tag:blogger.com,1999:blog-812731277886384402024-03-18T15:17:54.618+05:30ORGANIC CHEMISTRY INTERNATIONALORGANIC CHEMISTRY INTERNATIONAL............
BY DR ANTHONY MELVIN CRASTO, Helping millions with websites, millions of hits on google. 30 yrs exp in the field of Process developmentDRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.comBlogger299125tag:blogger.com,1999:blog-81273127788638440.post-16979167344846186092019-01-29T17:24:00.001+05:302019-01-29T17:24:10.036+05:30Photo-organocatalytic synthesis of acetals from aldehydes<div dir="ltr" style="text-align: left;" trbidi="on">
<div style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px;">
<img alt="Graphical abstract: Photo-organocatalytic synthesis of acetals from aldehydes" data-mce-src="https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C8GC03605E" src="https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C8GC03605E" style="height: auto; max-width: 100%;" title="Graphical abstract" /></div>
<h3 class="h--heading3" style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif;">
Abstract</h3>
<div class="capsule__column-wrapper" style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px;">
<div class="capsule__text">
A mild and green photo-organocatalytic protocol for the highly efficient acetalization of aldehydes has been developed. Utilizing thioxanthenone as the photocatalyst and inexpensive household lamps as the light source, a variety of aromatic and aliphatic aldehydes have been converted into acyclic and cyclic acetals in high yields. The reaction mechanism was extensively studied<br />
<div class="article__title">
<h2 class="capsule__title fixpadv--m">
Photo-organocatalytic synthesis of acetals from aldehydes</h2>
<div class="fixpadv--m crossmark-button visible">
</div>
</div>
<div class="article__authors">
<span class="article__author-link"><a data-mce-href="https://pubs.rsc.org/en/results?searchtext=Author%3ANikolaos%20F.%20Nikitas" href="https://pubs.rsc.org/en/results?searchtext=Author%3ANikolaos%20F.%20Nikitas">Nikolaos F. Nikitas</a>,<sup>a</sup> </span><span class="article__author-link"><a data-mce-href="https://pubs.rsc.org/en/results?searchtext=Author%3AIerasia%20Triandafillidi" href="https://pubs.rsc.org/en/results?searchtext=Author%3AIerasia%20Triandafillidi">Ierasia Triandafillidi</a><sup>a</sup> and </span><span class="article__author-link"><a data-mce-href="https://pubs.rsc.org/en/results?searchtext=Author%3AChristoforos%20G.%20Kokotos" href="https://pubs.rsc.org/en/results?searchtext=Author%3AChristoforos%20G.%20Kokotos">Christoforos G. Kokotos</a>*<sup>a</sup> </span></div>
<div class="drawer-control fixpadv--m open">
<a class="drawer__handle" data-mce-href="https://pubs.rsc.org/en/Content/ArticleLanding/2019/GC/C8GC03605E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#" href="https://pubs.rsc.org/en/Content/ArticleLanding/2019/GC/C8GC03605E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#"> Author affiliations</a><br />
<div class="drawer__content">
<div>
<div class="article__author-affiliation">
*Corresponding authors</div>
<div class="article__author-affiliation">
<sup>a</sup>Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece<br /><b>E-mail:</b><a data-mce-href="mailto:ckokotos@chem.uoa.gr" href="mailto:ckokotos@chem.uoa.gr" title="ckokotos@chem.uoa.gr">ckokotos@chem.uoa.gr</a></div>
<a data-mce-href="https://pubs.rsc.org/en/Content/ArticleLanding/2019/GC/C8GC03605E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract" href="https://pubs.rsc.org/en/Content/ArticleLanding/2019/GC/C8GC03605E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract">https://pubs.rsc.org/en/Content/ArticleLanding/2019/GC/C8GC03605E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract</a><br />
<a data-mce-href="http://www.allfordrugs.com/wp-content/uploads/2019/01/STR1.jpg" href="http://www.allfordrugs.com/wp-content/uploads/2019/01/STR1.jpg" rel="attachment wp-att-10995"><img alt="STR1" class="alignnone size-full wp-image-10995" data-mce-src="http://www.allfordrugs.com/wp-content/uploads/2019/01/STR1.jpg" height="164" src="http://www.allfordrugs.com/wp-content/uploads/2019/01/STR1.jpg" style="height: auto; max-width: 100%;" width="563" /></a></div>
(3,3-Dimethoxypropyl)benzene (2a)6<br />
Colorless oil; 95% yield; 1H NMR (200 MHz, CDCl3) δ: 7.33-7.18 (5H, m, ArH), 4.37 (1H, t, J = 5.8 Hz, OCH), 3.33 (6H, s, 2 x OCH3), 2.68 (2H, t, J = 7.6 Hz, CH2), 1.98- 1.87 (2H, m, CH2); 13C NMR (50 MHz, CDCl3) δ: 141.8, 128.4, 125.9, 103.7, 52.8, 34.0, 30.8; MS (ESI) m/z 181 [M+H]+ .<br />
6. Q. Zhou, T. Jia. X.-X. Li, L. Zhou, C.-J. Li, Y. S. Feng, Synth. Commun., 2018, 48, 1068.</div>
</div>
<a data-mce-href="http://www.rsc.org/suppdata/c8/gc/c8gc03605e/c8gc03605e1.pdf" href="http://www.rsc.org/suppdata/c8/gc/c8gc03605e/c8gc03605e1.pdf">./////////</a>///////</div>
</div>
</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com63tag:blogger.com,1999:blog-81273127788638440.post-44213268714257675962017-10-20T15:12:00.001+05:302017-10-20T15:12:20.617+05:302,3-dihydrobenzofuran<div dir="ltr" style="text-align: left;" trbidi="on">
<div class="separator" style="clear: both; text-align: center;">
<img alt="2,3-Dihydrobenzofuran 99%" src="http://www.sigmaaldrich.com/content/dam/sigma-aldrich/structure5/131/mfcd00005855.eps/_jcr_content/renditions/mfcd00005855-medium.png" /></div>
<h1 itemprop="name" style="background-color: #fdfdfd; color: #403c36; font-family: helvitica, arial, serif; font-size: 28px; font-stretch: normal; line-height: normal; margin: 0px; padding: 0px;">
2,3-<wbr></wbr>Dihydrobenzofuran</h1>
<ul class="clearfix" style="background-color: #fdfdfd; font-family: arial, helvetica, sans-serif; font-size: 1.1em; font-stretch: normal; line-height: 1.4em; list-style-position: outside; list-style-type: none; margin: 0px; padding: 0px; width: 645px;">
<li style="border-right: 1px dotted rgb(215, 215, 215); display: inline; font-size: 1em; height: 17px; list-style: none outside; margin: 0px 10px 4px 0px; padding-right: 6px; word-wrap: break-word; zoom: 1;"><div style="color: #6d6d6d; display: inline-block; font-family: arial, serif; font-size: 11px; font-weight: bold; line-height: 17px; padding-bottom: 5px;">
CAS Number <a href="http://www.sigmaaldrich.com/catalog/search?term=496-16-2&interface=CAS%20No.&N=0&mode=partialmax&lang=en&region=IN&focus=product" style="color: #1d5293; cursor: pointer; outline: 0px;">496-16-2</a></div>
</li>
<li style="border-right: 1px dotted rgb(215, 215, 215); display: inline; font-size: 1em; height: 17px; list-style: none outside; margin: 0px 10px 4px 0px; padding-right: 6px; word-wrap: break-word; zoom: 1;"><div style="color: #6d6d6d; display: inline-block; font-family: arial, serif; font-size: 11px; font-weight: bold; line-height: 17px; padding-bottom: 5px;">
Empirical Formula (Hill Notation) C<sub style="font-size: 10px; line-height: 14px;">8</sub>H<sub style="font-size: 10px; line-height: 14px;">8</sub>O</div>
</li>
<li style="border-right: 1px dotted rgb(215, 215, 215); display: inline; font-size: 1em; height: 17px; list-style: none outside; margin: 0px 10px 4px 0px; padding-right: 6px; word-wrap: break-word; zoom: 1;"><div style="color: #6d6d6d; display: inline-block; font-family: arial, serif; font-size: 11px; font-weight: bold; line-height: 17px; padding-bottom: 5px;">
Molecular Weight 120.15</div>
</li>
<li style="border-right: 1px dotted rgb(215, 215, 215); display: inline; font-size: 1em; height: 17px; list-style: none outside; margin: 0px 10px 4px 0px; padding-right: 6px; word-wrap: break-word; zoom: 1;"><div style="color: #6d6d6d; display: inline-block; font-family: arial, serif; font-size: 11px; font-weight: bold; line-height: 17px; padding-bottom: 5px;">
Beilstein Registry Number 111928</div>
</li>
</ul>
<div class="separator" style="clear: both; text-align: center;">
<br /></div>
<div class="separator" style="clear: both; text-align: center;">
<br /></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-1MxfHA37DfM/Wedb5_8xk1I/AAAAAAAAamc/d_vXzWET5YglmN18r83I8aSANNwf2ObeACLcBGAs/s1600/str6.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="484" data-original-width="678" height="456" src="https://2.bp.blogspot.com/-1MxfHA37DfM/Wedb5_8xk1I/AAAAAAAAamc/d_vXzWET5YglmN18r83I8aSANNwf2ObeACLcBGAs/s640/str6.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-V-vluCwTVZ4/WeddJAId8jI/AAAAAAAAamk/TSBlkpwMGOkxLCXd7REY5BHdR4XSd7KdACLcBGAs/s1600/str6.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="480" data-original-width="713" height="430" src="https://3.bp.blogspot.com/-V-vluCwTVZ4/WeddJAId8jI/AAAAAAAAamk/TSBlkpwMGOkxLCXd7REY5BHdR4XSd7KdACLcBGAs/s640/str6.JPG" width="640" /></a></div>
<br />
http://www.rsc.org/suppdata/gc/c4/c4gc01822b/c4gc01822b1.pdf<a href="http://www.rsc.org/suppdata/gc/c4/c4gc01822b/c4gc01822b1.pdf">http://www.rsc.org/suppdata/gc/c4/c4gc01822b/c4gc01822b1.pdf</a><br />
<br />
<br />
1H NMR<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-ErQTHkHR4rI/WenDpnlji_I/AAAAAAAAas0/LJnGn4LjjcQp6HG6F1JzP0gH26CGLHrVgCLcBGAs/s1600/STR7.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="571" data-original-width="965" height="378" src="https://4.bp.blogspot.com/-ErQTHkHR4rI/WenDpnlji_I/AAAAAAAAas0/LJnGn4LjjcQp6HG6F1JzP0gH26CGLHrVgCLcBGAs/s640/STR7.JPG" width="640" /></a></div>
<br />
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-twwYsk6ONyM/WenCFph6xbI/AAAAAAAAasc/ZlOD4mDBc9skcsanHPQQnAv43sK5AvGKACLcBGAs/s1600/STR7.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="297" data-original-width="760" height="250" src="https://3.bp.blogspot.com/-twwYsk6ONyM/WenCFph6xbI/AAAAAAAAasc/ZlOD4mDBc9skcsanHPQQnAv43sK5AvGKACLcBGAs/s640/STR7.JPG" width="640" /></a></div>
<br />
MASS<br />
<img alt="Image result for nmr 2,3-dihydrobenzofuran" src="http://webbook.nist.gov/cgi/inchi?Spec=C496162&Index=0&Type=Mass" /><br />
IR<br />
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-RZqMkZvDMHs/WenDGQtQ-YI/AAAAAAAAaso/H1LHrmx1iJEDYy7Y083VNCbN_JETFHF3wCLcBGAs/s1600/STR7.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="249" data-original-width="1320" height="120" src="https://3.bp.blogspot.com/-RZqMkZvDMHs/WenDGQtQ-YI/AAAAAAAAaso/H1LHrmx1iJEDYy7Y083VNCbN_JETFHF3wCLcBGAs/s640/STR7.JPG" width="640" /></a></div>
<div class="separator" style="clear: both; text-align: center;">
<br /></div>
<div class="separator" style="clear: both; text-align: center;">
UV</div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-jr0xcYJN7xc/WenDGupvVPI/AAAAAAAAask/Zy3ZbLNgLEAfvZ3mIACoShk00D42tqLMACLcBGAs/s1600/STR8.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="392" data-original-width="1286" height="194" src="https://1.bp.blogspot.com/-jr0xcYJN7xc/WenDGupvVPI/AAAAAAAAask/Zy3ZbLNgLEAfvZ3mIACoShk00D42tqLMACLcBGAs/s640/STR8.JPG" width="640" /></a></div>
<br />
<br />
<br />
1H NMRPREDICT<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-I9Y-IJ0nKhc/WenEFMqbSII/AAAAAAAAas4/M-7E_6qlzUU2igQSKaQASSyQCnuXNf41ACLcBGAs/s1600/STR7.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="144" data-original-width="267" height="345" src="https://1.bp.blogspot.com/-I9Y-IJ0nKhc/WenEFMqbSII/AAAAAAAAas4/M-7E_6qlzUU2igQSKaQASSyQCnuXNf41ACLcBGAs/s640/STR7.JPG" width="640" /></a></div>
<br />
13C NMR PREDICT<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-cZDW1V4kpig/WenEduON-vI/AAAAAAAAatA/ba0bItK4vKcd7nAJI1mawolvCBPLJwLpACLcBGAs/s1600/STR7.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="138" data-original-width="285" height="309" src="https://3.bp.blogspot.com/-cZDW1V4kpig/WenEduON-vI/AAAAAAAAatA/ba0bItK4vKcd7nAJI1mawolvCBPLJwLpACLcBGAs/s640/STR7.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-M3F2rvIcEH8/WenEd6ho6jI/AAAAAAAAatE/zWZXztCbAz84KzHtctQx3secLktJ1uz3gCLcBGAs/s1600/STR8.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="280" data-original-width="655" height="272" src="https://4.bp.blogspot.com/-M3F2rvIcEH8/WenEd6ho6jI/AAAAAAAAatE/zWZXztCbAz84KzHtctQx3secLktJ1uz3gCLcBGAs/s640/STR8.JPG" width="640" /></a></div>
<br />
<br />
//////</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com29tag:blogger.com,1999:blog-81273127788638440.post-49460391574474054652017-10-09T17:44:00.001+05:302017-10-09T17:44:57.222+05:30A green route for methanol carbonylation<div dir="ltr" style="text-align: left;" trbidi="on">
<br />
<div class="itemcontent" style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px;">
<div>
<img align="center" alt="" class="" data-mce-src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C7CY01621B" height="410" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C7CY01621B" style="height: auto; max-width: 100%;" width="901" /><br />
<h4 class="itemtitle">
<a data-mce-href="http://feeds.rsc.org/~r/rss/cy/~3/HwbXkalNjv8/C7CY01621B" href="http://feeds.rsc.org/~r/rss/cy/~3/HwbXkalNjv8/C7CY01621B">A green route for methanol carbonylation</a></h4>
</div>
<div>
<i><b>Catal. Sci. Technol.</b></i>, 2017, Advance Article<br /><b>DOI</b>: 10.1039/C7CY01621B, Paper</div>
<div>
Youming Ni, Lei Shi, Hongchao Liu, Wenna Zhang, Yong Liu, Wenliang Zhu, Zhongmin Liu<br />Halide-free and noble metal-free pyridine-modified H-mordenites exhibit high stability and selectivity in methanol carbonylation to acetic acid.</div>
<div>
<a data-mce-href="http://pubs.rsc.org/en/Content/ArticleLanding/2017/CY/C7CY01621B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fcy+%28RSC+-+Catalysis+Science+%26+Technology+latest+articles%29#!divAbstract" href="http://pubs.rsc.org/en/Content/ArticleLanding/2017/CY/C7CY01621B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fcy+%28RSC+-+Catalysis+Science+%26+Technology+latest+articles%29#!divAbstract">http://pubs.rsc.org/en/Content/ArticleLanding/2017/CY/C7CY01621B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fcy+%28RSC+-+Catalysis+Science+%26+Technology+latest+articles%29#!divAbstract</a></div>
<div>
<div class="article__title">
<h2 class="capsule__title fixpadv--m">
A green route for methanol carbonylation</h2>
</div>
<div class="article__authors">
<span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AYouming%20Ni" href="http://pubs.rsc.org/en/results?searchtext=Author%3AYouming%20Ni">Youming Ni</a>,<sup>a</sup><sup>b</sup> </span><span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3ALei%20Shi" href="http://pubs.rsc.org/en/results?searchtext=Author%3ALei%20Shi">Lei Shi</a>,<sup>a</sup><sup>b</sup> </span><span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AHongchao%20Liu" href="http://pubs.rsc.org/en/results?searchtext=Author%3AHongchao%20Liu">Hongchao Liu</a>,<sup>a</sup><sup>b</sup> </span><span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AWenna%20Zhang" href="http://pubs.rsc.org/en/results?searchtext=Author%3AWenna%20Zhang">Wenna Zhang</a>,<sup>a</sup><sup>b</sup><sup>c</sup> </span><span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AYong%20Liu" href="http://pubs.rsc.org/en/results?searchtext=Author%3AYong%20Liu">Yong Liu</a>,<sup>a</sup><sup>b</sup> </span><span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AWenliang%20Zhu" href="http://pubs.rsc.org/en/results?searchtext=Author%3AWenliang%20Zhu">Wenliang Zhu</a>*<sup>a</sup><sup>b</sup> and </span><span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AZhongmin%20Liu" href="http://pubs.rsc.org/en/results?searchtext=Author%3AZhongmin%20Liu">Zhongmin Liu</a>*<sup>a</sup><sup>b</sup> </span></div>
<div class="drawer-control fixpadv--m open">
<a class="drawer__handle" data-mce-href="http://pubs.rsc.org/en/Content/ArticleLanding/2017/CY/C7CY01621B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fcy+%28RSC+-+Catalysis+Science+%26+Technology+latest+articles%29#" href="http://pubs.rsc.org/en/Content/ArticleLanding/2017/CY/C7CY01621B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fcy+%28RSC+-+Catalysis+Science+%26+Technology+latest+articles%29#"> Author affiliations</a><br />
<div class="drawer__content">
<div class="article__author-affiliation">
*Corresponding authors</div>
<div class="article__author-affiliation">
<sup>a</sup>National Engineering Laboratory for Methanol to Olefins, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China<br /><b>E-mail:</b> <a data-mce-href="mailto:wlzhu@dicp.ac.cn" href="mailto:wlzhu@dicp.ac.cn" title="wlzhu@dicp.ac.cn">wlzhu@dicp.ac.cn</a>, <a data-mce-href="mailto:liuzm@dicp.ac.cn" href="mailto:liuzm@dicp.ac.cn" title="liuzm@dicp.ac.cn">liuzm@dicp.ac.cn</a></div>
<div class="article__author-affiliation">
<sup>b</sup>Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, PR China</div>
<div class="article__author-affiliation">
<sup>c</sup>University of Chinese Academy of Sciences, Beijing 100049, PR China</div>
</div>
</div>
<h3 class="h--heading3">
Abstract</h3>
<div class="capsule__column-wrapper">
<div class="capsule__text">
Acetic acid is one of the most important bulk commodity chemicals and is currently manufactured by methanol carbonylation reactions with rhodium or iridium organometallic complexes and halide-containing promoters named Monsanto or BP Cativa™ homogeneous processes, respectively. Developing a halide-free catalyst and a heterogeneous process for methanol carbonylation is of great importance and has recently attracted extensive research attention. Here, we report a green route for direct synthesis of acetic acid <em>via</em> vapor-phase carbonylation of methanol with a stable, selective, halide-free, and noble metal-free catalyst based on pyridine-modified H-mordenite zeolite. Methanol conversion and acetic acid selectivity can reach up to 100% and 95%, respectively. Only little deactivation is observed during the 145 hour reaction.</div>
</div>
</div>
</div>
<div style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px;">
</div>
<div style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px;">
////////////</div>
