2,3-Dihydrobenzofuran

• CAS Number 496-16-2
    
 
• Empirical Formula (Hill Notation) C₈H₈O
    
 
• Molecular Weight 120.15
•  Beilstein Registry Number 111928
    

http://www.rsc.org/suppdata/gc/c4/c4gc01822b/c4gc01822b1.pdfhttp://www.rsc.org/suppdata/gc/c4/c4gc01822b/c4gc01822b1.pdf


1H NMR

MASS

IR

UV

1H NMRPREDICT

13C NMR PREDICT

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Multistep Flow Synthesis of 5-Amino-2-aryl-2H-[1,2,3]-triazole-4- carbonitriles

Using the Uniqsis FlowSyn flow chemistry system researchers from the UCB Biopharma. Belgium have developed a flow synthesis of 2-substituted 1,2,3-triazoles that demonstrates improvements over the conventional batch route.

The route involves the diazotisation of anilines and condensation with malononitrile followed by the nucleophilic addition of ammonia or an alkylamine and finally a novel copper catalysed cyclisation. The intermediate azide was generated and consumed in situ which enabled safe scale up under the flow-through conditions employed.

 

J. Jacq, P. Pasau, Chem Eur. J., 2014, 20, (38), 12223.