Cucurbiturils , molecular container that can encapsulate drug molecules and increase the solubility of drugs

Giving drug dropouts a new lease of life
Researchers in the US have designed a molecular container that can encapsulate drug molecules and increase their solubility - in one case by almost 3000 times. The new container appears to have low toxicity and can be built from readily available reagents. The finding opens the possibility of re-testing drug candidates that failed because they were insufficiently soluble or improving existing low-solubility drugs.


D Ma et al, Nat. Chem., 2012, DOI: 10.1038/nchem.1326 

An Efficient Asymmetric Synthesis of Manzacidin C

"An Efficient Asymmetric Synthesis of Manzacidin C" Tran, K.; Lombardi, P. J.; Leighton, J. L.
by 


James L. Leighton


Org. Lett. 2008, 10, 3165-3167. [Link] 





http://pubs.acs.org/doi/abs/10.1021/ol8011869

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molecules reacting

Imidazole derivatives: A comprehensive survey of their recognition properties

Pedro Molina ,  Alberto Tárraga and Francisco Otón

Affiliation Information

1. Departamento de Química Orgánica; Universidad de Murcia; Campus de Espinardo, , Spain

Org. Biomol. Chem., 2012, 10, 1711-1724

DOI:10.1039/C2OB06808G

http://pubs.rsc.org/en/Content/ArticleLanding/2012/OB/C2OB06808G

Due to its amphoteric nature the imidazole ring can function as selective and effective anion and/or cation and even neutral organic molecules receptor system.

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BOMBYKOL REVIEW AND SYNTHESIS

Bombykol is a pheromone released by the female silkworm moth to attract mates. Discovered by Adolf Butenandt in 1959, it was the first pheromone to be characterized chemically. Minute quantities of this pheromone can be used per acre of land to confuse male insects about the location of their female partners, it can thus serve as a lure in traps to effectively remove insects without spraying crops with large amounts of chemicals. Butenandt named the substance after the moth's Latin name Bombyx mori.

SEE MY PRESENTATION AT

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molecules reacting

Collection of organic chemistry sites

https://sites.google.com/site/anthonycrastoorganicchemistry/sites---my-own-on-the-net   use this link to access all my sites

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ARTEMISININ, our last line of defence against malaria

ARTEMISININ, our last line of defence against malaria


http://www.slideshare.net/anthonycrasto64/anthony-melvin-crasto-presents-artemisinin-11174931



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molecules reacting

Direct enzymatic route for the preparation of novel enantiomerically enriched hydroxylated β-amino ester stereoisomers

poster on
http://www2.pharm.u-szeged.hu/gyki/Anyagok/poszter/2011/barcelona/schostein.pdf

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molecules reacting