</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com17tag:blogger.com,1999:blog-81273127788638440.post-7109089508805839062017-09-17T09:55:00.000+05:302017-09-17T09:55:03.238+05:30 Endo-4,7-bis(hydroxymethyl)hexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione (endo-4,7- bis(hydroxymethyl)norcantharimide)<div dir="ltr" style="text-align: left;" trbidi="on">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-HsE8kwGto5M/Wb33oMJA6wI/AAAAAAAAaW8/M0_47_LxyLc_Qa7gItNK1vHVR9--7eWBgCLcBGAs/s1600/str4.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="557" data-original-width="872" height="408" src="https://2.bp.blogspot.com/-HsE8kwGto5M/Wb33oMJA6wI/AAAAAAAAaW8/M0_47_LxyLc_Qa7gItNK1vHVR9--7eWBgCLcBGAs/s640/str4.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-3nQI0sH4va0/Wb33oNos0zI/AAAAAAAAaW0/pr0uOVLfzkIAd57cpvMLXo1MPjU88XVOQCLcBGAs/s1600/str6.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="567" data-original-width="942" height="384" src="https://4.bp.blogspot.com/-3nQI0sH4va0/Wb33oNos0zI/AAAAAAAAaW0/pr0uOVLfzkIAd57cpvMLXo1MPjU88XVOQCLcBGAs/s640/str6.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-pzYCw0PRXqE/Wb336GG-YpI/AAAAAAAAaXE/LXkzpoY7sbAhLIZxDvlYNRwCdigM_P-JgCLcBGAs/s1600/str4.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="542" data-original-width="903" height="384" src="https://4.bp.blogspot.com/-pzYCw0PRXqE/Wb336GG-YpI/AAAAAAAAaXE/LXkzpoY7sbAhLIZxDvlYNRwCdigM_P-JgCLcBGAs/s640/str4.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-mA7ZuScy9S8/Wb335xga61I/AAAAAAAAaXA/tJLW4rJjGLM1T15U8I4863XrnNwtPFqPQCLcBGAs/s1600/str6.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="547" data-original-width="901" height="388" src="https://2.bp.blogspot.com/-mA7ZuScy9S8/Wb335xga61I/AAAAAAAAaXA/tJLW4rJjGLM1T15U8I4863XrnNwtPFqPQCLcBGAs/s640/str6.JPG" width="640" /></a></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-Kztj5Uhgiks/Wb33oHvT9UI/AAAAAAAAaW4/C8x3WFbr_NUDpBzDhPlP0BqI1HMXtho2QCLcBGAs/s1600/STR7.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="561" data-original-width="916" height="390" src="https://1.bp.blogspot.com/-Kztj5Uhgiks/Wb33oHvT9UI/AAAAAAAAaW4/C8x3WFbr_NUDpBzDhPlP0BqI1HMXtho2QCLcBGAs/s640/STR7.JPG" width="640" /></a></div>
<br />
<br />
Endo-4,7-bis(hydroxymethyl)hexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione (endo-4,7- bis(hydroxymethyl)norcantharimide), 4 (method A)<br />
<br />
Endo-4,7-bis(hydroxymethyl)norcantharimid-5-ene (120 mg, 0.53 mmol) was dissolved in water (3 mL), Pd/C 10% was added (15 mg) and reaction mixture was placed under hydrogen atmosphere for 8 h at 24 °C. Catalyst was filtered off and washed thoroughly with water (3 × 3 mL), filtrate was evaporated under reduced pressure. Target compound 4 was obtained as white solid, yield 87% (110 mg).<br />
<br />
1H NMR (D2O) = 3.76 (s, 4H), 3.46 (s, 2H), 1.61-1.72 (m, 4H);<br />
<br />
1H NMR (DMSO-d6) = 11.10 (s, 1H), 5.08 (s, 2H), 3.66 (s, 4H), 3.37 (s, 2H), 1.71 (m, 2H), 1.49 (m, 2H);<br />
<br />
13C NMR (D2O) = 179.0, 88.8, 60.7, 52.3, 27.0 ppm.<br />
<br />
m/z HRMS (ESI) Calcd. for C10H13NO5 [M+Na]: 250.0686. Found 250.0696.<br />
<br />
<div style="background-color: white; color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px;">
<h4 class="itemtitle" style="color: #d5000b; font-family: arial, tahoma, helvetica, freesans, sans-serif; font-size: 26px; font-stretch: normal; font-weight: normal; line-height: normal; margin: 0px; position: relative;">
<a data-mce-href="http://feeds.rsc.org/~r/rss/GC/~3/UhwMpS-2lRs/C7GC02211E" href="http://feeds.rsc.org/~r/rss/GC/~3/UhwMpS-2lRs/C7GC02211E" style="color: #b22223;">Efficient route for the construction of polycyclic systems from bioderived HMF</a> </h4>
</div>
<div style="background-color: white; color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px;">
<i><b>Green Chem.</b></i>, 2017, Advance Article<br />
<b>DOI</b>: 10.1039/C7GC02211E, Paper</div>
<div style="background-color: white; color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px;">
F. A. Kucherov, K. I. Galkin, E. G. Gordeev, V. P. Ananikov<br />
Efficient one-pot synthesis of tricyclic compounds from biobased 5-hydroxymethylfurfural (HMF) is described using a [4 + 2] cycloaddition reaction.</div>
<div style="background-color: white; color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px;">
<div class="article__title">
<h2 class="capsule__title fixpadv--m" style="border-bottom: 1px solid transparent; color: #616161; font-family: arial, tahoma, helvetica, freesans, sans-serif; font-size: 14px; font-stretch: normal; line-height: normal; margin: 0px; padding: 0.6em 0px 0.5em; position: relative;">
Efficient route for the construction of polycyclic systems from bioderived HMF</h2>
</div>
<div class="article__authors">
<span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AF.%20A.%20Kucherov" href="http://pubs.rsc.org/en/results?searchtext=Author%3AF.%20A.%20Kucherov" style="color: #b22223;">F. A. Kucherov</a>,<sup>a</sup> </span><span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AK.%20I.%20Galkin" href="http://pubs.rsc.org/en/results?searchtext=Author%3AK.%20I.%20Galkin" style="color: #b22223;">K. I. Galkin</a>,<sup>a</sup> </span><span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AE.%20G.%20Gordeev" href="http://pubs.rsc.org/en/results?searchtext=Author%3AE.%20G.%20Gordeev" style="color: #b22223;">E. G. Gordeev</a><sup>a</sup> and </span><span class="article__author-link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AV.%20P.%20Ananikov" href="http://pubs.rsc.org/en/results?searchtext=Author%3AV.%20P.%20Ananikov" style="color: #b22223;">V. P. Ananikov</a>*<sup>a</sup> </span></div>
<div class="drawer-control fixpadv--m open">
<a class="drawer__handle" data-mce-href="http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC02211E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#" href="http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC02211E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#" style="color: #b22223;"> Author affiliations</a><br />
<div class="drawer__content">
<div class="article__author-affiliation">
*Corresponding authors</div>
<div class="article__author-affiliation">
<sup>a</sup>Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky pr. 47, Moscow 119991, Russia<br />
<b>E-mail:</b> <a data-mce-href="mailto:val@ioc.ac.ru" href="mailto:val@ioc.ac.ru" style="color: #b22223;" title="val@ioc.ac.ru">val@ioc.ac.ru</a><br />
<b>Web:</b> http://AnanikovLab.ru</div>
</div>
</div>
</div>
<a data-mce-href="http://www.rsc.org/suppdata/c7/gc/c7gc02211e/c7gc02211e1.pdf" href="http://www.rsc.org/suppdata/c7/gc/c7gc02211e/c7gc02211e1.pdf" style="background-color: white; color: #b22223; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px;">//////</a><span style="background-color: white; color: #333333; font-family: "georgia" , "times new roman" , "bitstream charter" , "times" , serif; font-size: 16px;">////</span></div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com2tag:blogger.com,1999:blog-81273127788638440.post-60153700952863626912017-05-19T18:38:00.002+05:302017-05-19T18:38:51.325+05:30Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions<div dir="ltr" style="text-align: left;" trbidi="on">
<h4 class="itemtitle" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 18px; letter-spacing: -0.25px; margin: 0px; padding: 0px;">
</h4>
<h5 class="itemposttime" style="background-color: #dddddd; color: #666666; font-family: Helvetica, Arial, sans-serif; font-size: 14px; font-weight: normal; margin: 3px 0px 6px; padding: 0px;">
</h5>
<div class="itemcontent" name="decodeable" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 18.2px; overflow: hidden; width: 693px;">
<div>
<div style="margin-bottom: 1em; padding: 0px;">
<img align="center" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C7GC00657H" height="233" width="640" /></div>
</div>
<div>
<i><b>Green Chem.</b></i>, 2017, Advance Article<br />
<b>DOI</b>: 10.1039/C7GC00657H, Paper</div>
<div>
Nelly Ntumba Tshibalonza, Jean-Christophe M. Monbaliu<br />
Highly selective flash deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions.</div>
</div>
<h4 class="itemtitle" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 18px; letter-spacing: -0.25px; margin: 0px; padding: 0px;">
<a href="http://feeds.rsc.org/~r/rss/GC/~3/1fYYCt5Inng/C7GC00657H" style="color: #000099; text-decoration-line: none;">Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions</a></h4>
<br />
<a href="https://www.blogger.com/goog_619280594"><br /></a>
<a href="https://www.blogger.com/goog_619280594"><img alt="Image result for Nelly Ntumba Tshibalonza" height="479" src="http://www.cata.ulg.ac.be/photos/Nelly_Tshibalonza.jpg" width="640" /></a><br />
<a href="https://www.blogger.com/goog_619280594"><br /></a>
<br />
<br />
<h2 style="background-color: white; font-family: Verdana, Arial, Helvetica, sans-serif; font-variant-caps: small-caps; font-variant-numeric: normal; line-height: 1.5em; margin: 0px; padding: 10px 0px;">
Ms. Nelly Tshibalonza Ntumba</h2>
<a class="highslide" href="http://www.cata.ulg.ac.be/photos/Nelly_Tshibalonza.jpg" id="thumb6" style="background-color: white; color: #0f2b8f; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 14px; margin: 0px; outline: none; padding: 0px; text-decoration-line: none;"><img alt="Nelly Tshibalonza" class="alignleft" height="180" src="http://www.cata.ulg.ac.be/photos/Nelly_Tshibalonza_small.jpg" style="border: 2px solid silver; cursor: url("graphics/zoomin.cur"), pointer !important; display: inline; float: left; margin: 0px 8px 0px 0px; padding: 0px;" title="Click to enlarge" width="150" /></a><br />
<div style="background-color: white; color: #333333; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 14px; margin-bottom: 18px; padding: 0px; text-align: justify;">
Nelly Tshibalonza was born in 1983 in Kinshasa, Congo. She received her diploma degree in Chemistry in 2006 from the University of Kinshasa. She is currently a fellow of the Belgian Technical Cooperation and is preparing a Ph.D. thesis on the development of catalytic methods to enhance the value of renewable raw materials.</div>
<div style="background-color: white; color: #333333; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 14px; margin-bottom: 18px; padding: 0px; text-align: justify;">
E-mail: <a href="mailto:nel.tshibalonza@student.ulg.ac.be" style="color: #0f2b8f; margin: 0px; padding: 0px; text-decoration-line: none;">nel.tshibalonza@student.ulg.ac.be</a><br style="margin: 0px; padding: 0px;" />Telephone: +32 (0)4 366-3493</div>
<br />
<br />
<br />
<br />
<a href="http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC00657H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract">http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC00657H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract</a><br />
<br />
<br />
<div class="article__title" style="background-color: white; color: rgba(0, 0, 0, 0.79); display: table; font-family: museo_sans300, museo-sans; font-size: 16px; letter-spacing: -0.32px; width: 617px;">
<h2 class="capsule__title fixpadv--m" style="-webkit-margin-after: 0px; -webkit-margin-before: 0px; color: rgba(0, 0, 0, 0.75); display: table-cell; font-family: MuseoSlab700Regular, museo-slab; font-size: 24px; letter-spacing: -0.02em; line-height: 28px; margin: 0px; overflow: hidden; padding-bottom: 12px; padding-top: 12px;">
Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions</h2>
<div class="fixpadv--m crossmark-button visible" style="display: table-cell; height: 35px; padding-bottom: 12px; padding-left: 20px; padding-top: 12px; vertical-align: top; visibility: visible; width: 150px;">
</div>
</div>
<div aria-label="List of authors" class="article__authors" style="background-color: white; color: #505759; font-family: museo_sans300, museo-sans; font-size: 16px; letter-spacing: -0.32px; margin: 8px 0px; padding-bottom: 8px; padding-top: 0px;">
<span class="article__author-link" style="font-size: 14px; line-height: 20px;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3ANelly%20Ntumba%20Tshibalonza" style="color: #2d7ea9;">Nelly Ntumba Tshibalonza</a><span style="position: relative; top: -0.4em; vertical-align: baseline;">a</span> and </span><span class="article__author-link" style="font-size: 14px; line-height: 20px;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AJean-Christophe%20M.%20Monbaliu" style="color: #2d7ea9;">Jean-Christophe M. Monbaliu</a><span style="font-size: 16px;">*</span><span style="position: relative; top: -0.4em; vertical-align: baseline;">a</span> </span></div>
<div class="drawer-control fixpadv--m open" style="background-color: white; color: rgba(0, 0, 0, 0.79); font-family: museo_sans300, museo-sans; font-size: 16px; letter-spacing: -0.32px; padding-bottom: 12px; padding-top: 12px; position: relative;">
<a class="drawer__handle" href="http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC00657H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#" style="color: #2d7ea9; display: block; font-size: 14px; line-height: 16px; text-decoration-line: none;"><span class="drawer__icon" style="background-image: url("../CDN/icons-24/minus-o.png"); background-position: center center; background-repeat: no-repeat; background-size: contain; display: inline-block; height: 16px; margin-right: 4px; transform: rotate(180deg); transition: all 0.4s ease-in-out; vertical-align: middle; width: 16px;"></span> Author affiliations</a><div class="drawer__content" style="margin-top: 0px;">
<div class="article__author-affiliation" style="display: table; font-size: 15px;">
<span style="display: table-cell; padding-left: 4px; width: 7px;">*</span><span style="display: table-cell; padding-left: 12px;">Corresponding authors</span></div>
<div class="article__author-affiliation" style="display: table; font-size: 15px;">
<span style="display: table-cell; padding-left: 4px; width: 7px;"><span style="position: relative; top: -0.4em; vertical-align: baseline;">a</span></span><span style="display: table-cell; padding-left: 12px;">Center for Integrated Technology and Organic Synthesis, Department of Chemistry, University of Liège, B-4000 Liège (Sart Tilman), Belgium<br /><b>E-mail:</b> <a href="mailto:jc.monbaliu@ulg.ac.be" style="color: #9d3d99;" title="jc.monbaliu@ulg.ac.be">jc.monbaliu@ulg.ac.be</a></span></div>
</div>
</div>
<h3 class="h--heading3" style="-webkit-margin-after: 24px; -webkit-margin-before: 32px; background-color: white; color: rgba(0, 0, 0, 0.9); font-family: museo_sans_500regular, museo-sans; font-size: 20px; font-weight: 500; letter-spacing: -0.02em; line-height: 24px; margin-bottom: 24px; margin-top: 32px;">
Abstract</h3>
<div class="capsule__column-wrapper" style="background-color: white; color: rgba(0, 0, 0, 0.79); font-family: museo_sans300, museo-sans; font-size: 16px; letter-spacing: -0.32px;">
<div class="capsule__text">
<div xmlns="http://www.rsc.org/schema/rscart38">
The deoxydehydration (DODH) of glycerol towards allyl alcohol was revisited under continuous-flow conditions combining a microfluidic reactor setup and a unique reactive dynamic feed solution approach. Short reaction times, high yield and excellent selectivity were achieved at high temperature and moderate pressure in the presence of formic acid, triethyl orthoformate, or a combination of both. Triethyl orthoformate appeared as a superior reagent for the DODH of glycerol, with shorter reaction times, lower reaction temperatures and more robust conditions. In-line IR spectroscopy and computations provided different perspectives on the unique reactivity of glycerol <em>O</em>,<em>O</em>,<em>O</em>-orthoesters.</div>
</div>
<div class="capsule__article-image fixpadv--s" style="margin-left: auto; margin-right: auto; max-height: 378px; max-width: 378px; padding-bottom: 8px; padding-top: 8px; text-align: center;">
<img alt="Graphical abstract: Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions" src="http://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C7GC00657H" style="border: none; margin-left: auto; margin-right: auto; max-height: 378px; max-width: 100%;" title="Graphical abstract" /></div>
</div>
<br />
<img alt="Image result for Jean-Christophe M. Monbaliu" height="568" src="http://www.citos.ulg.ac.be/images/JCM_picture.jpg" width="640" /><br />
<br />
<img alt="photo_JC_Monbaliu" height="128px" src="http://www.citos.ulg.ac.be/images/JCM_picture.jpg" style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;" width="144px" /><br style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;" /><span style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;">JC M. Monbaliu, PhD.</span><br style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;" /><span style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;">Lecturer</span><br style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;" /><span style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;">Department of Chemistry</span><a href="mailto:jc.monbaliu@ulg.ac.be" style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;">jc.monbaliu@ulg.ac.be</a><br style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;" /><span style="background-color: #ff8539; font-family: calibri, arial, sans-serif; font-size: 16px; text-align: -webkit-center;">t +32 (0) 4 366 35 10</span><br />
<br />
<a href="http://pubs.rsc.org/en/results?searchtext=Author%3AJean-Christophe%20M.%20Monbaliu" style="background-color: white; color: #2d7ea9; font-family: museo_sans300, museo-sans; font-size: 14px; letter-spacing: -0.32px;">Jean-Christophe M. Monbaliu</a><br />
<br />
///////////</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com4tag:blogger.com,1999:blog-81273127788638440.post-29461140276290620972017-02-25T16:45:00.000+05:302017-02-25T16:45:28.474+05:302-Methoxy-4-propylphenol<div dir="ltr" style="text-align: left;" trbidi="on">
<div style="color: #222222; font-family: "Open Sans", Tahoma, Verdana, Segoe, sans-serif; font-size: 16px; padding: 0px 0px 1em;">
<img data-mce-src="http://drugapprovalsint.com/wp-content/uploads/2017/02/STR1-48.jpg" src="http://drugapprovalsint.com/wp-content/uploads/2017/02/STR1-48.jpg" style="height: auto; margin-bottom: 10px; margin-top: 8px; max-width: 100%;" /> <img data-mce-src="http://drugapprovalsint.com/wp-content/uploads/2017/02/STR2-25.jpg" src="http://drugapprovalsint.com/wp-content/uploads/2017/02/STR2-25.jpg" style="height: auto; margin-bottom: 10px; margin-top: 8px; max-width: 100%;" /></div>
