Telling Solvents Apart the Easy Way

Telling Solvents Apart the Easy Way

Help could be soon on hand for the horrible moment of thinking "What solvent did I just add to that reaction?"
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 http://www.chemistryviews.org/details/ezine/6830971/Telling_Solvents_Apart_the_Easy_Way.html

Catalytic Nitration of Anilines

Catalytic Nitration of Anilines

A copper-catalyzed mild nitration of protected anilines
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 http://www.chemistryviews.org/details/ezine/6712381/Catalytic_Nitration_of_Anilines.html

Solid Approach to Product Extraction

An effective solid-extraction method to simplify the workup of organic reactions
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 http://www.chemistryviews.org/details/news/6835901/Solid_Approach_to_Product_Extraction.html

A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly

 A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly 
I.R. Baxendale, J. Deeley, C.M. Griffiths-Jones, S.V. Ley, S. Saaby and G. Tranmer, J. Chem. Soc., Chem. Commun. 2006, 2566-2568.
http://pubs.rsc.org/en/Content/ArticleLanding/2006/CC/b600382f#!divAbstract 


 

A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalysts, scavengers or catch and release agents; our route involves the combination of seven separate synthetic steps linked into one continuous sequence utilizing flow chemistry.

A Fully Automated Continuous Flow Synthesis of 4,5-Disbustituted Oxaxoles

A Fully Automated Continuous Flow Synthesis of 4,5-Disbustituted Oxaxoles 
M. Baumann, I.R. Baxendale, S.V. Ley, C.D. Smith and G.K. Tranmer, Org. Lett. 2006, 8, 5231-5234.
 http://pubs.acs.org/doi/abs/10.1021/ol061975c

 A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.

Versatile, High Quality and Scalable Continuous Flow Production of Metal-Organic Frameworks

The precursor solutions are pumped continuously, mixed via a static-mixer (T-piece) and 

enter the coiled reactor tubes at temperature (T). A backpressure regulator (BPR) situated

after the reactor coil is used to maintain a constant liquid pressure. 

The residence time can be varied by changing the length of the reactor or pumping rates.

Figure 1: Schematic representation showing the general flow reactor

 setup for the production of MOFs.

http://www.nature.com/srep/2014/140625/srep05443/full/srep05443.html#f1

Further deployment of Metal-Organic Frameworks in applied settings 
requires their ready preparation at scale. Expansion of typical batch
 processes can lead to unsuccessful or low quality synthesis for some 
systems. Here we report how continuous flow chemistry can be
 adapted as a versatile route to a range of MOFs, by emulating 
conditions of lab-scale batch synthesis. This delivers ready 
synthesis of three different MOFs, with surface areas that 
closely match theoretical maxima, with production rates 
of 60 g/h at extremely high space-time yields.

Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane 2, 3- Diacetal Tartrates

Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane 2, 3- Diacetal Tartrates 

C.F. Carter, I.R. Baxendale, M. O’Brien, J.B.J. Pavey, S.V. Ley, Org. Biomol. Chem. 2009, 7, 4594.

http://pubs.rsc.org/en/Content/ArticleLanding/2009/OB/b917289k#!divAbstract
http://www.rsc.org/suppdata/ob/b9/b917289k/b917289k.pdf

Catherine F. Carter,^a   Ian R. Baxendale,^a   Matthew O'Brien,^a  John B. J. Pavey^b and   Steven V. Ley*^a  

*

Corresponding authors

^a

Department of Chemistry, Innovative Technology Centre, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk

^b

AstraZeneca, Bakewell Road, Loughborough, Leics, UK

The syntheses of butane-2,3-diacetal protected tartrate derivatives are described using continuous flow processing techniques with in-line purification and I.R. analytical protocol
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