carboxylic acids

Organic Chemistry Chapter 21 Klein from Sarah Greening

A molecular database for developing organic solar cells

A molecular database for developing organic solar cell

Harvard researchers have released a massive database of more than 2 million molecules that might be useful in the construction of solar cells that rely on organic compounds for construction of organic solar cells for the production of renewable energy. Developed as part of the Materials Genome Initiative launched by the White House’s Office of … more…

http://www.kurzweilai.net/a-molecular-database-for-developing-organic-solar-cells?utm_source=KurzweilAI+Daily+Newsletter&utm_campaign=4fc1bf53a4-UA-946742-1&utm_medium=email&utm_term=0_6de721fb33-4fc1bf53a4-282116853

Lab Reproduction of Marine Compound with Antibiotic Properties

 

Baringolin is a marine product with antibiotic properties. Image: IRB Barcelona
 

Barcelona, Spain (Scicasts) – Bacterial resistance to drugs leads pharmaceutical labs to be in constant search for new antibiotics to treat the same diseases. For the last thirty years, the sea bottom has yielded a wealth of substances with properties of interest to the pharmaceutical industry.
 
Isolated from a marine microorganism off the coast of Alicante by the company BioMar, baringolin shows promising antibiotic activity at a very low concentration. The Combinatorial Lab headed by Fernando Albericio at the Institute for Research in Biomedicine (IRB Barcelona), which collaborates with BioMar, has now synthesized this molecule and revealed its structure. Today's results open up the possibility to better understand how this substance works and to design derivatives to turn into a viable drug in the next 10 years. These findings are published in todays' online edition of the journal Angewandte Chemie.

read all at

http://scicasts.com/bioit/1858-drug-development/6186-lab-reproduction-of-marine-compound-with-antibiotic-properties

From left to right, this image shows researchers Mercedes Alvárez, Xavier Just-Baringo and Fernando Albericio from the IRB Barcelona.
(Photo Credit: IRB Barcelona)

Xavier Just, PhD student at IRB Barcelona, has reproduced the natural structure in the lab

 Reference article:
Total Synthesis and Stereochemical Assignment of Baringolin
Xavier Just-Baringo, Paolo Bruno, Lars K. Ottesen, Librada M. Cañedo, Fernando Albericio and Mercedes Álvarez.
Angewandte Chemie (2013) http://dx.doi.org/10.1002/ange.201302372 (German Edition) http://dx.doi.org/10.1002/anie.201302372 (International Edition)

Natural Products from St. John's Wort

Natural Products from St. John's Wort

Enatiomers (−)-hyperione A and (−)-hyperione B can be synthesised from a common precursor in ten steps
Read more


http://www.chemistryviews.org/details/ezine/1238795/Natural_Products_from_St__Johns_Wort.html

Cheap nickel catalysis offers alternative to expensive enzymatic resolution, Switching chirality in amino acids

Amino acids are converted to their opposite enantiomers by complexation with a nickel(II) salt and a chiral ligand Switching chirality in amino acids
	Cheap nickel catalysis offers alternative to expensive enzymatic resolution http://www.rsc.org/chemistryworld/2013/06/switching-chirality-amino-acids-nickel-catalysis

Improved R&D Efficiency Through Speedier Method Development (1)

Improved R&D Efficiency Through Speedier Method Development (1)

Various approaches are available for improving the efficiency of analytical...

http://www.pharmaceutical-business-review.com/suppliers/shimadzu-analytical-instrumentation/whitepapers/improved-rd-efficiency-through-speedier-method-development-1

Strategic Approaches to Process Optimization and Scale-up

 
http://drug-scaleup-and-manufacturing.webnode.com/news/strategic-approaches-to-process-optimization-and-scale-up/