REVIVAL
This new reaction combines chiral secondary and tertiary boronic esters (left) with lithiated aryls to form intermediates that rearrange upon electrophile addition, yielding aryl-alkyl coupling products.
The revival of a nearly 50-year-old technique for forming carbon-carbon bonds may help ease the synthesis of aryl derivatives, such as drug candidates.
Varinder K. Aggarwal and coworkers at the University of Bristol, in England, have taken a venerable but neglected synthesis called Zweifel olefination and made it new again (Nat. Chem. 2014, DOI: 10.1038/nchem.1971).
C–C Coupling Repertoire Grows
Organic Synthesis: Reaction eases addition of chiral carbon centers to aryl groups
http://cen.acs.org/articles/92/i24/CC-Coupling-Repertoire-Grows.html
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BRAZIL WORLDCUP WEEK 2014
