A Fully Automated Continuous Flow Synthesis of 4,5-Disbustituted Oxaxoles
M. Baumann, I.R. Baxendale, S.V. Ley, C.D. Smith and G.K. Tranmer, Org. Lett. 2006, 8, 5231-5234.
http://pubs.acs.org/doi/abs/10.1021/ol061975c
A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.
No comments:
Post a Comment