<div style="color: #222222; font-family: "Open Sans", Tahoma, Verdana, Segoe, sans-serif; font-size: 16px; padding: 0px 0px 1em;">
2-Methoxy-4-propylphenol</div>
<div style="color: #222222; font-family: "Open Sans", Tahoma, Verdana, Segoe, sans-serif; font-size: 16px; padding: 0px 0px 1em;">
2-Methoxy-4-propylphenol<br />1H NMR (400 Mhz, CDCl3) δ (ppm): 6.83 (1H,d, J = 7.8 Hz), 6.68 (2H, d, J = 7.4 Hz), 5.47 (1H, s), 3.79 (3H, s), 2.52 (2H, t, J =7.6 Hz), 1.61 (2H, sext, J = 7.5 Hz) 0.94 (3H, t, J = 7.3 Hz).</div>
<div style="color: #222222; font-family: "Open Sans", Tahoma, Verdana, Segoe, sans-serif; font-size: 16px; padding: 0px 0px 1em;">
13C NMR (100 MHz, CDCl3) δ (ppm) 146.4, 143.6,134.7, 121.0, 114.2, 111.1, 55.9, 37.8, 24.9, 13.8.</div>
<div style="color: #222222; font-family: "Open Sans", Tahoma, Verdana, Segoe, sans-serif; font-size: 16px; padding: 0px 0px 1em;">
HRMS (ESI-TOF) m/z: [M + H]+ calculated for C10H15O2:167.1067; found: 167.1064.</div>
<div style="color: #222222; font-family: "Open Sans", Tahoma, Verdana, Segoe, sans-serif; font-size: 16px; padding: 0px 0px 1em;">
<strong>DOI:</strong> 10.1021/acs.oprd.6b00441</div>
<div style="color: #222222; font-family: "Open Sans", Tahoma, Verdana, Segoe, sans-serif; font-size: 16px; padding: 0px;">
<a data-mce-href="http://pubs.acs.org/doi/full/10.1021/acs.oprd.6b00441" href="http://pubs.acs.org/doi/full/10.1021/acs.oprd.6b00441" style="color: #222222;">//////</a>///</div>
</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com1tag:blogger.com,1999:blog-81273127788638440.post-6892471064249403012017-01-21T08:59:00.000+05:302017-01-21T09:01:32.977+05:30 Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide<div dir="ltr" style="text-align: left;" trbidi="on">
<img align="center" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6GC03355E" height="220" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 14px;" width="640" /><br />
<br />
<br />
<br />
<br />
<h4 class="itemtitle" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 18px; letter-spacing: -0.25px; margin: 0px; padding: 0px;">
</h4>
<h4 class="itemtitle" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 18px; letter-spacing: -0.25px; margin: 0px; padding: 0px;">
</h4>
<h4 class="itemtitle" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 18px; letter-spacing: -0.25px; margin: 0px; padding: 0px;">
</h4>
<h4 class="itemtitle" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 18px; letter-spacing: -0.25px; margin: 0px; padding: 0px;">
<a href="http://feeds.rsc.org/~r/rss/GC/~3/pXrYQTgAcAU/C6GC03355E" style="color: #000099;">Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide</a></h4>
<h5 class="itemposttime" style="background-color: #dddddd; color: #666666; font-family: Helvetica, Arial, sans-serif; font-size: 14px; font-weight: normal; margin: 3px 0px 6px; padding: 0px;">
</h5>
<div class="itemcontent" name="decodeable" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 18.2px; overflow: hidden; width: 693px;">
<div>
<div style="margin-bottom: 1em; padding: 0px;">
<br /></div>
</div>
<div>
<i><b>Green Chem.</b></i>, 2017, Advance Article<br />
<b>DOI</b>: 10.1039/C6GC03355E, Communication</div>
<div>
Pei-Zhi Zhang, Jian-An Li, Ling Zhang, Adedamola Shoberu, Jian-Ping Zou, Wei Zhang<br />
A method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely. The product was separated by crystallization and the byproducts were recovery by distillation</div>
</div>
<br />
<a href="http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C6GC03355E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#">http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C6GC03355E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#</a>!divAbstract<br />
<br />
<div class="article_chemsoc_txt_s13" style="background-color: white; color: #003c73; float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px; margin-bottom: 5px; padding-left: 10px; padding-right: 10px; width: 520px;">
<h2 class="alpH1" style="color: #223335; float: left; font-family: MuseoSlab700Regular, Arial; font-size: 21px; font-weight: normal; letter-spacing: 0em; line-height: 21px; margin: 16px 0px; padding: 0px;">
Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide</h2>
</div>
<div class="peptide_wrap_s10_left" style="background-color: white; float: left; font-family: arial; font-size: 12px; height: auto; padding-left: 10px; padding-top: 5px; width: 320px;">
<div class="peptide_middle" style="float: left; font-family: Arial, Helvetica, sans-serif; line-height: 20px; width: 320px;">
<div>
<span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3APei-Zhi%20Zhang" style="color: black; position: relative;">Pei-Zhi Zhang</a>,<sup>a</sup> </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AJian-An%20Li" style="color: black; position: relative;">Jian-An Li</a>,<sup>a</sup> </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3ALing%20Zhang" style="color: black; position: relative;">Ling Zhang</a>,<sup>a</sup> </span><span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AAdedamola%20Shoberu" style="color: black; position: relative;">Adedamola Shoberu</a>,<sup>a</sup> </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AJian-Ping%20Zou" style="color: black; position: relative;">Jian-Ping Zou</a><span style="font-size: 16px;">*</span><sup>a</sup> and </span><span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AWei%20Zhang" style="color: black; position: relative;">Wei Zhang</a><span style="font-size: 16px;">*</span><sup>b</sup> </span></div>
<div class="show_affiliation_section" id="aff_info" style="background-color: #f6f6f7; float: left; margin-bottom: 5px; padding: 0px 3px 10px 5px; width: 320px;">
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
*</div>
<div style="padding-left: 10px;">
Corresponding authors</div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">a</sup></div>
<div style="padding-left: 10px;">
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Soochow University, 199 Renai Street, Suzhou, China<br />
<b> E-mail: </b><a href="mailto:jpzou@suda.edu.cn" style="color: #014682; position: relative; text-decoration: none;" title="jpzou@suda.edu.cn">jpzou@suda.edu.cn</a></div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">b</sup></div>
<div style="padding-left: 10px;">
Centre for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, USA<br />
<b> E-mail: </b><a href="mailto:wei2.zhang@umb.edu" style="color: #014682; position: relative; text-decoration: none;" title="wei2.zhang@umb.edu">wei2.zhang@umb.edu</a></div>
</div>
</div>
<div class="red_txt_s4" style="float: left; line-height: 18px; padding: 8px 0px 4px; width: 320px;">
<i><strong>Green Chem.</strong></i>, 2017, Advance Article</div>
<br />
<span class="DOILink" style="float: left; padding: 0px; width: 505px;"><strong>DOI: </strong>10.1039/C6GC03355E</span><br />
<div>
<br /></div>
</div>
</div>
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<span style="background-color: white; color: #222222; font-family: "arial"; font-size: 12px;">A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.</span><br />
<br />
<br />
2,6-diphenyl-5-methylpyrimidinone<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-vccbh-HrCJI/WILVo91kJcI/AAAAAAAAYM0/zEQvzVpOk4YJyeoYqag5O3a8GLRlVtCiQCLcB/s1600/STR1.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="232" src="https://2.bp.blogspot.com/-vccbh-HrCJI/WILVo91kJcI/AAAAAAAAYM0/zEQvzVpOk4YJyeoYqag5O3a8GLRlVtCiQCLcB/s640/STR1.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-90ne-E-2cN4/WILV3K7PIhI/AAAAAAAAYM8/kIa-_Et3d4EJsY5ZtbVu0oabm0lmCCZswCLcB/s1600/STR2.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="238" src="https://3.bp.blogspot.com/-90ne-E-2cN4/WILV3K7PIhI/AAAAAAAAYM8/kIa-_Et3d4EJsY5ZtbVu0oabm0lmCCZswCLcB/s640/STR2.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-hNDeBSRbVlI/WILV2wXSQNI/AAAAAAAAYM4/1ap_axYCSV03QhvWcPyxU-iOvitPND1DACLcB/s1600/str3.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="506" src="https://1.bp.blogspot.com/-hNDeBSRbVlI/WILV2wXSQNI/AAAAAAAAYM4/1ap_axYCSV03QhvWcPyxU-iOvitPND1DACLcB/s640/str3.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-MgATYklxGO0/WILV3Ib6v7I/AAAAAAAAYNA/rD3GtEwiVLQ2km95xDf_wTPNawKGVqurwCLcB/s1600/str4.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="444" src="https://4.bp.blogspot.com/-MgATYklxGO0/WILV3Ib6v7I/AAAAAAAAYNA/rD3GtEwiVLQ2km95xDf_wTPNawKGVqurwCLcB/s640/str4.JPG" width="640" /></a></div>
<br />
<br />
<br />
Colorless solid, mp 258−260 °C, 73% yield (191 mg).<br />
<br />
1H NMR (400 MHz, DMSO-d6): δ 12.85 (s, 1H), 8.17 (d, J =
7.1 Hz, 2H), 7.68 (d, J = 6.6 Hz, 2H), 7.53 (dd, J = 14.3, 6.8 Hz, 6H), 2.10 (s, 3H).<br />
<br />
13C NMR (101 MHz, CDCl3): δ
161.15, 152.97, 138.68, 132.26, 131.62, 129.11, 129.02, 128.86, 128.15, 127.45, 119.09, 12.65.<br />
<br />
HRMS (ESI-TOF)
m/z: (M+H)+ Calcd for C17H15N2O 263.1184, found 263.1194.<br />
<br />
<br />
<br />
<br />
<br />
<a href="http://www.rsc.org/suppdata/c6/gc/c6gc03355e/c6gc03355e1.pdf">////////</a>///</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com7tag:blogger.com,1999:blog-81273127788638440.post-69723369207911447492016-12-07T18:23:00.000+05:302016-12-07T18:23:51.856+05:30Organic Chemistry International Blog selected by Feedspot as one of the Top 50 Chemistry Blogs on the web. <div dir="ltr" style="text-align: left;" trbidi="on">
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-r3pXpDOxgP8/WEgFSIgmsyI/AAAAAAAAXWg/RYc98-Z4-V0gDaK9U92MnILQhdSFROKUQCLcB/s1600/TOP%2B50.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://2.bp.blogspot.com/-r3pXpDOxgP8/WEgFSIgmsyI/AAAAAAAAXWg/RYc98-Z4-V0gDaK9U92MnILQhdSFROKUQCLcB/s400/TOP%2B50.png" width="400" /></a></div>
<br />
<br />
<br />
<span style="background-color: white; color: #1d2129; font-family: Helvetica, Arial, sans-serif; font-size: 14px;">My blog Organic Chemistry International was selected by Feedspot as one of the Top 50 Chemistry Blogs on the web. </span><br />
<span style="background-color: white; color: #1d2129; font-family: Helvetica, Arial, sans-serif; font-size: 14px;">link is..........</span><a href="http://organicchemistrysite.blogspot.in/" rel="nofollow" style="background-color: white; color: #365899; cursor: pointer; font-family: Helvetica, Arial, sans-serif; font-size: 14px; text-decoration: none;" target="_blank">http://organicchemistrysite.blogspot.in/</a><span style="background-color: white; color: #1d2129; font-family: Helvetica, Arial, sans-serif; font-size: 14px;"> </span><br />
<span style="background-color: white; color: #1d2129; font-family: Helvetica, Arial, sans-serif; font-size: 14px;"><br /></span>
<span style="background-color: white; color: #1d2129; font-family: Helvetica, Arial, sans-serif; font-size: 14px;">FEEDSPOT</span><a href="http://blog.feedspot.com/chemistry_websites/" rel="nofollow" style="background-color: white; color: #365899; cursor: pointer; font-family: Helvetica, Arial, sans-serif; font-size: 14px; text-decoration: none;" target="_blank">http://blog.feedspot.com/chemistry_websites/</a><br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-3Gfz8_JkwT0/WEgFfm8DmyI/AAAAAAAAXWo/AaJkpxjYHeA_hfJYYIzVxdZnjKU2b4A6gCLcB/s1600/OCI.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="266" src="https://4.bp.blogspot.com/-3Gfz8_JkwT0/WEgFfm8DmyI/AAAAAAAAXWo/AaJkpxjYHeA_hfJYYIzVxdZnjKU2b4A6gCLcB/s640/OCI.JPG" width="640" /></a></div>
<br />
<br />
<br />
<br />
/////<span style="background-color: white; color: #1d2129; font-family: Helvetica, Arial, sans-serif; font-size: 14px;">blog, Organic Chemistry International, Feedspot, Top 50 Chemistry Blogs, web, ANTHONY CRASTO, WORLDDRUGTRACKER, ORGANIC CHEMISTRY</span></div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com1tag:blogger.com,1999:blog-81273127788638440.post-75812818947964736242016-11-27T17:03:00.001+05:302016-11-27T17:03:37.444+05:30Improving the efficiency of the Diels-Alder process by using flow chemistry and zeolite catalysis<div dir="ltr" style="text-align: left;" trbidi="on">
<div>
<img align="center" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6GC02334G" height="138" style="background-color: #dddddd; font-family: helvetica, arial, sans-serif; font-size: 14px;" width="640" /></div>
<div>
<span style="font-family: "helvetica" , "arial" , sans-serif;"><span style="font-size: 14px;"><br /></span></span></div>
<div>
<span style="font-family: "helvetica" , "arial" , sans-serif;"><span style="font-size: 14px;"><br /></span></span></div>
<div>
<span style="font-family: "helvetica" , "arial" , sans-serif;"><span style="font-size: 14px;"><br /></span></span></div>
<ul style="background-color: #dddddd; font-family: helvetica, arial, sans-serif; font-size: 12px; list-style: none; margin: 0px; padding: 0px;">
<li class="regularitem" style="background: url("https://www.feedburner.com/fb/feed-styles/images/itemqube2.gif") left top no-repeat; margin: 0px 0px 16px; padding: 0px 6px 6px 24px;"><div class="itemcontent" name="decodeable" style="font-size: 14px; line-height: 18.2px; overflow: hidden; width: 693px;">
<a href="http://feeds.rsc.org/~r/rss/GC/~3/lH9SnodE8qE/C6GC02334G" style="color: #000099; font-size: 18px; letter-spacing: -0.25px; text-decoration: none;">Improving the efficiency of the Diels-Alder process by using flow chemistry and zeolite catalysis</a></div>
</li>
<li class="regularitem" style="background: url("https://www.feedburner.com/fb/feed-styles/images/itemqube2.gif") left top no-repeat; margin: 0px 0px 16px; padding: 0px 6px 6px 24px;"><div class="itemcontent" name="decodeable" style="font-size: 14px; line-height: 18.2px; overflow: hidden; width: 693px;">
<div>
<i><b>Green Chem.</b></i>, 2017, Advance Article<br />
<b>DOI</b>: 10.1039/C6GC02334G, Paper</div>
<div>
S. Seghers, L. Protasova, S. Mullens, J. W. Thybaut, C. V. Stevens<br />
The industrial application of the Diels-Alder reaction for the synthesis of (hetero)cyclic compounds constitutes an important challenge. To tackle the reagent instability problems and corresponding safety issues, the use of a high-pressure and zeolite catalysed microreactor process is presented.</div>
</div>
</li>
</ul>
<div>
<span style="background-color: white; color: #222222; font-family: "arial";">The industrial application of the Diels–Alder reaction for the atom-efficient synthesis of (hetero)cyclic compounds constitutes an important challenge. Safety and purity concerns, related to the instability of the polymerization prone diene and/or dienophile, limit the scalability of the production capacity of Diels–Alder products in a batch mode. To tackle these problems, the use of a high-pressure continuous microreactor process was considered. In order to increase the yields and the selectivity towards the </span><em style="background-color: white; color: #222222; font-family: arial;">endo</em><span style="background-color: white; color: #222222; font-family: "arial";">-isomer, commercially available zeolites were used as a heterogeneous catalyst in a microscale packed bed reactor. As a result, a high conversion (≥95%) and </span><em style="background-color: white; color: #222222; font-family: arial;">endo</em><span style="background-color: white; color: #222222; font-family: "arial";">-selectivity (89</span><img alt=" " border="0" src="http://www.rsc.org/images/entities/char_2009.gif" style="background-color: white; border: 0px; color: #222222; font-family: arial;" /><span style="background-color: white; color: #222222; font-family: "arial";">:</span><img alt=" " border="0" src="http://www.rsc.org/images/entities/char_2009.gif" style="background-color: white; border: 0px; color: #222222; font-family: arial;" /><span style="background-color: white; color: #222222; font-family: "arial";">11) were reached for the reaction of cyclopentadiene and methyl acrylate, using a 1</span><img alt=" " border="0" src="http://www.rsc.org/images/entities/char_2009.gif" style="background-color: white; border: 0px; color: #222222; font-family: arial;" /><span style="background-color: white; color: #222222; font-family: "arial";">:</span><img alt=" " border="0" src="http://www.rsc.org/images/entities/char_2009.gif" style="background-color: white; border: 0px; color: #222222; font-family: arial;" /><span style="background-color: white; color: #222222; font-family: "arial";">1 stoichiometry. A throughput of 0.87 g h</span><small style="background-color: white; color: #222222; font-family: arial;"><sup>−1</sup></small><span style="background-color: white; color: #222222; font-family: "arial";">during at least 7 h was reached, corresponding to a 3.5 times higher catalytic productivity and a 14 times higher production of Diels–Alder adducts in comparison to the heterogeneous lab-scale batch process. Catalyst deactivation was hardly observed within this time frame. Moreover, complete regeneration of the zeolite was demonstrated using a straightforward calcination procedure</span></div>
<div>
<span style="font-family: "helvetica" , "arial" , sans-serif;"><span style="font-size: 12px;"><br /></span></span></div>
<div>
<span style="font-family: "helvetica" , "arial" , sans-serif;"><span style="font-size: 12px;"><br /></span></span></div>
<div>
<div class="article_chemsoc_txt_s13" style="background-color: white; color: #003c73; float: left; font-family: arial, helvetica, sans-serif; font-size: 12px; line-height: 18px; margin-bottom: 5px; padding-left: 10px; padding-right: 10px; width: 520px;">
<h2 class="alpH1" style="color: #223335; float: left; font-family: museoslab700regular, arial; font-size: 21px; font-weight: normal; letter-spacing: 0em; line-height: 21px; margin: 16px 0px; padding: 0px;">
Improving the efficiency of the Diels–Alder process by using flow chemistry and zeolite catalysis</h2>
</div>
<div class="peptide_wrap_s10_left" style="background-color: white; float: left; height: auto; padding-left: 10px; padding-top: 5px; width: 320px;">
<div class="peptide_middle" style="float: left; line-height: 20px; width: 320px;">
