Building Strong Carbon Acids from 1,1-Bis(triflyl)alkadienes

Strong carbon acids set to become a useful class of organocatalysts
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Revealing the Essentials for Effective β-Glucopyranoside Recognition

Revealing the Essentials for Effective β-Glucopyranoside Recognition

A step forward in the design of synthetic receptors for the recognition of carbohydrates
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Organocatalytic Route to α-Amino Acid Derivatives

Both enantiomers of substituted α-amino acid derivatives selectively synthesized
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A highly efficient approach to vanillin starting from 4-cresol

A highly efficient approach to vanillin starting from 4-cresol

Green Chem., 2014, 16,2807-2814
DOI: 10.1039/C4GC00003J, Paper

Jian-An Jiang, Cheng Chen, Ying Guo, Dao-Hua Liao, Xian-Dao Pan, Ya-Fei Ji
A highly efficient three-step approach to vanillin has been developed starting from 4-cresol.

A highly efficient approach to the famous flavor and fragrance compound vanillin has been developed starting from 4-cresol with the attention focused on improving the sustainability of all the reactions. The approach involves a three-step sequence of the quasi-quantitative selective clean oxybromination of 4-cresol, the high-yield selective aerobic oxidation of 2-bromo-4-cresol, and the quantitative methoxylation of 3-bromo-4-hydroxybenzaldehyde with the recovery of pure methanol. Herein, the pivotal oxidation and methoxylation reactions are logically investigated and developed into two concise methodologies. As a green alternative, the approach holds significant value for the sustainable manufacturing of vanillin.

Au catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO2/H2

Au catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO2/H2

http://pubs.rsc.org/en/Content/ArticleLanding/2014/GC/C4GC00153B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

Green Chem., 2014, Advance Article
DOI: 10.1039/C4GC00153B, Paper

Leiduan Hao, Yanfei Zhao, Bo Yu, Hongye Zhang, Huanjun Xu, Zhimin Liu
The gold-catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO₂ in the presence of H₂ was reported, and a series of benzimidazoles were obtained under relatively mild conditions.

The gold-catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO₂ in the presence of

 H₂ was reported, and a series of benzimidazoles were obtained under relatively mild conditions. 

Several supported Au catalysts including Au/TiO₂, Au/Al₂O₃, Au/ZnO, Au/polyurea and Au/hydrotalcite

 were examined for the synthesis of benzimidazole from the reaction of 2-nitroaniline with CO₂ and H₂, 

among which Au/TiO₂ displayed the best performance. The reaction mechanism was investigated, 

and it was found that the production of benzimidazole underwent the formation of o-phenylenediamine 

via the hydrogenation of 2-nitroaniline, followed by the cyclization of o-phenylenediamine with CO₂ and H₂. 

This work provides a CO₂-involved route for the synthesis of benzimidazoles, 

which may widen the applications of CO₂ in the chemical synthesis.

ORGANIC SPECTROSCOPY INTERNATIONAL: Ethyl 4-nitrobenzoate NMR

ORGANIC SPECTROSCOPY INTERNATIONAL: Ethyl 4-nitrobenzoate NMR:



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Natural sweeteners maple syrup, agave, and honey are complex mixtures with bioactive components that might confer health benefits

Pass the syrup! Maple syrup is a complex mixture of compounds, incuding bioactive components that might confer health benefits.
http://cen.acs.org/articles/92/i15/ACS-Meeting-News-Looking-Beyond.html

http://cen.acs.org/articles/92/i15/ACS-Meeting-News-Looking-Beyond.html

http://cen.acs.org/articles/92/i15/ACS-Meeting-News-Looking-Beyond.html

Maple syrup, agave, and honey are well-known for their roles as sweeteners. As such, their primary constituents are simple sugars such as sucrose and fructose. But scientists exploring the composition of these sweeteners are finding them to be surprisingly complicated.

These sweet mixtures contain many other classes of compounds, especially polyphenols, some of which may have bioactivity that imparts health benefits. Scientists hope to identify the beneficial compounds and eventually increase their concentration in sweeteners, so sweets can be more than just treats. Researchers described their latest findings in a symposium sponsored by the Division of Agricultural & Food Chemistry at the American Chemical Society national meeting held last month in Dallas.

Maple syrup is produced from sap of certain maple species, especially the sugar maple, Acer saccharum, which is native to eastern North America. Maple syrup is produced only in the U.S. and Canada, and about 80% of the world’s supply comes from Quebec.