DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 30 Yrs Exp. in the feld of Organic Chemistry. Serving chemists around the world. Helping them with websites on Chemistry.Millions of hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Friday, 30 May 2014

Visible-light-induced photocatalytic formyloxylation reactions of 3-bromooxindoles with water and DMF: the scope and mechanism

Green Chem., 2014, Advance Article
DOI: 10.1039/C4GC00647J, Paper
You-Quan Zou, Wei Guo, Feng-Lei Liu, Liang-Qiu Lu, Jia-Rong Chen, Wen-Jing Xiao
A highly efficient visible light induced formyloxylation reaction of 3-bromooxindoles was disclosed. Results of labeling experiments indicated that H2O and DMF were incorporated into the terminal 3-formyloxyoxindoles.
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The formyloxylation reaction of 3-bromooxindoles with water and N,N-dimethylformamide (DMF) has been developed in the presence of the photoredox catalyst fac-Ir(ppy)3 under irradiation of visible light at ambient temperature. The reaction provides a straightforward approach to pharmaceutically and synthetically useful 3-formyloxyoxindoles in high yields. The mechanism of this transformation was investigated by fluorescence quenching experiments, “on–off” switching of the light source, labeling experiments, mass spectral analyses and in situ IR experiments.

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Wednesday, 14 May 2014

Sunday, 11 May 2014

A highly efficient approach to vanillin starting from 4-cresol

Green Chem., 2014, 16,2807-2814
DOI: 10.1039/C4GC00003J, Paper
Jian-An Jiang, Cheng Chen, Ying Guo, Dao-Hua Liao, Xian-Dao Pan, Ya-Fei Ji
A highly efficient three-step approach to vanillin has been developed starting from 4-cresol.

A highly efficient approach to the famous flavor and fragrance compound vanillin has been developed starting from 4-cresol with the attention focused on improving the sustainability of all the reactions. The approach involves a three-step sequence of the quasi-quantitative selective clean oxybromination of 4-cresol, the high-yield selective aerobic oxidation of 2-bromo-4-cresol, and the quantitative methoxylation of 3-bromo-4-hydroxybenzaldehyde with the recovery of pure methanol. Herein, the pivotal oxidation and methoxylation reactions are logically investigated and developed into two concise methodologies. As a green alternative, the approach holds significant value for the sustainable manufacturing of vanillin.