<div style="font-family: Arial, Helvetica, sans-serif; font-size: 12px;">
<span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AS.%20Seghers" style="color: black; position: relative;">S. Seghers</a>,<sup>a</sup> </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AL.%20Protasova" style="color: black; position: relative;">L. Protasova</a>,<sup>b</sup> </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AS.%20Mullens" style="color: black; position: relative;">S. Mullens</a>,<sup>b</sup> </span><span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AJ.%20W.%20Thybaut" style="color: black; position: relative;">J. W. Thybaut</a><sup>c</sup> and </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AC.%20V.%20Stevens" style="color: black; position: relative;">C. V. Stevens</a><span style="font-size: 16px;">*</span><sup>a</sup> </span></div>
<div class="show_affiliation_section" id="aff_info" style="background-color: #f6f6f7; float: left; font-family: arial, helvetica, sans-serif; font-size: 12px; margin-bottom: 5px; padding: 0px 3px 10px 5px; width: 320px;">
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
*</div>
<div style="padding-left: 10px;">
Corresponding authors</div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">a</sup></div>
<div style="padding-left: 10px;">
SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium<br />
<b>E-mail: </b><a href="mailto:chris.stevens@ugent.be" style="color: #014682; position: relative;" title="chris.stevens@ugent.be">chris.stevens@ugent.be</a></div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">b</sup></div>
<div style="padding-left: 10px;">
VITO, Vlaamse Instelling voor Technologisch Onderzoek, Boeretang 200, 2400 Mol, Belgium</div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">c</sup></div>
<div style="padding-left: 10px;">
Laboratory for Chemical Technology, Department of Chemical Engineering and Technical Chemistry, Faculty of Engineering and Architecture, Ghent University, Technologiepark 914, 9052 Ghent, Belgium</div>
</div>
</div>
<div class="red_txt_s4" style="float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px; padding: 8px 0px 4px; width: 320px;">
<i><strong>Green Chem.</strong></i>, 2017, Advance Article</div>
<br />
<span class="DOILink" style="float: left; font-family: "arial" , "helvetica" , sans-serif; font-size: 12px; padding: 0px; width: 505px;"><strong>DOI: </strong>10.1039/C6GC02334G</span><span class="DOILink" style="float: left; font-family: "arial" , "helvetica" , sans-serif; font-size: 12px; padding: 0px; width: 505px;"><br /></span><span class="DOILink" style="float: left; padding: 0px; width: 505px;"><span style="font-family: "arial" , "helvetica" , sans-serif;"><span style="font-size: 12px;">http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C6GC02334G?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract</span></span></span><span class="DOILink" style="float: left; font-family: "arial" , "helvetica" , sans-serif; font-size: 12px; padding: 0px; width: 505px;"><br /></span><br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-96Pdim6Q_5I/WDrC9FKbMYI/AAAAAAAAWIU/6TKvokMgoNww2VxQfzquENcZPWneMlz3ACLcB/s1600/STR0.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="528" src="https://1.bp.blogspot.com/-96Pdim6Q_5I/WDrC9FKbMYI/AAAAAAAAWIU/6TKvokMgoNww2VxQfzquENcZPWneMlz3ACLcB/s640/STR0.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-HCnBZuaMLQw/WDrC9AMNI_I/AAAAAAAAWIM/FBRVg6YbQec78CC4Ppa3D0H6bGcatUmuQCLcB/s1600/STR1.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="212" src="https://3.bp.blogspot.com/-HCnBZuaMLQw/WDrC9AMNI_I/AAAAAAAAWIM/FBRVg6YbQec78CC4Ppa3D0H6bGcatUmuQCLcB/s640/STR1.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-Otshr5Hql5w/WDrC9ORdMII/AAAAAAAAWIQ/29WzeX529ZM1W6QyeEbfMWaamWthvZw4ACLcB/s1600/STR2.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="212" src="https://4.bp.blogspot.com/-Otshr5Hql5w/WDrC9ORdMII/AAAAAAAAWIQ/29WzeX529ZM1W6QyeEbfMWaamWthvZw4ACLcB/s640/STR2.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-UmixTB0apnA/WDrC953NruI/AAAAAAAAWIY/JblSp5HhqFgadBuO0w0jztabQmvCJZjJACLcB/s1600/STR3.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="390" src="https://3.bp.blogspot.com/-UmixTB0apnA/WDrC953NruI/AAAAAAAAWIY/JblSp5HhqFgadBuO0w0jztabQmvCJZjJACLcB/s640/STR3.JPG" width="640" /></a></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-QCi8mEC5aPE/WDrDedi0q1I/AAAAAAAAWIg/XRYiEWBfft4g4aZ3Gbw1eBxAY33xWkzlQCLcB/s1600/STR0.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="226" src="https://4.bp.blogspot.com/-QCi8mEC5aPE/WDrDedi0q1I/AAAAAAAAWIg/XRYiEWBfft4g4aZ3Gbw1eBxAY33xWkzlQCLcB/s640/STR0.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-ZfCQue2v4T4/WDrDeBWYSFI/AAAAAAAAWIc/kXdho-4jbuIw4JLvPrMMj4z2ZS-EiB_VACLcB/s1600/STR1.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="154" src="https://2.bp.blogspot.com/-ZfCQue2v4T4/WDrDeBWYSFI/AAAAAAAAWIc/kXdho-4jbuIw4JLvPrMMj4z2ZS-EiB_VACLcB/s640/STR1.JPG" width="640" /></a></div>
<span class="DOILink" style="float: left; font-family: "arial" , "helvetica" , sans-serif; font-size: 12px; padding: 0px; width: 505px;"><br /></span><span class="DOILink" style="float: left; font-family: "arial" , "helvetica" , sans-serif; font-size: 12px; padding: 0px; width: 505px;">///////////////////</span></div>
</div>
</div>
</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com0tag:blogger.com,1999:blog-81273127788638440.post-46760622320062952032016-10-28T12:59:00.000+05:302016-10-28T12:59:01.170+05:30Solvent- and halide-free synthesis of pyridine-2-yl substituted ureas through facile C-H functionalization of pyridine N-oxides<div dir="ltr" style="text-align: left;" trbidi="on">
<img align="center" height="206" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6GC02556K" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 18.2px;" width="640" /><br />
<br />
<h4 class="itemtitle" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 18px; letter-spacing: -0.25px; margin: 0px; padding: 0px;">
<a href="http://feeds.rsc.org/~r/rss/GC/~3/DHXeXqbjKA0/C6GC02556K" style="color: #000099; text-decoration: none;">Solvent- and halide-free synthesis of pyridine-2-yl substituted ureas through facile C-H functionalization of pyridine N-oxides</a></h4>
<h5 class="itemposttime" style="background-color: #dddddd; color: #666666; font-family: Helvetica, Arial, sans-serif; font-size: 14px; font-weight: normal; margin: 3px 0px 6px; padding: 0px;">
</h5>
<div class="itemcontent" name="decodeable" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 18.2px; overflow: hidden; width: 693px;">
<div>
<div style="margin-bottom: 1em; padding: 0px;">
</div>
</div>
<div>
<i><b>Green Chem.</b></i>, 2016, Advance Article<br /><b>DOI</b>: 10.1039/C6GC02556K, Paper</div>
<div>
Valentin A. Rassadin, Dmitry P. Zimin, Gulnara Z. Raskil'dina, Alexander Yu. Ivanov, Vadim P. Boyarskiy, Semen S. Zlotskii, Vadim Yu. Kukushkin<br />A solvent- and halide-free atom-economical synthesis of practically useful pyridine-2-yl substituted ureas utilizes pyridine <em>N</em>-oxides and dialkylcyanamides.</div>
</div>
<br />
<br />
<div class="article_chemsoc_txt_s13" style="background-color: white; color: #003c73; float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px; margin-bottom: 5px; padding-left: 10px; padding-right: 10px; width: 520px;">
<h2 class="alpH1" style="color: #223335; float: left; font-family: MuseoSlab700Regular, Arial; font-size: 21px; font-weight: normal; letter-spacing: 0em; line-height: 21px; margin: 16px 0px; padding: 0px;">
Solvent- and halide-free synthesis of pyridine-2-yl substituted ureas through facile C–H functionalization of pyridine <em>N</em>-oxides</h2>
</div>
<div class="peptide_wrap_s10_left" style="background-color: white; float: left; font-family: arial; font-size: 12px; height: auto; line-height: 16px; padding-left: 10px; padding-top: 5px; width: 320px;">
<div class="peptide_middle" style="float: left; font-family: Arial, Helvetica, sans-serif; line-height: 20px; width: 320px;">
<div>
<span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AValentin%20A.%20Rassadin" style="color: black; position: relative;">Valentin A. Rassadin</a>,<span style="font-size: 16px;">*</span><sup>a</sup> </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3ADmitry%20P.%20Zimin" style="color: black; position: relative;">Dmitry P. Zimin</a>,<sup>a</sup> </span><span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AGulnara%20Z.%20Raskil%27dina" style="color: black; position: relative;">Gulnara Z. Raskil'dina</a>,<sup>a</sup><sup>b</sup> </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AAlexander%20Yu.%20Ivanov" style="color: black; position: relative;">Alexander Yu. Ivanov</a>,<sup>c</sup> </span><span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AVadim%20P.%20Boyarskiy" style="color: black; position: relative;">Vadim P. Boyarskiy</a>,<sup>a</sup> </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3ASemen%20S.%20Zlotskii" style="color: black; position: relative;">Semen S. Zlotskii</a><sup>b</sup> and </span><span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AVadim%20Yu.%20Kukushkin" style="color: black; position: relative;">Vadim Yu. Kukushkin</a><span style="font-size: 16px;">*</span><sup>a</sup> </span></div>
<div style="clear: left;">
</div>
<div class="show_aff" style="margin: 16px 0px;">
</div>
<div class="show_affiliation_section" id="aff_info" style="background-color: #f6f6f7; float: left; margin-bottom: 5px; padding: 0px 3px 10px 5px; width: 320px;">
<div>
<br /></div>
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
*</div>
<div style="padding-left: 10px;">
Corresponding authors</div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">a</sup></div>
<div style="padding-left: 10px;">
Institute of Chemistry, Saint Petersburg State University, Universitetskaya Nab. 7/9, 199034 Saint Petersburg, Russia<br /><b>E-mail: </b><a href="mailto:v.rassadin@spbu.ru" style="color: #014682; position: relative; text-decoration: none;" title="v.rassadin@spbu.ru">v.rassadin@spbu.ru</a>, <a href="mailto:v.kukushkin@spbu.ru" style="color: #014682; position: relative; text-decoration: none;" title="v.kukushkin@spbu.ru">v.kukushkin@spbu.ru</a></div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">b</sup></div>
<div style="padding-left: 10px;">
Ufa State Petroleum Technological University, Kosmonavtov 1, Ufa, Bashkortostan, Russia</div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 320px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">c</sup></div>
<div style="padding-left: 10px;">
Research Park SPbSU, Center for Magnetic Resonance, Saint Petersburg State University, Universitetskaya Nab. 7/9, 199034 Saint Petersburg, Russia</div>
</div>
</div>
<div class="red_txt_s4" style="float: left; line-height: 18px; padding: 8px 0px 4px; width: 320px;">
<i><strong>Green Chem.</strong></i>, 2016, Advance Article</div>
<br /><span class="DOILink" style="float: left; padding: 0px; width: 505px;"><strong>DOI: </strong>10.1039/C6GC02556K</span></div>
</div>
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<span style="background-color: white; color: #222222; font-family: Arial; line-height: 18px;">A novel solvent- and halide-free atom-economical synthesis of practically useful pyridine-2-yl substituted ureas utilizes easily accessible or commercially available pyridine </span><em style="background-color: white; color: #222222; font-family: Arial; line-height: 18px;">N</em><span style="background-color: white; color: #222222; font-family: Arial; line-height: 18px;">-oxides (PyO) and dialkylcyanamides. The observed C–H functionalization of PyO is suitable for the good-to-high yielding synthesis of a wide range of pyridine-2-yl substituted ureas featuring electron donating and electron withdrawing, sensitive, or even fugitive functional groups at any position of the pyridine ring (63–92%; 19 examples). In the cases of 3-substituted PyO, the C–H functionalization occurs regioselectively providing a route for facile generation of ureas bearing a 5-substituted pyridine-2-yl moiety.</span><br />
<br />
<br />
<br />
1,1-Dimethyl-3-(pyridin-2-yl)urea<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-LV1-sxDpkRc/WBL98HRNq6I/AAAAAAAAU8A/M_bNTdkTfWM8c1D1BcT2dzOtFhyKkoLWACLcB/s1600/STR1.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="140" src="https://2.bp.blogspot.com/-LV1-sxDpkRc/WBL98HRNq6I/AAAAAAAAU8A/M_bNTdkTfWM8c1D1BcT2dzOtFhyKkoLWACLcB/s640/STR1.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-YoIjdgximHM/WBL98ITkqZI/AAAAAAAAU74/zYlHmtPqyoAzVyz37p8rAA2cjzDTpu1vQCLcB/s1600/STR2.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="258" src="https://2.bp.blogspot.com/-YoIjdgximHM/WBL98ITkqZI/AAAAAAAAU74/zYlHmtPqyoAzVyz37p8rAA2cjzDTpu1vQCLcB/s640/STR2.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
</div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-v7E-JKeZJlU/WBL98u482DI/AAAAAAAAU8E/9VPKSPbLv4wWLUUfkZq-EFQjwa0XDdalwCLcB/s1600/str4.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="448" src="https://4.bp.blogspot.com/-v7E-JKeZJlU/WBL98u482DI/AAAAAAAAU8E/9VPKSPbLv4wWLUUfkZq-EFQjwa0XDdalwCLcB/s640/str4.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-7nfiBmHYfW8/WBL98zNqYCI/AAAAAAAAU8I/kCuNQmA3E_U84PxLRZ0vmEEasFYW14UgACLcB/s1600/str5.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="424" src="https://1.bp.blogspot.com/-7nfiBmHYfW8/WBL98zNqYCI/AAAAAAAAU8I/kCuNQmA3E_U84PxLRZ0vmEEasFYW14UgACLcB/s640/str5.JPG" width="640" /></a></div>
<br />
<br />
1,1-Dimethyl-3-(pyridin-2-yl)urea (4a)3
: From pyridine 1-oxide (1a) (95.0 mg, 1.00
mmol) and dimethylcyanamide (2a) (105 mg, 1.50 mmol), compound 4a (147 mg,
89%) was obtained according to GP1 as a yellow oil, which was then crystalized in
the freezer to give pale yellow solid, m.p. = 42.6–43.5 °C, lit.4 m.p. = 44–47 °C (EtOAc/hexane), Rf
= 0.25 (EtOAc). 1H NMR (400 MHz, CDCl3): δ = 3.00 (s, 6 H, NCH3), 6.88 (ddd, J = 7.3, 5.0, 0.9
Hz, 1 H), 7.30 (br. s, 1 H), 7.60 (ddd, J = 8.5, 7.3, 1.9 Hz, 1 H), 8.02 (dt, J = 8.5, 0.9 Hz, 1 H), 8.14
(ddd, J = 5.0, 1.9, 0.9 Hz, 1 H) ppm. 13C NMR (101 MHz, CDCl3): δ = 36.3 (2 С, CH3), 113.0 (CH),
118.1 (CH), 138.0 (CH), 147.3 (CH), 152.8 (C), 154.8 (C) ppm. NMR data are consistent with
previously reported.3 HRMS (ESI), m/z: [M + H]+ calcd. for C8H12N3O+
: 166.0975; found: 166.0977.<br />
<br />
<br />
<a href="http://www.rsc.org/suppdata/c6/gc/c6gc02556k/c6gc02556k1.pdf">///////</a>/////</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com1tag:blogger.com,1999:blog-81273127788638440.post-9351951830132128082016-10-09T19:37:00.002+05:302016-10-09T19:39:14.846+05:30ENZYMES AS GREEN CATALYSTS FOR PHARMACEUTICAL INDUSTRY<div dir="ltr" style="text-align: left;" trbidi="on">
<div dir="ltr" style="text-align: left;" trbidi="on">
<br /></div>
<img alt="Image result for Novozymes" src="http://aws-master.s3.amazonaws.com/wp-content/uploads/2014/07/novozymes.png" height="244" width="640" />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
ENZYMES AS GREEN CATALYSTS FOR PHARMACEUTICAL INDUSTRY<br />
<a href="http://industrialgreenchem.com/pdf-docs/presentations/Hyderabad%20Event%202015/ENZYMES%20AS%20GREEN%20CATALYSTS%20FOR%20PHARMACUETICAL%20INDUSTRY%20by%20Dinesh%20Nair.pdf"><strong>'Green' Catalysts for 'greener' reactions </strong></a>
- Dr. Dinesh Nair, Regional Business Manager at Novozymes South Asia Pvt. Ltd
<br />
<br />
<br />
<iframe frameborder="0" height="588" scrolling="no" src="https://onedrive.live.com/embed?cid=FC3071A5D7797DD2&resid=FC3071A5D7797DD2%21638&authkey=ANAo4HdvtDS7xPc&em=2" width="776"></iframe>
<br />
<br />
<br />
<br />
<br />
<img alt="Image result for Novozymes" height="426" src="https://upload.wikimedia.org/wikipedia/en/c/c1/Novozymes_Bagsvaerd,_Copenhagen_HQ.jpg" width="640" />
<br />
<br />
<br />
<br />
/////////Novozymes, ENZYMES, GREEN CATALYSTS, PHARMACEUTICAL INDUSTRY, <a href="http://industrialgreenchem.com/pdf-docs/presentations/Hyderabad%20Event%202015/ENZYMES%20AS%20GREEN%20CATALYSTS%20FOR%20PHARMACUETICAL%20INDUSTRY%20by%20Dinesh%20Nair.pdf"><strong>'Green' Catalysts, 'greener' reactions </strong></a></div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com0tag:blogger.com,1999:blog-81273127788638440.post-29245530128106181442016-09-25T19:13:00.000+05:302016-09-26T06:31:44.076+05:30A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives<div dir="ltr" style="text-align: left;" trbidi="on">
<img alt="Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/Articleimage/2016/GC/c6gc01125j/c6gc01125j-u8_hi-res.gif" height="168" width="200" /><br />
<br />
<br />
<br />
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-htD5SCZR17I/V-fQ2n6NpUI/AAAAAAAAUK4/6hu2-KDEasYI0LUgDDW8HbC9br7O9m9-ACLcB/s1600/str1.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="346" src="https://3.bp.blogspot.com/-htD5SCZR17I/V-fQ2n6NpUI/AAAAAAAAUK4/6hu2-KDEasYI0LUgDDW8HbC9br7O9m9-ACLcB/s640/str1.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-Y1-TKAU0ocg/V-fQ2oSIH_I/AAAAAAAAUK8/dN5H6j0u4BAczvqcv6yDeQ-_SIzJuRKRQCLcB/s1600/str2.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="326" src="https://4.bp.blogspot.com/-Y1-TKAU0ocg/V-fQ2oSIH_I/AAAAAAAAUK8/dN5H6j0u4BAczvqcv6yDeQ-_SIzJuRKRQCLcB/s640/str2.JPG" width="640" /></a></div>
<br />
<br />
<div style="background-color: white; color: #222222; font-family: Arial; text-align: left;" xmlns="http://www.rsc.org/schema/rscart38">
A highly efficient and green method has been developed for the rapid preparation of highly functionalized isoxazolopyridin-3-amine derivatives in excellent yields. This process has a broad substrate scope, is operationally simple, and generally requires no chromatographic purification. In addition, the process is scalable and significantly greener than current alternatives with a PMI of 18 and water as the reaction solvent.</div>
<br />
<br style="background-color: white; color: #222222; font-family: Arial; font-size: 12px;" />
<br />
<div align="center" class="abstract_new_img" style="background-color: white; color: #222222; float: left; font-family: Arial; font-size: 12px; width: 480px;">
