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Showing posts with label bristol. Show all posts
Showing posts with label bristol. Show all posts

Monday 26 January 2015

Synthesis of Prostaglandin Analogues, Latanoprost and Bimatoprost, Using Organocatalysis via a Key Bicyclic Enal Intermediate

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Synthesis of Prostaglandin Analogues, Latanoprost and Bimatoprost, Using Organocatalysis via a Key Bicyclic Enal Intermediate

School of Chemistry, University of Bristol, Cantock’s Close, Bristol, BS8 1TS, U.K.
Org. Lett., Article ASAP
DOI: 10.1021/ol503520f
Publication Date (Web): January 12, 2015
Copyright © 2015 American Chemical Society

Two antiglaucoma drugs, bimatoprost and latanoprost, which are analogues of the prostaglandin, PGF, have been synthesized in just 7 and 8 steps, respectively. The syntheses employ an organocatalytic aldol reaction that converts succinaldehyde into a key bicyclic enal intermediate, which is primed for attachment of the required lower and upper side chains. By utilizing the crystalline lactone, the drug molecules were prepared in >99% ee.


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Professor Varinder Aggarwal

Professor Varinder Aggarwal 
BA, PhD(Cantab), FRS

Professor

Area of research

Asymmetric synthesis, methodology and applications.

Asymmetric synthesis, methodology and applications.

My research interests include; the development of new catalytic processes for asymmetric synthesis; the development of chiral carbenoids and their use and subsequent applications in catalysis and synthesis; the development of new methodology and its applications in synthesis; total synthesis of biologically important targets.

Research keywords

  • catalytic processes
  • asymmetric synthesis
  • reactive intermediates
  • synthesis
  • carbenes
  • carbenoids

Latest publications

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