

The protocol is based on a hydrogen-bonding–assisted, one-pot macrocyclization reaction. In the presence of coupling reagent POCl3 and organic base Et3N, 3-amino-2-methoxybenzoic acid (2) undergoes self-amidation under mild conditions to give 1 in a high yield (46%) after a 12-h reaction time. The versatility of this highly selective macrocyclization reaction is illustrated by synthesizing derivatives of 2 with various substituents at the 2- and 5-positions. (Chem. Commun. 2011, 47, 5419–5421;

 http://pubs.rsc.org/en/content/articlelanding/2011/CC/C0CC05791F#!divAbstract

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Detecting Thrombosis

A magnetic resonance (MR) probe can be used to distinguish old and new blood clots

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Studies of Removal of Indigo Caramine Dye from Water by Formaldehyde and Urea Treated Cellulosic Waste of Citrus reticulata Peels

 Citrus reticulata, Orange


Studies of Removal of Indigo Caramine Dye from Water by Formaldehyde and Urea Treated Cellulosic Waste of Citrus reticulata Peels



Asian J. Chem., 2014, 26(1), pp 43-47   |  DOI:10.14233/ajchem.2014.15305

Rabia Rehman*, Javaria Zafar and Hina Nisar

Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan

*Corresponding author: Fax: +92 42 99230998; 

Tel: +92 42 99230463, Ext: 870; E-mail: grinorganic@yahoo.com

The Citrus reticulata (orange) peels has been employed as adsorbents for removing inorganic and organic pollutants from wastewater extensively due to its low cost and eco-friendly nature. This research work concerns with the study of comparative removal of Indigo carmine dye from water using simple, formaldehyde and urea treated Citrus reticulata peels. The effect of adsorption parameters were investigated and maximum sorption capacity was obtained from Langmuir isotherm model at optimized conditions, i.e.: 5.90, 14.79 and 71.07 mg g-1 for simple, formaldehyde treated and urea treated Citrus reticulata peels, respectively. 

Feasibility of process is indicated by the values of separation factor, Gibb’s free energy and adsorption intensity ‘n’. The results of present study indicate that Citrus reticulata peels has inherited a lots of capacity for removing anthraquinone type of dyes, which can be further improved by treating with formaldehyde or urea in economical way.

View Article 

http://www.asianjournalofchemistry.co.in/User/ViewFreeArticle.aspx?ArticleID=26_2_12

Asian Journal of Chemistry

AN INTERNATIONAL PEER REVIEWED RESEARCH JOURNAL OF CHEMISTRY

Inst of Chem Eng , Univ of punjab, Pakistan




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INST OF CHEMISTRY, UNIV OF PUNJAB LAHORE PAKISTAN




University of the Punjab, Lahore, Pakistan-54590


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Natural product based leads to fight against leishmaniasis

The growing incidence of parasitic resistance against generic pentavalent antimonials, specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania control. Notwithstanding the two treatment alternatives, that is amphotericin B and miltefosine are being effectively used but their high cost and therapeutic complications limit their use in endemic areas. In the absence of a vaccine candidate, identification, and characterization of novel drugs and targets is a major requirement of leishmanial research. This review describes current drug regimens, putative drug targets, numerous natural products that have shown promising antileishmanial activity alongwith some key issues and strategies for future research to control leishmaniasis worldwide

Natural product based leads to fight against leishmaniasis

 Review Article

Bioorganic & Medicinal Chemistry,Volume 22, Issue 1, 1 January 2014, Pages 18–45

Nisha Singh, Bhuwan B. Mishra, Surabhi BajpaiRakesh K. Singh, Vinod K. Tiwari
Molecular Immunology Laboratory, Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India , Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India 

http://www.sciencedirect.com/science/article/pii/S0968089613009887, 

VARANASI INDIA

New Organic Conjugated Molecules

A series of organic conjugated molecules containing 2,3-benzopyridiazine and thiophene derivatives has been synthesized

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Anti-Markovnikov Hydrohydrazination

A rhodium-based catalyst reverses regioselectivity in the production of hydrazones

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Anti-Markovnikov Hydrohydrazination

Selection of boron reagents for Suzuki–Miyaura coupling

 Suzuki–Miyaura (SM) cross-coupling is arguably the most widely-applied transition metal catalysed carbon–carbon bond forming reaction to date. Its success originates from a combination of exceptionally mild and functional group tolerant reaction conditions, with a relatively stable, readily prepared and generally environmentally benign organoboron reagent. A variety of such reagents have been developed for the process, with properties that have been tailored for application under specific SM coupling conditions. This review analyses the seven main classes of boron reagent that have been developed. The general physical and chemical properties of each class of reagent are evaluated with special emphasis on the currently understood mechanisms of transmetalation. The methods to prepare each reagent are outlined, followed by example applications in SM coupling.
http://pubs.rsc.org/en/content/articlehtml/2014/cs/c3cs60197h

Review Article

Selection of boron reagents for Suzuki–Miyaura coupling

Alastair J. J. Lennox^a and   Guy C. Lloyd-Jones*^a  

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*

Corresponding authors

^a

School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JJ, UK

Chem. Soc. Rev., 2014,43, 412-443

DOI: 10.1039/C3CS60197H
Received 12 Jun 2013, First published online 03 Oct 2013 

 http://pubs.rsc.org/en/Content/ArticleLanding/2014/CS/c3cs60197h?utm_source=toc-alert&utm_medium=email&utm_campaign=pub-cs-vol-43-issue-1#!divAbstract
 READ AT
 http://pubs.rsc.org/en/content/articlehtml/2014/cs/c3cs60197h
 DOI: 10.1039/C3CS60197H (Review Article) Chem. Soc. Rev. , 2014, 43, 412-443