<img alt="Graphical abstract: A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6GC01125J" id="imgGALoader" style="border: 0px;" title="Graphical abstract" /></div>
<div align="center" class="abstract_new_img" style="background-color: white; color: #222222; float: left; font-family: Arial; font-size: 12px; width: 480px;">
<br /></div>
<div align="center" class="abstract_new_img" style="background-color: white; color: #222222; float: left; font-family: Arial; font-size: 12px; width: 480px;">
<br /></div>
<div align="center" class="abstract_new_img" style="background-color: white; color: #222222; float: left; font-family: Arial; font-size: 12px; width: 480px;">
<img alt="Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/Articleimage/2016/GC/c6gc01125j/c6gc01125j-u2_hi-res.gif" height="211" width="640" /></div>
<div align="center" class="abstract_new_img" style="background-color: white; color: #222222; float: left; font-family: Arial; font-size: 12px; width: 480px;">
<br /></div>
<div align="center" class="abstract_new_img" style="background-color: white; color: #222222; float: left; font-family: Arial; font-size: 12px; width: 480px;">
<img alt="Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/Articleimage/2016/GC/c6gc01125j/c6gc01125j-s1_hi-res.gif" height="248" width="640" /></div>
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<img alt="Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/Articleimage/2016/GC/c6gc01125j/c6gc01125j-s2_hi-res.gif" height="416" width="640" /><br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<h4 class="itemtitle" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 18px; letter-spacing: -0.25px; margin: 0px; padding: 0px;">
</h4>
<div class="itemcontent" name="decodeable" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 18.2px; overflow: hidden; width: 693px;">
<div>
<br /></div>
<div>
<br /></div>
<div>
<img alt="Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/Articleimage/2016/GC/c6gc01125j/c6gc01125j-u5_hi-res.gif" height="171" width="640" /></div>
<div>
<br /></div>
<div>
<br /></div>
<div>
<img alt="Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/Articleimage/2016/GC/c6gc01125j/c6gc01125j-s3_hi-res.gif" height="244" width="640" /></div>
<div>
<br /></div>
<div>
<br /></div>
<div>
<br /></div>
<div>
A rapid preparation of highly functionalized isoxazolopyridin-3-amine and other heterocyclic fused aminoisoxazole derivatives</div>
</div>
<br />
<br />
<div class="article_chemsoc_txt_s13" style="background-color: white; color: #003c73; float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px; margin-bottom: 5px; padding-left: 10px; padding-right: 10px; width: 520px;">
<h2 class="alpH1" style="float: left; font-family: Arial; font-size: 14px; font-weight: normal; letter-spacing: 0em; line-height: 21px; margin: 0px; padding: 0px;">
A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives</h2>
</div>
<div class="peptide_wrap_s10_left" style="background-color: white; float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; height: auto; padding-left: 10px; padding-top: 5px; width: 370px;">
<div class="peptide_middle" style="float: left; line-height: 20px; width: 360px;">
<div>
<span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AWensheng%20Yu" style="color: black; position: relative;">Wensheng Yu</a>,<span style="font-size: 16px;">*</span><sup>a</sup> </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3APaul%20G.%20Bulger" style="color: black; position: relative;">Paul G. Bulger</a><sup>b</sup> and </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AKevin%20M.%20Maloney" style="color: black; position: relative;">Kevin M. Maloney</a><span style="font-size: 16px;">*</span><sup>b</sup> </span></div>
<div style="clear: left;">
</div>
<div class="show_aff" style="margin: 5px 0px 4px;">
</div>
<div class="show_affiliation_section" id="aff_info" style="background-color: #eef1f6; float: left; margin-bottom: 5px; padding: 0px 3px 10px 5px; width: 360px;">
<div>
<br /></div>
<div class="show_aff_content" style="padding-top: 5px; width: 360px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
*</div>
<div style="padding-left: 10px;">
Corresponding authors</div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 360px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">a</sup></div>
<div style="padding-left: 10px;">
Discovery Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, USA<br />
<b>E-mail: </b><a href="mailto:wensheng.yu@merck.com" style="color: #014682; position: relative; text-decoration: none;" title="wensheng.yu@merck.com">wensheng.yu@merck.com</a></div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 360px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">b</sup></div>
<div style="padding-left: 10px;">
Process Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, USA</div>
</div>
</div>
<div class="red_txt_s4" style="float: left; line-height: 18px; width: 360px;">
<i><strong>Green Chem.</strong></i>, 2016,<span style="padding-right: 2px;"></span><strong>18</strong>, 4941-4946</div>
<br />
<span class="DOILink" style="float: left; padding: 0px; width: 505px;"><strong>DOI: </strong>10.1039/C6GC01125J</span></div>
</div>
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<a href="https://www.blogger.com/goog_585893946"><br /></a>
<a href="http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01125J?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract">http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01125J?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract</a><br />
<br />
<br />
<img alt="Wensheng Yu" height="400" src="https://media.licdn.com/media/p/1/005/03b/0ab/3ee7822.jpg" width="400" /><br />
<br />
<br />
<div data-li-template="name" id="name-container" style="background-color: white; border: 0px; color: #333333; font-family: Arial, sans-serif; font-size: 12px; font-stretch: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div class="editable-item" id="name" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<h1 style="border: 0px; font-family: inherit; font-size: 12px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<span class="fn" style="border: 0px; color: black; font-family: inherit; font-size: 26px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: bold; line-height: 30px; margin: 0px; padding: 0px; vertical-align: baseline;"><span class="full-name" dir="auto" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Wensheng Yu</span></span></h1>
</div>
</div>
<div data-li-template="headline" id="headline-container" style="background-color: white; border: 0px; color: #333333; font-family: Arial, sans-serif; font-size: 12px; font-stretch: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div class="editable-item" id="headline" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div class="title" dir="ltr" style="border: 0px; display: inline; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 20px; padding: 1px 0px; text-size-adjust: 100%; vertical-align: baseline;">
Associate Principal Scientist at Merck</div>
</div>
<div class="editable-item" id="headline" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div class="title" dir="ltr" style="border: 0px; display: inline; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 20px; padding: 1px 0px; text-size-adjust: 100%; vertical-align: baseline;">
<br /></div>
</div>
</div>
<br />
<br />
<img alt="Image result for Paul G. Bulger merck" src="http://orgsyn.org/content/authors/V87P0008pgbulger.jpg" /><br />
<br />
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;">Paul G. Bulger was born in London, England, in 1978. He received his undergraduate M.Chem degree in 2000 from the University of Oxford, completing his Part II project under the supervision of Dr. Mark G. Moloney. He remained at Oxford for his graduate studies, obtaining his D. Phil. in chemistry in 2003 for research conducted under the supervision of Professor Sir Jack E. Baldwin. After an enjoyable three-year stint as a postdoctoral researcher in Professor K. C. Nicolaou's group at The Scripps Research Institute, he joined the Process Research Department of Merck & Co., Inc. in the fall of 2006.</span><br />
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;"><br /></span>
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;"><br /></span>
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;"><br /></span>
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;"><br /></span>
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;"><br /></span>
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;"><br /></span>
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;">pic not available</span><br />
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;"><br /></span>
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;"><br /></span>
<br />
<div data-li-template="name" id="name-container" style="background-color: white; border: 0px; color: #333333; font-family: Arial, sans-serif; font-size: 12px; font-stretch: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div class="editable-item" id="name" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<h1 style="border: 0px; font-family: inherit; font-size: 12px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<span class="fn" style="border: 0px; color: black; font-family: inherit; font-size: 26px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: bold; line-height: 30px; margin: 0px; padding: 0px; vertical-align: baseline;"><span class="full-name" dir="auto" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Kevin Maloney</span></span></h1>
</div>
</div>
<div data-li-template="headline" id="headline-container" style="background-color: white; border: 0px; color: #333333; font-family: Arial, sans-serif; font-size: 12px; font-stretch: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div class="editable-item" id="headline" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div class="title" dir="ltr" style="border: 0px; display: inline; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 20px; padding: 1px 0px; text-size-adjust: 100%; vertical-align: baseline;">
Sr Research Chemist at Merck Sharp & Dohme</div>
</div>
</div>
<span style="background-color: white; font-family: "verdana" , "tahoma" , "arial" , sans-serif; font-size: 13.3333px; text-align: justify;"><br /></span>
<br />
<div class="background-section" data-li-template="experience_section" id="background-experience-container" style="background-color: white; border: 0px; color: #333333; font-family: Arial, sans-serif; font-size: 13px; font-stretch: inherit; font-variant-numeric: inherit; line-height: 17px; margin: 0px; padding: 0px; position: relative; text-size-adjust: 100%; vertical-align: baseline;">
<div class="background-experience edit-default" id="background-experience" style="border-bottom-color: rgb(232, 232, 232); border-bottom-style: solid; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 28px 0px 8px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<h3 style="border: 0px; color: #434649; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: normal; line-height: 18px; margin: 0px 0px 23px; padding: 10px 0px; text-size-adjust: 100%; vertical-align: baseline;">
Experience</h3>
<div class="editable-item section-item current-position" id="experience-135251071" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 30px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div id="experience-135251071-view" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<br />
<header style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><h5 aria-hidden="true" class="experience-logo" style="border: 0px; color: #434649; float: right; font-family: inherit; font-size: 14px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: normal; line-height: 16px; margin: -2px 0px 0px; padding: 0px; text-align: center; text-size-adjust: 100%; vertical-align: baseline; width: 100px;">
<a href="https://www.linkedin.com/company/1486?trk=prof-exp-company-name" style="border: 0px; color: #434649; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 16px; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;"><img alt="" class="lazy-load" data-li-src="https://media.licdn.com/media/p/3/000/06a/3d6/0507405.png" src="https://media.licdn.com/media/p/3/000/06a/3d6/0507405.png" style="border: none; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;" /></a></h5>
<h4 style="border: 0px; color: black; display: inline; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 18px; margin: 0px 0px 4px; padding: 0px; text-size-adjust: 100%; vertical-align: middle; zoom: 1;">
<a href="https://www.linkedin.com/title/sr-research-chemist?trk=mprofile_title" style="border: 0px; color: black; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 18px; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;" title="Learn more about this title">Sr Research Chemist</a></h4>
<h5 style="border: 0px; color: #434649; font-family: inherit; font-size: 14px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: normal; line-height: 16px; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<span class="new-miniprofile-container /biz/miniprofile/1486?pathWildcard=1486" data-li-getjs="https://static.licdn.com/scds/concat/common/js?h=40vfeoewuurexnhvi1o2qiknu&fc=2" data-li-miniprofile-id="LI-3870049" data-li-url="/biz/miniprofile/1486?pathWildcard=1486" data-tracking="mcp_profile_sum" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><span style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><a dir="auto" href="https://www.linkedin.com/company/1486?trk=prof-exp-company-name" style="border: 0px; color: #434649; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 16px; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;">Merck Sharp & Dohme</a></span></span></h5>
</header><span class="experience-date-locale" style="border: 0px; color: #66696a; display: block; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: 17px; margin: 3px 0px 0px; padding: 0px; vertical-align: baseline;"></span></div>
</div>
<div class="editable-item section-item current-position" id="experience-152391730" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 30px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div id="experience-152391730-view" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<br />
<header style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><h5 aria-hidden="true" class="experience-logo" style="border: 0px; color: #434649; float: right; font-family: inherit; font-size: 14px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: normal; line-height: 16px; margin: -2px 0px 0px; padding: 0px; text-align: center; text-size-adjust: 100%; vertical-align: baseline; width: 100px;">
<a href="https://www.linkedin.com/company/1486?trk=prof-exp-company-name" style="border: 0px; color: #434649; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 16px; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;"><img alt="" class="lazy-load" data-li-src="https://media.licdn.com/media/p/3/000/06a/3d6/0507405.png" src="https://media.licdn.com/media/p/3/000/06a/3d6/0507405.png" style="border: none; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;" /></a></h5>
<h4 style="border: 0px; color: black; display: inline; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 18px; margin: 0px 0px 4px; padding: 0px; text-size-adjust: 100%; vertical-align: middle; zoom: 1;">
<a href="https://www.linkedin.com/title/sr-research-chemist?trk=mprofile_title" style="border: 0px; color: black; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 18px; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;" title="Learn more about this title">Sr Research Chemist</a></h4>
<h5 style="border: 0px; color: #434649; font-family: inherit; font-size: 14px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: normal; line-height: 16px; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<span class="new-miniprofile-container /biz/miniprofile/1486?pathWildcard=1486" data-li-getjs="https://static.licdn.com/scds/concat/common/js?h=40vfeoewuurexnhvi1o2qiknu&fc=2" data-li-url="/biz/miniprofile/1486?pathWildcard=1486" data-tracking="mcp_profile_sum" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><span style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><a dir="auto" href="https://www.linkedin.com/company/1486?trk=prof-exp-company-name" style="border: 0px; color: #434649; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 16px; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;">Merck</a></span></span></h5>
</header><span class="experience-date-locale" style="border: 0px; color: #66696a; display: block; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: 17px; margin: 3px 0px 0px; padding: 0px; vertical-align: baseline;"><time style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">2007</time> – Present (9 years)</span></div>
</div>
</div>
</div>
<div class="background-section" data-li-template="education_section" id="background-education-container" style="background-color: white; border: 0px; color: #333333; font-family: Arial, sans-serif; font-size: 13px; font-stretch: inherit; font-variant-numeric: inherit; line-height: 17px; margin: 0px; padding: 0px; position: relative; text-size-adjust: 100%; vertical-align: baseline;">
<div class="background-education edit-default last" id="background-education" style="border-bottom-style: solid; border-color: transparent; border-image: initial; border-left-style: initial; border-right-style: initial; border-top-style: initial; border-width: 0px 0px 1px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 28px 0px 8px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<h3 style="border: 0px; color: #434649; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: normal; line-height: 18px; margin: 0px 0px 23px; padding: 10px 0px; text-size-adjust: 100%; vertical-align: baseline;">
Education</h3>
