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Sunday, 22 July 2012

Citalopram/Escitalopram Oxalate, Isolation & Synthesis of Novel Impurities, Emcure paper


Citalopram  brand names: CelexaCipramil) is an antidepressantdrug of the selective serotonin reuptake inhibitor (SSRI) class. It has U.S. Food and Drug Administration (FDA) approval to treat major depression, and is prescribed off-label for a number of anxiety conditions.

Escitalopram (trade names NexitoAnxiset-E (India), Lexapro,CipralexSeroplexLexamilLexamEntactLosita(Bangladesh) Reposil (Chile)), is an antidepressant of theselective serotonin reuptake inhibitor (SSRI) class. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of adults and children over 12 years of age with major depressive disorder and generalized anxiety disorder. Escitalopram is the (S)-stereoisomer (enantiomer) of the earlier Lundbeck drugcitalopram

Citalopram/Escitalopram Oxalate: Isolation & Synthesis of Novel Impurities

Emcure Pharmaceuticals Ltd, R & D Centre, Pimpri, Pune -411018, India

Abstract Image

During process optimization of Escitalopram oxalate novel impurities, 6 and 7 were observed, which were isolated and characterized, and the proposed structure was confirmed by chemical synthesis. Investigation of the cause of impurities formation improved the yield and purity of the drug product during the bulk API synthesis



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