Iodine-mediated arylation of benzoxazoles with aldehydes - Green Chemistry (RSC Publishing)

Iodine-mediated arylation of benzoxazoles with aldehydes - Green Chemistry (RSC Publishing):

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Fullerenols: Fulfilling our Future Energy Needs

Carbon to catalyze low-carbon, hydrogen economy

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http://www.chemistryviews.org/details/ezine/5132011/Fullerenols_Fulfilling_our_Future_Energy_Needs.html

Synthesis of Tolvaptan

《Chinese Journal of Pharmaceuticals》 2011-02

Synthesis of Tolvaptan

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http://en.cnki.com.cn/Article_en/CJFDTotal-ZHOU201102007.htm

YANG Chuanwei~1,MU Shuai~2,LIU Ying~3,WANG Pingbao~3,LIU Dengke~(3*) 
(1.School of Pharmacy,Henan University,Kaifeng 475004;2.
School of Chemical Engineering and Technology,
 Tianjin University,Tianjin 300072;3.
Tianjin Institute of Pharmaceutical Research,Tianjin 300193)  

Tolvaptan,a selective nonpeptide arginine vasopressin V_2 receptor antagonist,was synthesized
 from 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine by acylation and reduction to give 1-(4-amino-2-methylbenzoyl) -7- chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine,which was subjected to acylation with 2-methylbenzoyl chloride and reduction with sodium borohydride with an overall yield of about 45%.

【Key Words】： tolvaptan arginine vasopressin V_2 receptor antagonist heart failure hyponatremia synthesis
【Fund】： 天津市科技计划项目(09ZCKFSH01300)
【CateGory Index】： R914

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	【Citations】

	Chinese Journal Full-text Database 2 Hits
	1 LI Fan1, HOU Xingpu2, LI Lin1, LU Tao1, DU Yumin1 (1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017; 2. Shijiazhuang  Pharma Group NBP Pharmaceutical Co., Ltd., Shijiazhuang 052160); Synthesis of Antiparkinsonian Agent Istradefylline[J];Chinese Journal of Pharmaceuticals;2010-04 2 YANG Miao~1,SHUAI Jun~2,LIU Mo~3,LIU Deng-ke~(3*),WANG Ping-bao~3 (1.Tianjin Medical University,Tianjin 300070;2.Tianjin University;Tianjin 300072;  3.Tianjin Institute of Pharmaceutical Research,Tianjin 300193); Synthesis of 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine[J]; Chinese Journal of Pharmaceuticals;2009-09

	【Co-citations】

	Chinese Journal Full-text Database 1 Hits
	1 XIONG Xiao-yi,CHEN An-qun,HE Yong-mei(Chongqing Unis Chemical Co.,Ltd.,Chongqing 402161,China);Analysis of Cyanoacetic Acid Content by HPLC[J];Guangzhou Chemical Industry;2010-12

Direct synthesis of hydrogen peroxide in water in a continuous trickle bed reactor optimized to maximize productivity

Hydrogen peroxide direct synthesis was studied in continuous mode over a 5% wt Pd/C commercial catalyst in a Trickle Bed Reactor. The target of the study was to maximize the hydrogen peroxide production. The catalyst was uniformly diluted in quartz sand at different concentrations to investigate their effects on the direct synthesis.
The amount of catalyst and the distribution of the catalyst along the bed were optimized to obtain the highest possible yield. The distribution of the catalyst along the bed gave the possibility to significantly improve the selectivity and production of hydrogen peroxide (up to 0.5% under selected conditions). Higher production rate and selectivity were found when the catalyst concentration was decreased along the bed from the top to the bottom as compared to the uniformly dispersed catalyst.
The H₂/Pd ratio was found to be an important parameter that has to be investigated in the hydrogen peroxide direct synthesis. The effect of a pretreatment of the catalyst with a solution of sodium bromide and phosphoric acid was studied; the results showed how a catalyst pretreatment can lead to a real green hydrogen peroxide synthesis in water. Some optimization guidelines are also provided.

Green Chem., 2013, 15,2502-2513
DOI: 10.1039/C3GC40811F, Paper

Pierdomenico Biasi,*^a   Juan García-Serna,*^b   Alice Bittante^a and  Tapio Salmi^a

*

Corresponding authors

^a

Department of Chemical Engineering, Åbo Akademi University, Turku/Åbo, Finland
E-mail: bpierdom@abo.fi ;
Fax: +358 2 215 4479 ;
Tel: +358 2 215 4555

^b

Department of Chemical Engineering and Environmental Technology, University of Valladolid, Valladolid, Spain
E-mail: jgserna@iq.uva.es

Hydrogen peroxide direct synthesis was studied in continuous mode over a 5% wt Pd/C commercial catalyst in a Trickle Bed Reactor.

Iodine-mediated arylation of benzoxazoles with aldehydes

A simple and efficient methodology for the arylation of benzoxazoles with aldehydes using iodine as the mediator has been developed. The reaction proceeded smoothly with a range of substrates to give the corresponding arylated products in moderate to good yields

Green Chem., 2013, 15,2365-2368
DOI: 10.1039/C3GC41027G, Communication

Yew Chin Teo,^a   Siti Nurhanna Riduan^a and   Yugen Zhang*^a

*

Corresponding authors

^a

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore
E-mail: ygzhang@ibn.a-star.edu.sg ;
Fax: (+65) 6478-9020

A simple and efficient methodology for the arylation of benzoxazoles with aldehydes using iodine as the mediator has been developed

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