Natural product based leads to fight against leishmaniasis

The growing incidence of parasitic resistance against generic pentavalent antimonials, specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania control. Notwithstanding the two treatment alternatives, that is amphotericin B and miltefosine are being effectively used but their high cost and therapeutic complications limit their use in endemic areas. In the absence of a vaccine candidate, identification, and characterization of novel drugs and targets is a major requirement of leishmanial research. This review describes current drug regimens, putative drug targets, numerous natural products that have shown promising antileishmanial activity alongwith some key issues and strategies for future research to control leishmaniasis worldwide

Natural product based leads to fight against leishmaniasis

 Review Article

Bioorganic & Medicinal Chemistry,Volume 22, Issue 1, 1 January 2014, Pages 18–45

Nisha Singh, Bhuwan B. Mishra, Surabhi BajpaiRakesh K. Singh, Vinod K. Tiwari
Molecular Immunology Laboratory, Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India , Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India 

http://www.sciencedirect.com/science/article/pii/S0968089613009887, 

VARANASI INDIA