Christer B. Aakeröy, Safiyyah Forbes and John Desper
CrystEngComm, 2014, 16, 5870 DOI:10.1039/C4CE00206G
Systematic structure–property studies on a series of co-crystals of potential cancer drugs with aliphatic dicarboxylic acids were undertaken. This study reveals that systematic changes to the molecular nature of the co-crystallizing agent combined with control over the way individual building blocks are organized within the crystalline lattice makes it possible to establish predictable links between molecular structure and macroscopic physical properties, such as melting behaviour and aqueous solubility. However, it is not possible to find any notable correlation between physical properties and chemical compositions in the absence of structural consistency.
Paper
Altering physical properties of pharmaceutical co-crystals in a systematic manner
*Corresponding authors
aDepartment of Chemistry, Kansas State University, 213 CBC Building, Manhattan, USA
E-mail: aakeroy@ksu.edu;
Fax: +1 785 532 6666 ;
Tel: +1 785 532 6096
E-mail: aakeroy@ksu.edu;
Fax: +1 785 532 6666 ;
Tel: +1 785 532 6096
CrystEngComm, 2014,16, 5870-5877
DOI: 10.1039/C4CE00206G
