The addition of malonate esters to α,β-unsaturated N-sulfonyl imines has been
reported by a team from Spain Read more
ORGANIC CHEMISTRY INTERNATIONAL............ BY DR ANTHONY MELVIN CRASTO, Helping millions with websites, millions of hits on google. 30 yrs exp in the field of Process development
Showing posts with label MANUFACTURING. Show all posts
Showing posts with label MANUFACTURING. Show all posts
Wednesday 13 November 2013
An Expeditious Route to Chiral δ-Aminoesters and Piperidones
The addition of malonate esters to α,β-unsaturated N-sulfonyl imines has been
reported by a team from Spain Read more
Friday 20 September 2013
Molecular Storage Provides Chlorine and Phosgene Safely
Molecular Storage Provides Chlorine and Phosgene Safely
Photodecomposition of tetrachloroethylene provides a safer source of small chlorinated building blocks for organic synthesisThursday 19 September 2013
Friday 16 August 2013
Multiple Metal-Free Pathways to 2-Acyloxazoles
2-Acyloxazoles can be formed from a variety of different starting materials just by tweaking the iodine oxidant
Multiple Metal-Free Pathways to 2-Acyloxazoles
Resolving Asymmetric Epoxidations
An enantioselective route to form epoxides by using kinetic resolution techniques has been developed
Friday 2 August 2013
Organic Chemistry Becomes Multidisciplinary
18th European Symposium on Organic Chemistry (ESOC 2013) sees future trends in close connection to biology, physics, and materials science
Read more
Sunday 21 July 2013
The first total synthesis of fuscain
First total synthesis of fuscain
Fuscain is a new furanolactam isolated from the sponge Phacellis fusca from the South China Sea. Furan analogues isolated from marine organisms have valuable medicinal properties. The first total synthesis of fuscain is reported in Journal of Chemical Research December issue. The key step in the synthesis is the formation of seven-membered lactam by acylation of a furan ring using the mild Lewis acid CuSO4•5H2O.
Fuscain, a new furanolactam which was originally isolated from the sponge Phacellis fusca collected in South China Sea, showed a moderate cytotoxicity toward P388 and L1210 cell lines. The same sponge yielded three pyrrololactam alkaloids: saldisin, 2-bromoaldisin and debromohymenialdisin.2 Recently, furan analogues isolated from marine organisms have shown anticancer,3–5 antibacterial,6 anticoagulant, antifungal, antimalarial, antiplatelet, antituberculosis and antiviral activities11. Aldisin-based derivatives can be easily synthesised. However, it is still a challenge to synthesise fuscain. Hence the biological effects of fuscain and its derivatives on cell cycle progression and antitumour activities have rarely been reported. The synthetic route to fuscain is shown below.
The key step is an intramolecular Friedel–Crafts cyclisation to form the seven-membered ring. Various Lewis acids (polyphosphoric acid, POCl3, polyphosphoric acid–acetic acid, POCl3–P2O5, TFA or MSA) have been reported for Friedel– Crafts cyclisation.13,14. Initially, we selected PPA and P2O5 as catalysts but no product was obtained. Because of the structural difference between Alidisin and fuscain, the aromaticity of furan ring is less than a pyrrole ring, and a furan ring usually polymerised under acidic conditions, we selected a relatively mild Lewis acid CuSO4•5H2O to complete the intramolecular cyclisation to form fuscain.
Source: Journal of Chemical Research, Volume 36, Number 12, December 2012 , pp. 736-737(2)
doi: 10.3184/174751912X13528167435099
Yuan-wei Liang, Xiao-jian Liao, Chang-jun Wang, Jin-zhi Guo, Shuo Li and Shi-hai Xu*
Department of Chemistry, Jinan University, Guangzhou 510632, P. R. China
Department of Chemistry, Jinan University, Guangzhou 510632, P. R. China
Friday 19 July 2013
A Spontaneous Resolution
Chiral supramolecular fluorophores can be made by simple crystallizationRead more
Friday 12 July 2013
Turning carbon dioxide into something useful -Carbon dioxide reduced to formate by iridium pincer catalyst
http://www.rsc.org/chemistryworld/2013/07/iridium-catalyst-carbon-dioxide-reduction-formate
New research shows that a water-soluble catalyst developed by scientists in the US can electrocatalytically transform carbon dioxide into a useful chemical feedstock.