<div class="editable-item section-item" id="education-61273387" style="border: 0px; clear: both; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 30px; min-height: 60px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div id="education-61273387-view" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<div class="education first" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;">
<a href="https://www.linkedin.com/edu/school?id=18494&trk=prof-edu-school-logo" style="border: 0px; color: #96999c; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;" title="More details for this school"></a><br />
<h5 aria-hidden="true" class="education-logo" style="border: 0px; color: #434649; float: right; font-family: inherit; font-size: 14px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: normal; line-height: 16px; margin: -2px 0px 0px; padding: 0px; text-align: center; text-size-adjust: 100%; vertical-align: baseline; width: 100px;">
<a href="https://www.linkedin.com/edu/school?id=18494&trk=prof-edu-school-logo" style="border: 0px; color: #96999c; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;" title="More details for this school">
<span class="new-miniprofile-container /edu/school-rich-mini-profile?id=18494&entityId=18494&entityType=SCHOOL" data-li-tl="tl/apps/plato/embed/home/school_mini_profile" data-li-url="/edu/school-rich-mini-profile?id=18494&entityId=18494&entityType=SCHOOL" data-tracking="" style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><img alt="Massachusetts Institute of Technology" class="lazy-load" data-li-src="https://media.licdn.com/mpr/mpr/shrink_100_100/AAEAAQAAAAAAAASzAAAAJDhlMWU4MDQ4LWUwZGYtNDM2Yi1hNTIyLWY2MTUzZDdlNTg3MQ.png" height="60" src="https://media.licdn.com/mpr/mpr/shrink_100_100/AAEAAQAAAAAAAASzAAAAJDhlMWU4MDQ4LWUwZGYtNDM2Yi1hNTIyLWY2MTUzZDdlNTg3MQ.png" style="border: none; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-size-adjust: 100%; vertical-align: baseline;" width="60" /></span></a></h5>
<a href="https://www.linkedin.com/edu/school?id=18494&trk=prof-edu-school-logo" style="border: 0px; color: #96999c; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;" title="More details for this school">
</a><header style="border: 0px; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><h4 class="summary fn org" dir="auto" style="border: 0px; color: black; display: inline; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 18px; margin: 0px 0px 4px; padding: 0px; text-size-adjust: 100%; vertical-align: middle; zoom: 1;">
<a href="https://www.linkedin.com/edu/school?id=18494&trk=prof-edu-school-name" style="border: 0px; color: black; font-family: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: 18px; margin: 0px; padding: 0px; text-decoration: none; text-size-adjust: 100%; vertical-align: baseline;" title="More details for this school">Massachusetts Institute of Technology</a></h4>
</header></div>
</div>
</div>
</div>
</div>
<br />
/////////////</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com1tag:blogger.com,1999:blog-81273127788638440.post-61501625626716322382016-09-23T14:02:00.000+05:302016-09-23T14:02:27.307+05:30A Simple and Versatile Reactor for Photochemistry<div dir="ltr" style="text-align: left;" trbidi="on">
<img alt="Abstract Image" height="276" src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/oprdfk/0/oprdfk.ahead-of-print/acs.oprd.6b00257/20160921/images/medium/op-2016-00257d_0007.gif" width="640" /><br />
<span style="background-color: #f4f9fd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 22.4px;">A photoreactor that generates a thin film upon rotation for efficient irradiation of solutions is described. The reactor is based around a standard piece of equipment found in most synthetic laboratories, namely, a rotary evaporator. Three different photo-oxidation reactions have been used to examine the effects of several parameters such as irradiated volume, flask size, rotation speed, and light intensity. The reactor can be operated in a semicontinuous manner, and two possible configurations are described. The thickness of the generated film and the rate of mixing under different conditions have been examined using in situ electronic absorption spectroscopy.</span><br />
<span style="background-color: #f4f9fd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 22.4px;"><br /></span>
Safety warning: Any experiment involving flammable organic solvents and air or pure
oxygen is potentially hazardous, especially when partially contained, as is the case of the
flask of our reactor. We took the following precautions and encountered no problems but we
stress the need for readers to make safety assessments for their own experiments as peripheral
circumstances may be different from ours. All experiments were carried out in a fume hood
or ventilated enclosure with adequate ventilation and the front lowered. Any obvious sources
of ignition were removed. Oxygen was fed from a cylinder fitted with a compliant regulator
and was delivered at a maintained pressure of 1 bar using a mass flow controller compatible
with oxygen. The equipment was maintained and cleaned free of grease at all times to
prevent any incompatibilities with oxygen. Temperatures were kept at ambient. When
working above the solvent flash point and LOC, care must be taken to ensure that all possible
risks have been considered. Appropriate safeguards and suitable safety measures must be
implemented.<br />
<span style="background-color: #f4f9fd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 22.4px;"><br /></span>
<span style="background-color: #f4f9fd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 22.4px;"><br /></span>
<span style="background-color: #f4f9fd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 22.4px;"><br /></span>
<span style="background-color: #f4f9fd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 22.4px;"><br /></span>
<h1 class="articleTitle" style="background-color: white; font-family: Helvetica, Arial, sans-serif; font-size: 20px; margin-top: 0px;">
<span class="hlFld-Title">A Simple and Versatile Reactor for Photochemistry</span></h1>
<div id="articleMeta" style="background-color: white; margin-bottom: 30px; margin-top: 15px;">
<div id="authors" style="color: #333333; font-family: Helvetica, Arial, sans-serif; font-size: 1em; font-weight: bold; line-height: 1.3em;">
<span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Clark%2C+Charlotte+A" id="authors" style="border-bottom-color: rgb(51, 102, 153); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 1em; text-decoration: none;">Charlotte A. Clark</a></span><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00257#aff4" style="color: #336699; text-decoration: none;">†</a><span class="NLM_x"><x xml:space="preserve" xmlns:acs="http://namespace.acs.org/2008/acs" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">, </x></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Lee%2C+Darren+S" id="authors" style="border-bottom-color: rgb(51, 102, 153); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 1em; text-decoration: none;">Darren S. Lee</a></span><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00257#aff4" style="color: #336699; text-decoration: none;">†</a><span class="NLM_x"><x xml:space="preserve" xmlns:acs="http://namespace.acs.org/2008/acs" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">, </x></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Pickering%2C+Stephen+J" id="authors" style="border-bottom-color: rgb(51, 102, 153); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 1em; text-decoration: none;">Stephen J. Pickering</a></span><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00257#aff4" style="color: #336699; text-decoration: none;">‡</a><span class="NLM_x"><x xml:space="preserve" xmlns:acs="http://namespace.acs.org/2008/acs" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">, </x></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Poliakoff%2C+Martyn" id="authors" style="border-bottom-color: rgb(51, 102, 153); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 1em; text-decoration: none;">Martyn Poliakoff</a></span><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00257#cor1" style="color: #336699; text-decoration: none;"><span style="font-size: 0.8em; line-height: 0.8em; vertical-align: 0.4em;">*</span></a><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00257#aff4" style="color: #336699; text-decoration: none;">†</a><span class="NLM_x"><x xml:space="preserve" xmlns:acs="http://namespace.acs.org/2008/acs" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">, and </x></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/George%2C+Michael+W" id="authors" style="border-bottom-color: rgb(51, 102, 153); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 1em; text-decoration: none;">Michael W. George</a></span><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00257#cor2" style="color: #336699; text-decoration: none;"><span style="font-size: 0.8em; line-height: 0.8em; vertical-align: 0.4em;">*</span></a><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00257#aff4" style="color: #336699; text-decoration: none;">†</a><span class="NLM_xref-aff"><span style="font-size: 0.8em; line-height: 0.8em; vertical-align: 0.4em;">§</span></span><span class="NLM_x"></span></span></div>
<div class="affiliations" style="font-family: Helvetica, Arial, sans-serif; font-size: 13px; line-height: 1.3em;">
<div id="aff4">
<span style="font-size: 0.8em; line-height: 0.8em; vertical-align: 0.4em;">†</span>School of Chemistry, <span style="font-size: 0.8em; line-height: 0.8em; vertical-align: 0.4em;">‡</span>Department of Mechanical, Materials and Manufacturing Engineering, <span class="institution">The University of Nottingham</span>, University Park, Nottingham NG7 2RD, <span class="country">United Kingdom</span></div>
<div id="aff3">
<span style="font-size: 0.8em; line-height: 0.8em; vertical-align: 0.4em;">§</span> Department of Chemical and Environmental Engineering, <span class="institution">The University of Nottingham Ningbo China</span>, 199 Taikang East Road, Ningbo 315100, <span class="country">China</span></div>
</div>
<div id="citation" style="font-family: Helvetica, Arial, sans-serif; font-size: 0.9em; line-height: 1.3em; margin: 10px 0px 0px;">
<cite>Org. Process Res. Dev.</cite>, Article ASAP</div>
<div id="doi" style="font-family: Helvetica, Arial, sans-serif; font-size: 0.9em; line-height: 1.3em;">
<strong>DOI: </strong>10.1021/acs.oprd.6b00257</div>
<div id="pubDate">
<span style="font-family: Helvetica, Arial, sans-serif;"><span style="font-size: 11.7px; line-height: 16.9px;"><a href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00257">http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00257</a></span></span></div>
<div id="correspondence" style="color: #666666; font-family: Helvetica, Arial, sans-serif; font-size: 0.9em; line-height: 1.3em; margin: 7px 0px 0px; width: auto;">
*E-mail: <a href="mailto:martyn.poliakoff@nottingham.ac.uk" style="color: #336699; text-decoration: none;">martyn.poliakoff@nottingham.ac.uk</a> (M.P.)., *E-mail: <a href="mailto:mike.george@nottingham.ac.uk" style="color: #336699; text-decoration: none;">mike.george@nottingham.ac.uk</a> (M.W.G.).</div>
</div>
<span style="background-color: #f4f9fd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 22.4px;"><br /></span>
<span style="background-color: #f4f9fd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 22.4px;">//////////</span></div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com0tag:blogger.com,1999:blog-81273127788638440.post-17095892184384780652016-09-19T07:25:00.000+05:302016-09-19T07:33:38.590+05:30Solid-Phase Peptide Synthesis of Dipeptide (Histidine-β-Alanine) as a Chelating Agent by Using Trityl Chloride Resin, for Removal of Al3+, Cu2+, Hg2+ and Pb2+: Experimental and Theoretical Study<div dir="ltr" style="text-align: left;" trbidi="on">
<img src="http://jbcs.sbq.org.br/imageBank/images/151251AR-GA.jpg" height="640" width="568" /><br />
<br />
<br />
Characterization of synthesised dipeptide (histidine-β-
alanine)
Dipeptide was successfully synthesized via the standard
BOC method. The synthesis of dipeptide (histidine-β-
alanine) was approved by using UV-Vis, FTIR, 1
H NMR
and LC-MS analysis. The UV-Vis absorbance spectra of
histidine-β-alanine obtained in water at 25 °C is presented
in Figure 1. The results show that the maximum peaks
were appeared at 214 and 264 nm, which can be assigned
to π→π* and n→π*, respectively.<br />
FTIR (KBr) n / cm−1 3226 (NH2), 1641 (amide), 1563
(imidazol);<br />
<br />
1H NMR (300 MHz, D2O) d 2.60 (m, 2 Hs,
12H), 2.92 (dd, 1 Hs, 6H), 3.08 (dd, 1 Hs, 6H), 3.16 (m,
2 Hs, 11H), 4.40 (dd, 1 Hs, 7H), 6.89 (s, 1 Hs, 4H), 7.66
(dd, 1 Hs, 2H), 7.89 (imidazole ring).<br />
<br />
The LC-MS analysis
showed a single mass peak in [M + H]+
and [M]−
, which <br />
correspond to molecular weight for dipeptide calculated
for C9H14N4O3: 226.23; found m/z [M + H]+
: 227.000 and
m/z [M]−
: 224.800 (Figure 2).<br />
<br />
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-HRCacoQMOTg/V99FR1YuxOI/AAAAAAAAUCQ/quW3lsrgcekoaLY8tLIvxELBYYbxAXqpQCLcB/s1600/str1.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="382" src="https://2.bp.blogspot.com/-HRCacoQMOTg/V99FR1YuxOI/AAAAAAAAUCQ/quW3lsrgcekoaLY8tLIvxELBYYbxAXqpQCLcB/s640/str1.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-UuSzPV0YIQA/V99FRk0BC2I/AAAAAAAAUCM/AHr_u6lcU1wDzdRfUEs2Uy-FjXeQo9FPACLcB/s1600/str2.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="378" src="https://3.bp.blogspot.com/-UuSzPV0YIQA/V99FRk0BC2I/AAAAAAAAUCM/AHr_u6lcU1wDzdRfUEs2Uy-FjXeQo9FPACLcB/s640/str2.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-YM1jY9GF-lo/V99FRz3ND8I/AAAAAAAAUCU/tlPvqfgVDFMGvMtAGokVhIup4gsCvIwdgCLcB/s1600/str3.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="398" src="https://1.bp.blogspot.com/-YM1jY9GF-lo/V99FRz3ND8I/AAAAAAAAUCU/tlPvqfgVDFMGvMtAGokVhIup4gsCvIwdgCLcB/s640/str3.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-2igFFy9M1SY/V99FSV-jIXI/AAAAAAAAUCY/KDlqAOG6t0UoAhEaqkwmDEJXkAVXd3zNgCLcB/s1600/str4.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="368" src="https://2.bp.blogspot.com/-2igFFy9M1SY/V99FSV-jIXI/AAAAAAAAUCY/KDlqAOG6t0UoAhEaqkwmDEJXkAVXd3zNgCLcB/s640/str4.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-VaBI9vrwXRE/V99FS-DzIOI/AAAAAAAAUCc/l3Ba1-shZXoAvsrcWsLAU2xxvZV8XI2RgCLcB/s1600/str5.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="264" src="https://3.bp.blogspot.com/-VaBI9vrwXRE/V99FS-DzIOI/AAAAAAAAUCc/l3Ba1-shZXoAvsrcWsLAU2xxvZV8XI2RgCLcB/s640/str5.JPG" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-zEnArpV9ETk/V99FS7-HkNI/AAAAAAAAUCg/NYX78CTVKXIEmx1z7JwLMmJLaQTZgG-5gCLcB/s1600/str6.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="640" src="https://4.bp.blogspot.com/-zEnArpV9ETk/V99FS7-HkNI/AAAAAAAAUCg/NYX78CTVKXIEmx1z7JwLMmJLaQTZgG-5gCLcB/s640/str6.JPG" width="534" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-OrvfoKjCzuo/V99FTKQvVXI/AAAAAAAAUCk/94cLFHVOzcQmwh1KwBnWyQ-tFfNzNc5EgCLcB/s1600/str7.JPG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="440" src="https://1.bp.blogspot.com/-OrvfoKjCzuo/V99FTKQvVXI/AAAAAAAAUCk/94cLFHVOzcQmwh1KwBnWyQ-tFfNzNc5EgCLcB/s640/str7.JPG" width="640" /></a></div>
<br />
<br />
<br />
<span class="pagina" style="color: #6c8cb0; display: inline; float: right; font-family: inherit; margin: 0px; padding: 0px;"><em style="font-family: inherit; margin: 0px; padding: 0px;">J. Braz. Chem. Soc.</em> <strong style="font-family: inherit; margin: 0px; padding: 0px;">2016</strong>,<em style="font-family: inherit; margin: 0px; padding: 0px;"> 27(10)</em>, 1814-1819</span><br />
<div class="margem_artigo" style="font-family: inherit; margin: 0px 0px 0px 30px; padding: 0px;">
<h3 style="clear: both; color: #333333; font-family: inherit; font-size: 1.2em; margin: 0.2em 0px; padding: 0px;">
<a class="tituloArtigo" href="http://jbcs.sbq.org.br/audiencia_pdf.asp?aid2=4603&nomeArquivo=151251AR.pdf" style="clear: right; color: #333333; font-family: inherit; font-weight: normal; margin: 0px; padding: 0px; text-decoration: none;" target="_blank">Solid-Phase Peptide Synthesis of Dipeptide (Histidine-β-Alanine) as a Chelating Agent by Using Trityl Chloride Resin, for Removal of Al<sup style="font-family: inherit; margin: 0px; padding: 0px;">3+</sup>, Cu<sup style="font-family: inherit; margin: 0px; padding: 0px;">2+</sup>, Hg<sup style="font-family: inherit; margin: 0px; padding: 0px;">2+</sup> and Pb<sup style="font-family: inherit; margin: 0px; padding: 0px;">2+</sup>: Experimental and Theoretical Study</a></h3>
<span class="descricao" style="font-family: inherit; font-size: 1em; margin: 0px; padding: 0px;"></span><br />
<div class="autores" style="color: #6c6c6c; font-family: inherit; font-size: 0.9em; margin-bottom: 1em; margin-left: 27px; margin-top: 1em; padding: 0px; text-align: justify;">
Rahmatollah Rahimi; Maryam Khosravi; Mohammd H. H. Tehrani; Mahboubeh Rabbani; Ebrahim Safavi<br />
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-GpwlmYB9Olc/V99GVVfXpTI/AAAAAAAAUCs/JOPkYVjX_psCyNfpA5DVKiTDg1o4dnQggCLcB/s1600/str1.JPG" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="188" src="https://2.bp.blogspot.com/-GpwlmYB9Olc/V99GVVfXpTI/AAAAAAAAUCs/JOPkYVjX_psCyNfpA5DVKiTDg1o4dnQggCLcB/s640/str1.JPG" width="640" /></a></div>
<br />
<br />
<br /></div>
