DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 30 Yrs Exp. in the feld of Organic Chemistry. Serving chemists around the world. Helping them with websites on Chemistry.Millions of hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Saturday, 21 January 2017

Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Green Chem., 2017, Advance Article
DOI: 10.1039/C6GC03355E, Communication
Pei-Zhi Zhang, Jian-An Li, Ling Zhang, Adedamola Shoberu, Jian-Ping Zou, Wei Zhang
A method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely. The product was separated by crystallization and the byproducts were recovery by distillation


Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Pei-Zhi Zhang,a   Jian-An Li,a   Ling Zhang,a  Adedamola Shoberu,a   Jian-Ping Zou*a and  Wei Zhang*b  
Corresponding authors
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Soochow University, 199 Renai Street, Suzhou, China
 E-mail: jpzou@suda.edu.cn
Centre for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, USA
 E-mail: wei2.zhang@umb.edu
Green Chem., 2017, Advance Article

DOI: 10.1039/C6GC03355E

A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.


Colorless solid, mp 258−260 °C, 73% yield (191 mg).

1H NMR (400 MHz, DMSO-d6): δ 12.85 (s, 1H), 8.17 (d, J = 7.1 Hz, 2H), 7.68 (d, J = 6.6 Hz, 2H), 7.53 (dd, J = 14.3, 6.8 Hz, 6H), 2.10 (s, 3H).

13C NMR (101 MHz, CDCl3): δ 161.15, 152.97, 138.68, 132.26, 131.62, 129.11, 129.02, 128.86, 128.15, 127.45, 119.09, 12.65.

 HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H15N2O 263.1184, found 263.1194.



  1. Wow! this is Amazing! Do you know your hidden name meaning ? Click here to find your hidden name meaning

  2. If you are stuck with your management assignment then in this case you can opt for our Marketing Assignments. we provide the best assignment help online.We also provide Marketing Research Assignment for students across the globe. for more information contact us +16692714848


  3. Dash86 Agen Judi slot online terbesar dan terpercaya, Kini menyediakan Bonus Deposit New Member 25% Dengan maksimal bonus Rp.250.000 Diawal

    1. bonus new member 25%
    2. bonus harian 30%
    3. minimal deposit 10rb
    kunjungi webnya di https://gameuang.xyz
    contact person : https://direct.lc.chat/9818285/

  4. okhatrimaza
    OKhatrimaza is a paired website that offers the latest khatrimaza full Bollywood movies, Hollywood movies, South India Movies, Telugu Movies, and Tamil Movies to download for free.

  5. Hey! Nice post. Are you not getting appropriate Assignment Help in Ireland? Get high-quality help from experts in assignment writing with Ph.D. and master's degrees. Visit our website now to know more about our services.

  6. Get Assignment Helper from our experts as we promise to provide you 24/7 writing service at affordable prices from expert writers who have been qualified from renowned colleges worldwide. With our writing services, you do not have to think about the quality as our professionals have been in the industry for years, and they know what the guidelines are.

  7. Are you looking for assignment help? Get the best service in the UK from our experts at affordable prices. We offer online writing services that are customized according to the student's needs and expectations. We make sure to deliver authentic content within the shortest time period.


  8. Assignment Help Liverpool

    Hire only the best and number 1 Best Assignment Experts service providers to get high-quality assignments, tailor-made and plagiarism-free all academic Assignment Help Liverpool. Our service is always on time and promises an A+ grade. We have worked with Liverpool University since 2012 and know very well how to write and frame assignments as per their choice.

  9. I have just read this blog and I’ll surely come back for more posts, and also this article gives the light in which we can observe the reality of the topic. Thanks for this nice article! Now read this too... jamb result checker 

  10. The worst time has passed”However, it is true that there are more improvements than before...because of the rising numbers of people living with HIV in the state of Nevada. How could they stigmatize all of them? Therefore everything becomes a little easier and we start to share everything... We also started to invite and visit each other in a community. You know, it is six years since I started taking antiretroviral drugs...Yet whatever problems I face, the worst time has passedWhen I was evicted from the family home by my mother, my father rented a small room for me. But my mother and brothers believed that having HIV was my own fault – and that I deserved to be punished...I also considered myself unworthy and without hope... But I have a child and eventually I convinced myself to live for my child’s sake.
    My mother knew nothing [about HIV]. She didn’t understand anything. Do you know why? She didn’t have [the chance] to go out of the house and communicate with society. However, my father does interact with the community. I know his friends are mature and dignified africa america. So he has a better understanding than her.My father came call me on a sadfull day sitting on my couch about a friend of his from africa who introduce him to Dr Itua herbal cure in africa in which he advise we should purchase his herbal medicine to cure my hiv so we did and Dr Itua prescribed I should drink the herbal medicine for two weeks to cure although we were so curious about the whole thing ,I finished the herbal medicine like he advised then he talked to me to visit my nearest clinic for check up I did and now I'm totally cured from Hiv my father was my rock and I and my family are now happy together also Dr Itua has be helpful in my community ever since he cure my Hiv so why I'm leaving my story on here today is to reach out someone out here to hope on God and never give up no matter the situation you that you are facing especially through this pandemic seasons which has really taught us all on how we should be helpful to each other and cherish one another.Dr Itua cures the following diseases..... Herpes,Liver cancer,Throat cancerLeukemia.,Alzheimer's disease,Chronic Diarrhea,Copd,Parkinson,Als,Adrenocortical carcinoma Infectious mononucleosis.
    Intestinal cancer,Uterine cancer,Fibroid,Bladder cancer,Hiv,Esophageal cancer,Gallbladder cancer,Kidney cancer,Hpv,Lung cancer,Melanoma,Mesothelioma,Multiple myeloma,Oral cancer,Sinus cancer,Hepatitis A,B/C,Skin cancer,Soft tissue sarcoma,Spinal cancer,Stomach cancer,Vaginal cancer,Vulvar cancer,
    Testicular cancer,Thyroid Cancer.You can contact Dr Itua Herbal Center on E-Mail: drituaherbalcenter@gmail.com Or Whats-App Chat : +2348149277967

  11. blockfi wallet is a cryptocurrency wallet and lending app that enables investors to buy, sell, store, borrow, and earn interest on crypto assets. Moreover, BlockFi users can earn rewards paid in cryptocurrency using the BlockFi Rewards Credit Card.
    uphold wallet is ideal if you want one place where you can buy and trade a variety of assets. It offers quite a few cryptocurrencies, along with precious metals, national currencies, and U.S. equities.