Weygand/Hilgetag Preparative Organic Chemistry

Weygand/Hilgetag Preparative Organic Chemistry

World Drug Tracker: ESCITALOPRAM

World Drug Tracker: ESCITALOPRAM:

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OMICS Publishing Group | Full-text | Chemical Constituents from the Polar Fraction of Rubus suavissimus

OMICS Publishing Group | Full-text | Chemical Constituents from the Polar Fraction of Rubus suavissimus:

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Antioxidant Mechanism of Active Ingredients Separated from Eucalyptus globulus

Antioxidant Mechanism of Active Ingredients Separated from Eucalyptus globulus

N. M. El-Moein, E. A. Mahmoud and Emad A. Shalaby*

Biochemistry Department, Faculty of Agriculture, Cairo University, Giza, Egypt, 12613

*Corresponding author: Emad A. Shalaby Biochemistry Department, Faculty of Agriculture Cairo University, Giza, Egypt Tel: 002-02-01001203313 E-mail: drshalaby@staff.cu.edu.eg

OMICS Publishing Group | Full-text | Antioxidant Mechanism of Active Ingredients Separated from Eucalyptus globulus:

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Iodine-mediated arylation of benzoxazoles with aldehydes - Green Chemistry (RSC Publishing)

Iodine-mediated arylation of benzoxazoles with aldehydes - Green Chemistry (RSC Publishing):

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Fullerenols: Fulfilling our Future Energy Needs

Carbon to catalyze low-carbon, hydrogen economy

read all at

http://www.chemistryviews.org/details/ezine/5132011/Fullerenols_Fulfilling_our_Future_Energy_Needs.html

Synthesis of Tolvaptan

《Chinese Journal of Pharmaceuticals》 2011-02

Synthesis of Tolvaptan

pick up all this at

http://en.cnki.com.cn/Article_en/CJFDTotal-ZHOU201102007.htm

YANG Chuanwei~1,MU Shuai~2,LIU Ying~3,WANG Pingbao~3,LIU Dengke~(3*) 
(1.School of Pharmacy,Henan University,Kaifeng 475004;2.
School of Chemical Engineering and Technology,
 Tianjin University,Tianjin 300072;3.
Tianjin Institute of Pharmaceutical Research,Tianjin 300193)  

Tolvaptan,a selective nonpeptide arginine vasopressin V_2 receptor antagonist,was synthesized
 from 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine by acylation and reduction to give 1-(4-amino-2-methylbenzoyl) -7- chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine,which was subjected to acylation with 2-methylbenzoyl chloride and reduction with sodium borohydride with an overall yield of about 45%.

【Key Words】： tolvaptan arginine vasopressin V_2 receptor antagonist heart failure hyponatremia synthesis
【Fund】： 天津市科技计划项目(09ZCKFSH01300)
【CateGory Index】： R914

 Download(CAJ format)  Download(PDF format) 

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	【Citations】

	Chinese Journal Full-text Database 2 Hits
	1 LI Fan1, HOU Xingpu2, LI Lin1, LU Tao1, DU Yumin1 (1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017; 2. Shijiazhuang  Pharma Group NBP Pharmaceutical Co., Ltd., Shijiazhuang 052160); Synthesis of Antiparkinsonian Agent Istradefylline[J];Chinese Journal of Pharmaceuticals;2010-04 2 YANG Miao~1,SHUAI Jun~2,LIU Mo~3,LIU Deng-ke~(3*),WANG Ping-bao~3 (1.Tianjin Medical University,Tianjin 300070;2.Tianjin University;Tianjin 300072;  3.Tianjin Institute of Pharmaceutical Research,Tianjin 300193); Synthesis of 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine[J]; Chinese Journal of Pharmaceuticals;2009-09

	【Co-citations】

	Chinese Journal Full-text Database 1 Hits
	1 XIONG Xiao-yi,CHEN An-qun,HE Yong-mei(Chongqing Unis Chemical Co.,Ltd.,Chongqing 402161,China);Analysis of Cyanoacetic Acid Content by HPLC[J];Guangzhou Chemical Industry;2010-12