<span style="background-color: #e8e8e8; font-family: "verdana" , "arial" , "helvetica" , sans-serif; font-size: 10px;">Rahimi R, Khosravi M, Tehrani MHH, Rabbani M, Safavi E. Solid-Phase Peptide Synthesis of Dipeptide (Histidine-β-Alanine) as a Chelating Agent by Using Trityl Chloride Resin, for Removal of Al</span><sup style="font-family: Verdana, Arial, Helvetica, sans-serif; margin: 0px; padding: 0px;">3+</sup><span style="background-color: #e8e8e8; font-family: "verdana" , "arial" , "helvetica" , sans-serif; font-size: 10px;">, Cu</span><sup style="font-family: Verdana, Arial, Helvetica, sans-serif; margin: 0px; padding: 0px;">2+</sup><span style="background-color: #e8e8e8; font-family: "verdana" , "arial" , "helvetica" , sans-serif; font-size: 10px;">, Hg</span><sup style="font-family: Verdana, Arial, Helvetica, sans-serif; margin: 0px; padding: 0px;">2+</sup><span style="background-color: #e8e8e8; font-family: "verdana" , "arial" , "helvetica" , sans-serif; font-size: 10px;"> and Pb</span><sup style="font-family: Verdana, Arial, Helvetica, sans-serif; margin: 0px; padding: 0px;">2+</sup><span style="background-color: #e8e8e8; font-family: "verdana" , "arial" , "helvetica" , sans-serif; font-size: 10px;">: Experimental and Theoretical Study. </span><em style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 10px; margin: 0px; padding: 0px;">J. Braz. Chem. Soc</em><span style="background-color: #e8e8e8; font-family: "verdana" , "arial" , "helvetica" , sans-serif; font-size: 10px;">. 2016;27(10):1814-1819</span></div>
<div class="margem_artigo" style="margin: 0px 0px 0px 30px; padding: 0px;">
<span style="font-family: "verdana" , "arial" , "helvetica" , sans-serif;"><span style="font-size: 10px;"><br /></span></span>
<br />
<div class="imgArtigo" style="font-family: inherit; margin: 0px; padding: 0px 10px; text-align: center;">
<img class="lazy" src="http://jbcs.sbq.org.br/imageBank/images/151251AR-GA.jpg" data-original="imageBank/images/151251AR-GA.jpg" style="display: inline; font-family: inherit; margin: 0px; max-width: 650px; padding: 0px;" /><br />
<div style="color: #333333; font-family: inherit; font-size: 0.9em; margin-bottom: 1em; margin-top: 1em; padding: 0px; text-align: justify;">
Solid-phase peptide synthesis of dipeptide (histidine-β-alanine) as a chelating agent examined. Trityl chloride resin was used as a carrier.</div>
</div>
<h4 style="font-family: inherit; margin: 0px; padding: 0px;">
<a href="http://dx.doi.org/10.5935/0103-5053.20160064" style="color: #005c9d; font-family: inherit; font-size: 0.9em; margin: 0px; padding: 0px;" target="_blank">http://dx.doi.org/10.5935/0103-5053.20160064</a></h4>
<div class="listaBotoes" style="border-bottom: 1px solid rgb(203, 203, 203); font-family: inherit; line-height: 15px; margin: 15px 0px 5px 5px; padding: 0px 0px 25px; text-align: right;">
<div class="published" style="background-color: white; color: #6c6c6c; font-family: Tahoma, Geneva, sans-serif; font-size: 12px; margin: 0px 0px -19px; padding: 0px; text-align: left;">
Published online: March 1, 2016</div>
<div>
<br /></div>
<a href="https://www.facebook.com/dialog/feed?app_id=192102654459402&display=popup&link=http://jbcs.sbq.org.br/audiencia_pdf.asp?aid2=4603&nomeArquivo=151251AR.pdf&name=Solid-Phase%20Peptide%20Synthesis%20of%20Dipeptide%20(Histidine-%26%23946%3B-Alanine)%20as%20a%20Chelating%20Agent%20by%20Using%20Trityl%20Chloride%20Resin,%20for%20Removal%20of%20Al3+,%20Cu2+,%20Hg2+%20and%20Pb2+:%20Experimental%20and%20Theoretical%20Study&picture=http://jbcs.sbq.org.br/imageBank/images/151251AR-GA.jpg&redirect_uri=http://jbcs.sbq.org.br/" style="background-color: white; color: #333333; font-family: Tahoma, Geneva, sans-serif; font-size: 12px; margin: 0px; padding: 0px; text-decoration: none;" target="_blank"></a></div>
</div>
*e-mail: rahimi_rah@iust.ac.ir<br />
<br />
<br />
<img alt="Department of Chemistry" height="85" src="http://www.iust.ac.ir/files/chemistry/site/tmpl_sanat7_banner_en.jpg" width="640" /><br />
<br />
<table align="center" border="0" cellpadding="0" cellspacing="0" class="tbl" dir="ltr" style="background-color: #fbfbf9; border-collapse: collapse; border: 2px solid rgb(95, 125, 151); font-family: Tahoma, Helvetica, sans-serif; width: 99%px;"><tbody style="font-size: 11px; line-height: 2.2; margin-bottom: 0px; margin-top: 0px; text-align: justify;">
<tr align="justify"><td class="tbld_even" style="background-color: #f5f5f7; border: 1px solid rgb(95, 125, 151); padding: 0.3em;"><div style="font-size: 12px;">
Dr. Rahmatollah Rahimi</div>
<table align="center" border="0" cellpadding="0" cellspacing="0" class="tbl" dir="ltr" style="border-collapse: collapse; border: 2px solid rgb(95, 125, 151); width: 99%px;"><tbody style="font-size: 11px; line-height: 2.2; margin-bottom: 0px; margin-top: 0px; text-align: justify;">
<tr align="justify"><td class="tbld_odd" style="background-color: #cdd7e1; border: 1px solid rgb(95, 125, 151); padding: 0.3em;"><div style="font-size: 12px;">
Professor, Inorganic Chemistry Division</div>
<div style="font-size: 12px;">
E-mail address: <a href="mailto:Rahimi_Rah@iust.ac.ir" style="border: 0px; color: #0a5dc3; margin: 0px; padding: 0px; text-decoration: none;">Rahimi_Rah@iust.ac.ir</a></div>
<div style="font-size: 12px;">
Office Tele: 77240290, 77240-50(2718)</div>
<div style="font-size: 12px;">
Fax: 77491204</div>
</td><td class="tbld_odd" style="background-color: #cdd7e1; border: 1px solid rgb(95, 125, 151); padding: 0.3em;"><div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
<img alt="AWT IMAGE" border="0" complete="true" hspace="0" src="http://www.iust.ac.ir/files/chemistry/pages/dr_rahimi.gif" style="border: 0px; margin: 0px; padding: 0px;" /></div>
</td></tr>
</tbody></table>
<div style="font-size: 12px;">
<br /></div>
</td></tr>
<tr align="justify"><td class="tbld_even" style="background-color: #f5f5f7; border: 1px solid rgb(95, 125, 151); padding: 0.3em;"><div style="font-size: 12px;">
Academic Degrees:</div>
<div style="font-size: 12px;">
Bachelor of Science: Chemistry, Howard University, USA, 1983</div>
<div style="font-size: 12px;">
Master of Science: Physical chemistry, Howard University, USA, 1987</div>
<div style="font-size: 12px;">
Ph. D.: Inorganic Chemistry, Howard University, USA, 1991</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
Active Research fields:</div>
<div style="font-size: 12px;">
- Synthesis and characterization of porphyrins and metalloporphyrins and Investigation of their applications.</div>
<div style="font-size: 12px;">
- Photocatalysis process</div>
<div style="font-size: 12px;">
- Preparation and characterization of solar cells</div>
<div style="font-size: 12px;">
- Invironmental projects</div>
<div style="font-size: 12px;">
- Bioinorganic chemistry</div>
</td></tr>
<tr align="justify"><td class="tbld_odd" style="background-color: #cdd7e1; border: 1px solid rgb(95, 125, 151); padding: 0.3em;"><div style="font-size: 12px;">
Teaching Experiences:</div>
<div style="font-size: 12px;">
A) Teaching Courses at undergraduate level:</div>
<div style="font-size: 12px;">
-General chemistry</div>
<div style="font-size: 12px;">
-Inorganic Chemistry</div>
<div style="font-size: 12px;">
-Physical chemistry</div>
<div style="font-size: 12px;">
-Physical chemistry laboratory</div>
<div style="font-size: 12px;">
-General Chemistry laboratory</div>
<div style="font-size: 12px;">
-Chemistry science literature</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
B) Teaching Courses at graduate level (MS):</div>
<div style="font-size: 12px;">
-The professional language for Chemistry</div>
<div style="font-size: 12px;">
-Inorganic kinetics and Thermodynamics</div>
<div style="font-size: 12px;">
-Physical Inorganic Chemistry</div>
<div style="font-size: 12px;">
-Research method</div>
<div style="font-size: 12px;">
-Advanced Inorganic Chemistry</div>
<div style="font-size: 12px;">
-Bio Inorganic Chemistry</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
C) Teaching Courses at graduate level (PhD):</div>
<div style="font-size: 12px;">
-Advanced Bio Inorganic Chemistry</div>
<div style="font-size: 12px;">
-Structures and bonds of inorganic components</div>
<div style="font-size: 12px;">
- Organometallic Chemistry</div>
<div style="font-size: 12px;">
<a href="http://www.iust.ac.ir/files/chemistry/ISI/rahimi/2402_coordchemisomers.ppsx" style="border: 0px; color: #0a5dc3; margin: 0px; padding: 0px; text-decoration: none;">structural inorganic chemistry</a></div>
</td></tr>
<tr align="justify"><td class="tbld_even" style="background-color: #f5f5f7; border: 1px solid rgb(95, 125, 151); padding: 0.3em;"><div style="font-size: 12px;">
Research activities:</div>
<div style="font-size: 12px;">
A) Scientific Research articles :</div>
<div style="font-size: 12px;">
More than 175 Articles Published at Conferences and Journals</div>
<div style="font-size: 12px;">
<br /></div>
</td></tr>
<tr align="justify"><td class="tbld_odd" style="background-color: #cdd7e1; border: 1px solid rgb(95, 125, 151); padding: 0.3em;"><div style="font-size: 12px;">
Patent:</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
1. “Application of LED lamps for treatment and disinfection of wastewaters using nanophotocatalysts” Rahmatollah Rahimi, Javad Shokraian, Mahboobeh Rabbani, 1393</div>
<div style="font-size: 12px;">
</div>
<div style="font-size: 12px;">
2. “Synthesis of ZnO Nanorods in low temperature via Coprecipitation Method”<span style="border: 0px; font-weight: 700; margin: 0px; padding: 0px;"> </span>Rahmatollah Rahimi, Marzieh Yaghoubi Berijani, Solmaz Zargari, 1393</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
3. “Synthesis of BiVO<sub style="border: 0px; margin: 0px; padding: 0px;">4</sub> photocatalyst with two monoclinic and tetragonal phases, active in visible and ultraviolet region”,<span style="border: 0px; font-weight: 700; margin: 0px; padding: 0px;"> </span>Rahmatollah Rahimi, Marzieh Yaghoubi Berijani, Solmaz Zargari, 1393</div>
<div style="font-size: 12px;">
<span style="border: 0px; font-weight: 700; margin: 0px; padding: 0px;"> </span> <span style="border: 0px; font-weight: 700; margin: 0px; padding: 0px;"> </span></div>
<div style="font-size: 12px;">
4. “Synthesis of polypyrrole-iron oxide functionalized with porphyrin as an efficient sorbent of industrial pollutions”, Rahmatollah Rahimi, Meisam Asadi Davati, Solmaz Zargari, 1392</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
5. “ Synthesis of Titanium dioxide (TiO<sub style="border: 0px; margin: 0px; padding: 0px;">2</sub>)-Vanadium phosphorous nanocomposite oxidized with silver (Ag-VPO) as a catalyst (Ag-VPO/TiO<sub style="border: 0px; margin: 0px; padding: 0px;">2</sub>) and is organic pollution degradation under visible light illumination”, Rahmatollah Rahimi, Masoumeh Mahjoub Moghaddas, Solmaz Zargari, 1391</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
6. “ Synthesis of SbVO<sub style="border: 0px; margin: 0px; padding: 0px;">4</sub>-TiO<sub style="border: 0px; margin: 0px; padding: 0px;">2</sub> nanocomposite as a catalysts and its investigation in degradation of organic pollutions under visible light irradiation”, Rahmatollah Rahimi, Masoumeh Mahjoub Moghaddas, Solmaz Zargari, 1391</div>
<div style="font-size: 12px;">
</div>
<div style="font-size: 12px;">
7. “Synthesis of Titanium dioxide-Bismut vanadat (BiVO<sub style="border: 0px; margin: 0px; padding: 0px;">4</sub>-TiO<sub style="border: 0px; margin: 0px; padding: 0px;">2</sub>) sensitized with porphyrin (TCPP) and its photocatalytic application under visible light irradiation”, Rahmatollah Rahimi, Masoumeh Mahjoub Moghaddas, Solmaz Zargari, 1391</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
8. “Preparation ofV-TiO<sub style="border: 0px; margin: 0px; padding: 0px;">2</sub>-TCPP and its concurrent application in removal anddegradation of industrial pollutants”, Rahmatollah Rahimi, Masoumeh MahjoubMoghaddas, Solmaz Zargari, 1391</div>
<div style="font-size: 12px;">
</div>
<div style="font-size: 12px;">
9. “Preparation of Vdoped TiO<sub style="border: 0px; margin: 0px; padding: 0px;">2</sub> mesoporous and sensitized with porphyrin over SBA-15substrate”, Ahmad Najafian, Masoumeh Mahjoub Moghaddas, Rahmatollah Rahimi, 1391</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
10. “Preparation ofporphyrin on SBA-15 catalysts”, Mehdi Deilam Kamar, Ahmad najafian, RahmatollahRahimi, 1391.</div>
<div style="font-size: 12px;">
<br /></div>
<div style="font-size: 12px;">
11. “Nanoporous TiO<sub style="border: 0px; margin: 0px; padding: 0px;">2</sub>solar cell sensitized with tetra(4-carboxyphenyl)porphyrin”, RahmatollahRahimi, Pegah Tvakoli fard, 2010</div>
</td></tr>
</tbody></table>
<br />
<br />
<img alt="Image result for Rahmatollah Rahimi" src="https://i.ytimg.com/vi/EoKDcuF_zL0/hqdefault.jpg" /><br />
<br />
<br />
<br />
<br />
///////////</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com3tag:blogger.com,1999:blog-81273127788638440.post-75154133123515493012016-08-15T11:22:00.001+05:302016-08-15T11:22:20.892+05:30High Throughput Enzymatic Enantiomeric Excess: Quick-ee<div dir="ltr" style="text-align: left;" trbidi="on">
<img alt="" class="" data-mce-src="http://jbcs.sbq.org.br/imageBank/images/jbcs26-2-cover.jpg" height="560" src="http://jbcs.sbq.org.br/imageBank/images/jbcs26-2-cover.jpg" width="640" />.<br />
<div class="imgArtigo">
High
throughput screening techniques (HTS) are fast and efficient
alternatives to evaluate enzymatic activities. Here, this technique is
applied to obtain enantiomeric excess and conversions values with chiral
fluorogenic probes and a non fluorogenic competitor, which was named
Quick-ee. The fluorescent signal reveals of the enantioselectivity of
the enzyme. Details are presented in the Article <b>High Throughput Enzymatic Enantiomeric Excess: Quick-<i>ee</i></b> by <i>Maria L. S. de O. Lima, Caroline C. da S. Gonçalves, Juliana C. Barreiro, Quezia Bezerra Cass and Anita Jocelyne Marsaioli</i> on page 319.</div>
<h4>
<a data-mce-href="http://dx.doi.org/10.5935/0103-5053.20140282" href="http://dx.doi.org/10.5935/0103-5053.20140282" target="_blank">http://dx.doi.org/10.5935/0103-5053.20140282</a></h4>
<img alt="" class="" data-mce-src="http://jbcs.sbq.org.br/imageBank/images/140670AR-GA.jpg" height="270" src="http://jbcs.sbq.org.br/imageBank/images/140670AR-GA.jpg" width="640" /><br />
<div align="center" class="cover">
Cover Article</div>
<div class="artigosLista">
<span class="pagina"><em>J. Braz. Chem. Soc.</em> <strong>2015</strong>, <em>26(2)</em>, 319-324</span><br />
<h3>
<a class="tituloArtigo" data-mce-href="http://jbcs.sbq.org.br/audiencia_pdf.asp?aid2=4151&nomeArquivo=v26n2a14.pdf" href="http://jbcs.sbq.org.br/audiencia_pdf.asp?aid2=4151&nomeArquivo=v26n2a14.pdf" target="_blank">High Throughput Enzymatic Enantiomeric Excess: Quick-<i>ee</i></a></h3>
<div class="autores">
Maria L. S. O. Lima; Caroline C. S. Gonçalves; Juliana C. Barreiro; Quezia B. Cass; Anita J. Marsaioli</div>
</div>
Lima MLSO, Gonçalves CCS, Barreiro JC, Cass QB, Marsaioli AJ. High Throughput Enzymatic Enantiomeric Excess: Quick-<i>ee</i>.<em>J. Braz. Chem. Soc</em>. 2015;26(2):319-324<br />
/////////////High Throughput, Enzymatic, Enantiomeric Excess, Quick-<i>ee</i><br />
http://jbcs.sbq.org.br/imagebank/pdf/v26n2a14.pdf<br />
http://jbcs.sbq.org.br/imagebank/pdf/v26n2a14-Sup01.pdf</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com0tag:blogger.com,1999:blog-81273127788638440.post-41795590195635054912016-07-29T13:40:00.001+05:302016-07-29T13:40:15.785+05:30Ring-locking enables selective anhydrosugar synthesis from carbohydrate pyrolysis<div dir="ltr" style="text-align: left;" trbidi="on">
<div style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px; line-height: 24px;">
<img align="center" alt="" class="" data-mce-src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6GC01600F" height="326" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6GC01600F" style="height: auto; max-width: 100%;" width="868" /></div>
<div style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px; line-height: 24px;">
<br /></div>
<h4 class="itemtitle" style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px; line-height: 24px;">
<a data-mce-href="http://feeds.rsc.org/~r/rss/GC/~3/6yBdvR1LLGs/C6GC01600F" href="http://feeds.rsc.org/~r/rss/GC/~3/6yBdvR1LLGs/C6GC01600F">Ring-locking enables selective anhydrosugar synthesis from carbohydrate pyrolysis</a></h4>
<div class="itemcontent" style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px; line-height: 24px;">
<div>
<i><b>Green Chem.</b></i>, 2016, Advance Article<br /><b>DOI</b>: 10.1039/C6GC01600F, Paper</div>
<div>
Li Chen, Jinmo Zhao, Sivaram Pradhan, Bruce E. Brinson, Gustavo E. Scuseria, Z. Conrad Zhang, Michael S. Wong<br />The nonselective nature of glucose pyrolysis chemistry can be controlled by preventing the sugar ring from opening and fragmenting.</div>
<div>
<div class="article_chemsoc_txt_s13">
<h2 class="alpH1">
Ring-locking enables selective anhydrosugar synthesis from carbohydrate pyrolysis</h2>
</div>
<div class="peptide_wrap_s10_left">
<div class="peptide_middle">
<div>
<span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3ALi%20Chen" href="http://pubs.rsc.org/en/results?searchtext=Author%3ALi%20Chen">Li Chen</a>,<sup>a</sup> </span> <span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AJinmo%20Zhao" href="http://pubs.rsc.org/en/results?searchtext=Author%3AJinmo%20Zhao">Jinmo Zhao</a>,<sup>b</sup> </span> <span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3ASivaram%20Pradhan" href="http://pubs.rsc.org/en/results?searchtext=Author%3ASivaram%20Pradhan">Sivaram Pradhan</a>,<sup>a</sup> </span> <span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3ABruce%20E.%20Brinson" href="http://pubs.rsc.org/en/results?searchtext=Author%3ABruce%20E.%20Brinson">Bruce E. Brinson</a>,<sup>b</sup> </span><span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AGustavo%20E.%20Scuseria" href="http://pubs.rsc.org/en/results?searchtext=Author%3AGustavo%20E.%20Scuseria">Gustavo E. Scuseria</a>,<sup>b</sup> </span> <span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AZ.%20Conrad%20Zhang" href="http://pubs.rsc.org/en/results?searchtext=Author%3AZ.%20Conrad%20Zhang">Z. Conrad Zhang</a>*<sup>c</sup> and </span><span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AMichael%20S.%20Wong" href="http://pubs.rsc.org/en/results?searchtext=Author%3AMichael%20S.%20Wong">Michael S. Wong</a>*<sup>a</sup><sup>b</sup><sup>d</sup><sup>e</sup> </span></div>
<div class="show_affiliation_section" id="aff_info">
<div class="show_aff_content">
<div class="show_affiliation">
*Corresponding authors</div>
</div>
<div class="show_aff_content">
<div class="show_affiliation">
