Sulfonamides are well known motifs in medicinal chemistry, forming a large family of antibacterial agents as well as being found in numerous other drugs. The chemistry of this functional group, however, is less well documented. This review seeks to bring together the various applications and advantages of this motif in organic synthesis, which includes the sulfonamide as an activating group, protecting group, leaving group and as a molecular scaffold.
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Jonathan Wilden obtained his PhD from the University of Southampton in 2001 having worked on the total synthesis of the marine natural product pseudopterosin with Professor David Harrowven. He then moved to the University of Sussex, Brighton, UK where his interest in sulfonamide chemistry began, working with Professor Steve Caddick. In 2004 he was appointed lecturer at University College London where his research interests include the synthesis of medicinally important compounds and exploitation of the sulfonamide group in organic synthesis.