The global demand for fuel is rising, as are carbon dioxide levels in the atmosphere. Recent studies have attempted to address the global carbon imbalance by exploring ways to recycle carbon dioxide into liquid fuels. Formate, the anion of formic acid, is an intermediate of carbon dioxide reduction and can be used as a fuel in formic acid fuel cells. However, the selective production of formate, without using organic solvents, is challenging. Water, being inexpensive and environmentally-friendly, is obviously preferred over organic solvents as a reaction medium. On the other hand, the reduction of carbon dioxide in water is complicated by the reduction of water to hydrogen being a more kinetically favourable process.
http://www.rsc.org/chemistryworld/2013/07/iridium-catalyst-carbon-dioxide-reduction-formate
Friday 5 July 2013
Chiral Column? Here’s One I (Vikki Cantrill) Made Earlier
Continuous-flow Diels–Alder reactions with a homemade HPLC column give good selectivity for >150 hRead more
http://www.chemistryviews.org/details/news/4972561/Chiral_Column_Heres_One_I_Made_Earlier.html
Valerio Chiroli, Maurizio Benaglia, Franco Cozzi, Alessandra Puglisi, Rita Annunziata, Giuseppe Celentano
Org. Letters 2013.
DOI: 10.1021/ol401390z
Wednesday 3 July 2013
Monday 24 June 2013
Natural Products from St. John's Wort
Natural Products
from St. John's Wort
Enatiomers (−)-hyperione A and (−)-hyperione B can be
synthesised from a common precursor in ten stepsRead more
http://www.chemistryviews.org/details/ezine/1238795/Natural_Products_from_St__Johns_Wort.html
Monday 17 June 2013
Improved R&D Efficiency Through Speedier Method Development (1)
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Various
approaches are available for improving the efficiency of analytical...
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http://www.pharmaceutical-business-review.com/suppliers/shimadzu-analytical-instrumentation/whitepapers/improved-rd-efficiency-through-speedier-method-development-1
Friday 14 June 2013
Tuesday 11 June 2013
Bruce Roth Awarded 2013 Perkin Medal
Roth
Credit: Genentech
Roth
Credit: Genentech
Bruce
Roth Awarded 2013 Perkin Medal
Honors:
Chemist was the first to synthesize the cholesterol-lowering drug atorvastatin,
also known as LipitorThe Society of Chemical Industry (SCI) has selected Bruce D. Roth, vice president of discovery chemistry at Genentech, as the winner of the 2013 Perkin Medal. The annual award is recognized as the highest honor given for outstanding work in applied chemistry in the U.S.
http://cen.acs.org/articles/91/web/2013/06/Bruce-Roth-Awarded-2013-Perkin.html
A Molecule Of Many Colors-With rigid wings and a flexible core, a new compound can switch between two shapes and glow one of three colors.
Flexible And Fluorescent
A molecule combining rigid anthraceneimide wings and a flexible
cyclooctatetraene core switches between a flat and a bent V shape. The R groups
are either hydrogens or n-butyl groups.
Credit: J. Am. Chem. Soc.
Flexible And Fluorescent
A molecule combining rigid anthraceneimide wings and a flexible
cyclooctatetraene core switches between a flat and a bent V shape. The R groups
are either hydrogens or n-butyl groups.
Credit: J. Am. Chem. Soc.
A Molecule Of Many Colors
Organic Chemistry: With rigid wings and a flexible core, a new compound can switch between two shapes and glow one of three colors.
A new, flexible, multi-ring organic compound fluoresces red, green,
or blue depending on its environment (J. Am. Chem. Soc. 2013, DOI: 10.1021/ja404198h). The molecule’s combination of rigid wings
and a flexible center could serve as a general design strategy for molecular
sensors, the researchers say.
The molecule, developed by a team of researchers, including Shohei Saito, Stephan Irle, and
Shigehiro Yamaguchi of Nagoya University in Japan, has two rigid anthraceneimide
wings on opposite sides of a floppy cyclooctatetraene core
read all at
http://cen.acs.org/articles/91/web/2013/06/Molecule-Colors.html
read all at
http://cen.acs.org/articles/91/web/2013/06/Molecule-Colors.html
Monday 10 June 2013
ORGANIC CHEMISTRY REACTIONS, website by DR ANTHONY CRASTO
Thursday 6 June 2013
DRUG SYNTHESIS PORTALS ON NET-A COLLECTION
READ ALL AT
http://newdrugapprovals.wordpress.com/drug-synthesis/
DRUG SYNTHESIS PORTALS ON NET-A COLLECTION
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