The dual catalyst enables selective access to the required stereoisomer © Science/AAAS
Chemists from the Swiss Federal Institute of Technology, ETH Zurich, have teamed chiral catalysts in pairs to selectively drive a reaction towards desired stereoisomeric products with high selectivity. Each catalyst activates one reagent and controls its substituent arrangement as it bonds to the other to form two neighbouring chiral centres. ‘We have shown that it is possible to develop fully stereodivergent reaction processes,’ says Erick Carreira, who led the work. ‘We expect that additional reactions displaying full stereodivergency will be identified.’
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http://www.rsc.org/chemistryworld/2013/05/catalyst-duo-powerful-stereocontrol-diastereomer
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