Suzuki–Miyaura (SM) cross-coupling is arguably the most widely-applied
transition metal catalysed carbon–carbon bond forming reaction to date. Its
success originates from a combination of exceptionally mild and functional group
tolerant reaction conditions, with a relatively stable, readily prepared and
generally environmentally benign organoboron reagent. A variety of such reagents
have been developed for the process, with properties that have been tailored for
application under specific SM coupling conditions. This review analyses the
seven main classes of boron reagent that have been developed. The general
physical and chemical properties of each class of reagent are evaluated with
special emphasis on the currently understood mechanisms of transmetalation. The
methods to prepare each reagent are outlined, followed by example applications
in SM coupling.
http://pubs.rsc.org/en/content/articlehtml/2014/cs/c3cs60197h
Review Article
Show Affiliations
a
School of Chemistry, University of Edinburgh,
West Mains Road, Edinburgh, EH9 3JJ, UK
Chem. Soc.
Rev., 2014,43, 412-443
DOI:
10.1039/C3CS60197H
Received
12 Jun 2013, First published online 03 Oct 2013
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