DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 30 Yrs Exp. in the feld of Organic Chemistry. Serving chemists around the world. Helping them with websites on Chemistry.Millions of hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contributionn

Friday, 30 May 2014

Visible-light-induced photocatalytic formyloxylation reactions of 3-bromooxindoles with water and DMF: the scope and mechanism

Green Chem., 2014, Advance Article
DOI: 10.1039/C4GC00647J, Paper
You-Quan Zou, Wei Guo, Feng-Lei Liu, Liang-Qiu Lu, Jia-Rong Chen, Wen-Jing Xiao
A highly efficient visible light induced formyloxylation reaction of 3-bromooxindoles was disclosed. Results of labeling experiments indicated that H2O and DMF were incorporated into the terminal 3-formyloxyoxindoles.
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The formyloxylation reaction of 3-bromooxindoles with water and N,N-dimethylformamide (DMF) has been developed in the presence of the photoredox catalyst fac-Ir(ppy)3 under irradiation of visible light at ambient temperature. The reaction provides a straightforward approach to pharmaceutically and synthetically useful 3-formyloxyoxindoles in high yields. The mechanism of this transformation was investigated by fluorescence quenching experiments, “on–off” switching of the light source, labeling experiments, mass spectral analyses and in situ IR experiments.


ANTHONY MELVIN CRASTO
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DR ANTHONY MELVIN CRASTO Ph.D
amcrasto@gmail.com
MOBILE-+91 9323115463
GLENMARK SCIENTIST ,  INDIA
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Wednesday, 14 May 2014

Oxidation from Air: New Meerwein Arylation



Oxidation from Air: New Meerwein Arylation

New carbooxygenation-type version of the Meerwein arylation allows introduction of oxygen from air by using manganese dioxide
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Building Strong Carbon Acids from 1,1-Bis(triflyl)alkadienes










Strong carbon acids set to become a useful class of organocatalysts
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Revealing the Essentials for Effective β-Glucopyranoside Recognition



Revealing the Essentials for Effective β-Glucopyranoside Recognition








A step forward in the design of synthetic receptors for the recognition of carbohydrates
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Organocatalytic Route to α-Amino Acid Derivatives









Both enantiomers of substituted α-amino acid derivatives selectively synthesized
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Sunday, 11 May 2014

A highly efficient approach to vanillin starting from 4-cresol

Green Chem., 2014, 16,2807-2814
DOI: 10.1039/C4GC00003J, Paper
Jian-An Jiang, Cheng Chen, Ying Guo, Dao-Hua Liao, Xian-Dao Pan, Ya-Fei Ji
A highly efficient three-step approach to vanillin has been developed starting from 4-cresol.

A highly efficient approach to the famous flavor and fragrance compound vanillin has been developed starting from 4-cresol with the attention focused on improving the sustainability of all the reactions. The approach involves a three-step sequence of the quasi-quantitative selective clean oxybromination of 4-cresol, the high-yield selective aerobic oxidation of 2-bromo-4-cresol, and the quantitative methoxylation of 3-bromo-4-hydroxybenzaldehyde with the recovery of pure methanol. Herein, the pivotal oxidation and methoxylation reactions are logically investigated and developed into two concise methodologies. As a green alternative, the approach holds significant value for the sustainable manufacturing of vanillin.
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Saturday, 19 April 2014

Au catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO2/H2




Green Chem., 2014, Advance Article
DOI: 10.1039/C4GC00153B, Paper
Leiduan Hao, Yanfei Zhao, Bo Yu, Hongye Zhang, Huanjun Xu, Zhimin Liu
The gold-catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO2 in the presence of H2 was reported, and a series of benzimidazoles were obtained under relatively mild conditions.


The gold-catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO2 in the presence of
 H2 was reported, and a series of benzimidazoles were obtained under relatively mild conditions. 
Several supported Au catalysts including Au/TiO2, Au/Al2O3, Au/ZnO, Au/polyurea and Au/hydrotalcite
 were examined for the synthesis of benzimidazole from the reaction of 2-nitroaniline with CO2 and H2, 
among which Au/TiO2 displayed the best performance. The reaction mechanism was investigated, 
and it was found that the production of benzimidazole underwent the formation of o-phenylenediamine 
via the hydrogenation of 2-nitroaniline, followed by the cyclization of o-phenylenediamine with CO2 and H2. 
This work provides a CO2-involved route for the synthesis of benzimidazoles, 
which may widen the applications of CO2 in the chemical synthesis.

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