<sup class="affiliation_sup">a</sup>Department of Chemical and Biomolecular Engineering, Rice University, Houston, USA<br /><b>E-mail: </b><a data-mce-href="mailto:mswong@rice.edu" href="mailto:mswong@rice.edu" title="mswong@rice.edu">mswong@rice.edu</a></div>
</div>
<div class="show_aff_content">
<div class="show_affiliation">
<sup class="affiliation_sup">b</sup>Department of Chemistry, Rice University, Houston, USA</div>
</div>
<div class="show_aff_content">
<div class="show_affiliation">
<sup class="affiliation_sup">c</sup>Dalian National Laboratory of Clean Energy, Dalian Institute of Chemical Physics, Dalian, China<br /><b>E-mail: </b><a data-mce-href="mailto:zczhang@dicp.ac.cn" href="mailto:zczhang@dicp.ac.cn" title="zczhang@dicp.ac.cn">zczhang@dicp.ac.cn</a></div>
</div>
<div class="show_aff_content">
<div class="show_affiliation">
<sup class="affiliation_sup">d</sup>Department of Civil and Environmental Engineering, Rice University, Houston, USA</div>
</div>
<div class="show_aff_content">
<div class="show_affiliation">
<sup class="affiliation_sup">e</sup>Department of Materials Science and NanoEngineering, Rice University, Houston, USA</div>
</div>
</div>
<div class="red_txt_s4">
<i><strong>Green Chem.</strong></i>, 2016, Advance Article</div>
<span class="DOILink"><strong>DOI: </strong>10.1039/C6GC01600F</span></div>
<div class="peptide_middle">
see ....................<a data-mce-href="http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01600F?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract" href="http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01600F?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract">http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01600F?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract</a></div>
</div>
<div class="peptide_middle">
The selective production of platform chemicals from thermal conversion of biomass-derived carbohydrates is challenging. As precursors to natural products and drug molecules, anhydrosugars are difficult to synthesize from simple carbohydrates in large quantities without side products, due to various competing pathways during pyrolysis. Here we demonstrate that the nonselective chemistry of carbohydrate pyrolysis is substantially improved by alkoxy or phenoxy substitution at the anomeric carbon of glucose prior to thermal treatment. Through this ring-locking step, we found that the selectivity to 1,6-anhydro-β-<small>D</small>-glucopyranose (levoglucosan, LGA) increased from 2% to greater than 90% after fast pyrolysis of the resulting sugar at 600 °C. DFT analysis indicated that LGA formation becomes the dominant reaction pathway when the substituent group inhibits the pyranose ring from opening and fragmenting into non-anhydrosugar products. LGA forms selectively when the activation barrier for ring-opening is significantly increased over that for 1,6-elimination, with both barriers affected by the substituent type and anomeric position. These findings introduce the ring-locking concept to sugar pyrolysis chemistry and suggest a chemical-thermal treatment approach for upgrading simple and complex carbohydrates.</div>
</div>
</div>
<div style="color: #333333; font-family: Georgia, "Times New Roman", "Bitstream Charter", Times, serif; font-size: 16px; line-height: 24px;">
<a data-mce-href="http://www.rsc.org/suppdata/c6/gc/c6gc01600f/c6gc01600f1.pdf" href="http://www.rsc.org/suppdata/c6/gc/c6gc01600f/c6gc01600f1.pdf">////</a>////Ring-locking , selective anhydrosugar, carbohydrate pyrolysis, synthesis</div>
</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com1tag:blogger.com,1999:blog-81273127788638440.post-67896118969572564072016-07-19T09:55:00.001+05:302016-07-19T09:55:07.345+05:302-chloro-3-(3-chloro-5-iodophenoxy)-4-(trifluoromethyl)pyridine<div dir="ltr" style="text-align: left;" trbidi="on">
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-FgXcxMSooyk/V42ocV671kI/AAAAAAAATCA/OiFcD07gqMk-SpmNJj2Y9kcnaAXjrDxdgCLcB/s1600/STR1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://1.bp.blogspot.com/-FgXcxMSooyk/V42ocV671kI/AAAAAAAATCA/OiFcD07gqMk-SpmNJj2Y9kcnaAXjrDxdgCLcB/s1600/STR1.jpg" /></a></div>
<br />
<br />
2-chloro-3-(3-chloro-5-iodophenoxy)-4-(trifluoromethyl)pyridine<br />
<br />
<br />
1H NMR (400 MHz, DMSO-d6) δ 8.65 (d, J = 4.9 Hz, 1H), 7.95 (t, J = 4.5 Hz, 1H), 7.60 (dd, J = 1.3, 2.9Hz, 1H), 7.38 (br. s., 1H), 7.29 - 7.15 (m, 1H)<br />
<br />
<br />
13C NMR (101 MHz, DMSO-d6) δ 157.10, 148.02, 145.37, 142.46 (q, JC-F = 2.0 Hz), 135.00, 132.82 (q,JC-F = 33.2 Hz), 131.69, 122.91, 121.59 (q, JC-F = 4.0 Hz), 121.34 (q, JC-F = 273.7 Hz), 115.47, 95.72<br />
<br />
19F NMR (377 MHz, DMSO-d6) δ -61.96 (s, 1F)<br />
mp 71.69-79.27 °C<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-NIxvaT3qEu4/V42nudZtSrI/AAAAAAAATBw/O76KJHd8s5kLRzKxBRPw92k0WtDFPvoLwCLcB/s1600/STR1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="376" src="https://4.bp.blogspot.com/-NIxvaT3qEu4/V42nudZtSrI/AAAAAAAATBw/O76KJHd8s5kLRzKxBRPw92k0WtDFPvoLwCLcB/s640/STR1.jpg" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-faf2hDdgj6g/V42n6SgM7PI/AAAAAAAATB0/1KgWjU3meaQHlu6K3xNcq7UP7JpYjp8tgCLcB/s1600/STR1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="410" src="https://3.bp.blogspot.com/-faf2hDdgj6g/V42n6SgM7PI/AAAAAAAATB0/1KgWjU3meaQHlu6K3xNcq7UP7JpYjp8tgCLcB/s640/STR1.jpg" width="640" /></a></div>
<br />
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-19H7VgpWWJA/V42oH9AaeYI/AAAAAAAATB4/qwnDSUZ-xeQOJxQKvCldMqEqv717dW8NACLcB/s1600/STR1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="396" src="https://1.bp.blogspot.com/-19H7VgpWWJA/V42oH9AaeYI/AAAAAAAATB4/qwnDSUZ-xeQOJxQKvCldMqEqv717dW8NACLcB/s640/STR1.jpg" width="640" /></a></div>
<br />
<a href="http://pubs.acs.org/doi/suppl/10.1021/acs.oprd.6b00163">////////</a>///////</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com1tag:blogger.com,1999:blog-81273127788638440.post-15220644850999465992016-07-11T12:32:00.001+05:302016-07-11T12:32:50.329+05:30Nickel-Catalyzed Decarbonylative Suzuki–Miyaura Coupling of Amides To Generate Biaryls<div dir="ltr" style="text-align: left;" trbidi="on">
<div style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
<a class="figZoom" data-mce-href="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/image_m/anie201601914-toc-0001-m.png?v=1&s=c79689618d93ef7df070125ecea6b4f2506415d3" href="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/image_m/anie201601914-toc-0001-m.png?v=1&s=c79689618d93ef7df070125ecea6b4f2506415d3" title="Link to full-size graphical abstract"><img alt="Thumbnail image of graphical abstract" class="" data-mce-src="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/image_n/anie201601914-toc-0001.png?v=1&s=558c522081ef9dd23ee535823649c069f0286f84" src="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/image_n/anie201601914-toc-0001.png?v=1&s=558c522081ef9dd23ee535823649c069f0286f84" height="160" style="height: auto; max-width: 100%;" title="Thumbnail image of graphical abstract" width="927" /></a><br />
<br />
<br />
<br />
<br /></div>
<div style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
<img alt="" data-mce-src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/oprdfk/0/oprdfk.ahead-of-print/acs.oprd.6b00218/20160707/images/medium/op-2016-00218u_0002.gif" src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/oprdfk/0/oprdfk.ahead-of-print/acs.oprd.6b00218/20160707/images/medium/op-2016-00218u_0002.gif" style="height: auto; max-width: 100%;" /><br />
<br />
<br />
<br /></div>
<div class="NLM_p last" style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
Shi et al. have reported a nickel-catalyzed decarbonylative Suzuki–Miyaura reaction which uses an <i>N</i>-aroylpiperidine-2,6-dione as the coupling partner for the boronic acid ( <cite>Angew. Chem., Int. Ed.</cite> 2016<span class="NLM_x">, </span><em>55</em><span class="NLM_x">, </span>6959−6963).</div>
<div class="NLM_p last" style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
</div>
<div class="NLM_p last" style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
The method is attractive from the point of view of the stability of <i>N</i>-aroylpyrrolidine-2,5-diones toward storage and manipulation and the flexibility they add to the chemist’s toolbox, given their preparation from a different group of precursors to aryl halides or triflates.</div>
<div class="NLM_p last" style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
</div>
<div class="NLM_p last" style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
Notably, the reaction uses an air-stable and inexpensive nickel catalyst, and the reactions tolerate the presence of water. While a standard reaction temperature of 150 °C is quoted, the use of temperatures as low as 80 °C also seem to be possible. Coupling efficiency is reported to be adversely affected when the aromatic rings of both of the coupling partners bear electron-donating substituents.</div>
<div class="NLM_p last" style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
</div>
<div class="NLM_p last" style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
Ortho substituents on the aromatic rings seem to be beneficial as they facilitate decarbonylation as part of the cross-coupling. Oxidative addition into the N–C(aroyl) bond of the amide is proposed as initiating the catalytic cycle and is possible on account of a reduction in the resonance stabilization of the <i>N</i>-aroyl functionality versus a conventional aromatic amide.</div>
<h4 style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
Suzuki–Miyaura Coupling<input id="option1" name="doi" type="checkbox" value="10.1002/anie.201601914" /></h4>
<div class="citation tocArticle" style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
<a data-mce-href="http://onlinelibrary.wiley.com/doi/10.1002/anie.201601914/full" href="http://onlinelibrary.wiley.com/doi/10.1002/anie.201601914/full">Synthesis of Biaryls through Nickel-Catalyzed Suzuki–Miyaura Coupling of Amides by Carbon–Nitrogen Bond Cleavage (pages 6959–6963)</a>Shicheng Shi, Guangrong Meng and Prof. Dr. Michal Szostak<br />
Version of Record online: 21 APR 2016 | DOI: 10.1002/anie.201601914<br />
<div class="articleAbstract">
<a class="figZoom" data-mce-href="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/image_m/anie201601914-toc-0001-m.png?v=1&s=c79689618d93ef7df070125ecea6b4f2506415d3" href="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/image_m/anie201601914-toc-0001-m.png?v=1&s=c79689618d93ef7df070125ecea6b4f2506415d3" title="Link to full-size graphical abstract"><img alt="Thumbnail image of graphical abstract" class="" data-mce-src="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/image_n/anie201601914-toc-0001.png?v=1&s=558c522081ef9dd23ee535823649c069f0286f84" src="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/image_n/anie201601914-toc-0001.png?v=1&s=558c522081ef9dd23ee535823649c069f0286f84" height="126" style="height: auto; max-width: 100%;" title="Thumbnail image of graphical abstract" width="730" /></a><br />
<div class="para">
<b>Breaking and making</b>: The first nickel-catalyzed Suzuki–Miyaura coupling of amides for the synthesis of biaryl compounds through N−C amide bond cleavage is reported. The reaction tolerates a wide range of sensitive and electronically diverse substituents on both coupling partners.<br />
<a data-mce-href="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-39.jpg" href="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-39.jpg" rel="attachment wp-att-7485"><img alt="STR1" class="alignnone wp-image-7485" data-mce-src="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-39.jpg" src="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-39.jpg" height="599" style="height: auto; max-width: 100%;" width="927" /></a></div>
<a data-mce-href="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-38.jpg" href="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-38.jpg" rel="attachment wp-att-7484"><img alt="STR1" class="alignnone wp-image-7484" data-mce-src="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-38.jpg" src="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-38.jpg" height="546" style="height: auto; max-width: 100%;" width="876" /></a><br />
1H NMR (500 MHz, CDCl3) δ 7.70 (s, 4 H), 7.61 (d, J = 7.3 Hz, 2 H), 7.48 (t, J = 7.6 Hz, 2 H), 7.42 (t, J = 7.3 Hz, 1 H).<br />
<br data-mce-bogus="1" />
<a data-mce-href="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-37.jpg" href="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-37.jpg" rel="attachment wp-att-7483"><img alt="STR1" class="alignnone size-full wp-image-7483" data-mce-src="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-37.jpg" src="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-37.jpg" height="431" style="height: auto; max-width: 100%;" width="681" /></a><br />
13C NMR (125 MHz, CDCl3) δ 144.87, 139.92, 129.48 (q, J F = 32.5 Hz), 129.13, 128.32, 127.56, 127.42, 125.83 (q, J F = 3.8 Hz), 124.46 (q, J F = 270.0 Hz).</div>
</div>
<div style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
<br data-mce-bogus="1" /></div>
<div class="citation tocArticle" style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
<div class="articleAbstract">
<a data-mce-href="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-36.jpg" href="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-36.jpg" rel="attachment wp-att-7482"><img alt="STR1" class="alignnone size-full wp-image-7482" data-mce-src="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-36.jpg" src="http://www.allfordrugs.com/wp-content/uploads/2016/07/STR1-36.jpg" height="469" style="height: auto; max-width: 100%;" width="668" /></a><br />
19F NMR (471 MHz, CDCl3) δ -62.39.<br />
<br />
<br />
<br />
<table cellpadding="0" style="color: #353535; font-family: sans-serif; line-height: 17.6px;"><tbody>
<tr><td width="220"><img align="left" alt="Szostak_Photo" src="http://chemistry.rutgers.edu/szostak/szostak_2014.jpg" /></td><td><b>Michal Szostak</b>email: <a href="mailto:michal.szostak@rutgers.edu" style="color: #ae0525;">michal.szostak@rutgers.edu</a><br />
office: Olson 204<br />
<ul class="article-header__authors-item-details" style="background: 0px 0px rgb(255, 255, 255); border: 0px; color: #333333; font-family: "open sans", arial, helvetica, "lucida sans unicode", sans-serif; font-size: 10.005px; line-height: 14.007px; list-style: none; margin: 0px 0px 1.5em; outline: 0px; padding: 0px; vertical-align: baseline;">
<li style="background: 0px 0px; border: 0px; font-size: 1.3em; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><span class="article-header__authors-item-label" style="background: 0px 0px; border: 0px; font-size: 13.0065px; font-weight: 700; margin: 0px 1.077em 0px 0px; outline: 0px; padding: 0px; vertical-align: baseline;">E-mail address:</span><a class="article-header__authors-item-email" href="mailto:michal.szostak@rutgers.edu" style="background: 0px 0px; color: #2f7bae; cursor: pointer; margin: 0px; padding: 0px; vertical-align: baseline;" title="Link to email address">michal.szostak@rutgers.edu</a></li>
<li style="background: 0px 0px; border: 0px; font-size: 1.3em; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><span class="article-header__authors-item-label icon icon__orchid" style="background: url("about:blank") -60px -129px no-repeat; border: 0px; display: inline-block; font-size: 13.0065px; font-weight: 700; height: 16px; margin: 2px 1.077em 0px 0px; outline: 0px; padding: 0px; text-indent: -999em; vertical-align: baseline; width: 16px;">ORCID:</span><a class="article-header__authors-item-link" href="http://orcid.org/0000-0002-9650-9690" style="background: 0px 0px; color: #2f7bae; cursor: pointer; margin: 0px; padding: 0px; text-decoration: none; vertical-align: baseline;">orcid.org/0000-0002-9650-9690</a></li>
</ul>
<ol class="article-header__authors-item-aff-addr" style="background: 0px 0px rgb(255, 255, 255); border: 0px; color: #333333; font-family: "open sans", arial, helvetica, "lucida sans unicode", sans-serif; font-size: 10.005px; line-height: 14.007px; list-style: none; margin: 0px; outline: 0px; padding: 0px 0.8em 1.5em; vertical-align: baseline;">
<li style="background: 0px 0px; border: 0px; font-size: 1.3em; margin: 0px 0px 0.5em; outline: 0px; overflow: hidden; padding: 0px; vertical-align: baseline;">Department of Chemistry, Rutgers University, Newark, NJ, USA</li>
</ol>
</td></tr>
</tbody></table>
<h3 style="color: black; font-family: sans-serif;">
<img alt="CHEM_BANNER" src="http://chemistry.rutgers.edu/styles/FASN3_banner_top.png" /></h3>
<h3 style="color: black; font-family: sans-serif;">
<a href="https://www.blogger.com/null" name="Research_Interests"></a>Research Interests</h3>
<span style="background-color: white; color: #353535; font-family: sans-serif; font-size: small; line-height: 17.6px;">The central theme of our research is synthetic organic and organometallic chemistry with a focus on the development of new synthetic methods based on transition metal catalysis and various aspects of transition metal mediated free radical chemistry and their application to the synthesis of biologically active molecules.</span><br />
<h3 style="color: black; font-family: sans-serif;">
<a href="https://www.blogger.com/null" name="Selected_Publications"></a>Selected Publications</h3>
<ol style="color: #353535; font-family: sans-serif; font-size: medium; line-height: 17.6px;">
<li><i>Graphene-Catalyzed Direct Friedel-Crafts Alkylation Reactions: Mechanism, Selectivity and Synthetic Utility. </i>Hu, F.; Patel, M.; Luo, F.; Flach, C.; Mendelsohn, R.; Garfunkel, E.; He, H.; Szostak, M. <i>J. Am. Chem. Soc.</i> <b>2015</b>, <i>137</i> <a href="http://pubs.acs.org/doi/abs/10.1021/jacs.5b09636" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>General Olefin Synthesis by the Palladium-Catalyzed Heck Reaction of Amides: Sterically-Controlled Chemoselective N-C Activation. </i>Meng, G.; Szostak, M. <i>Angew. Chem. Int. Ed.</i> <b>2015</b>, <i>54</i><a href="http://dx.doi.org/10.1002/anie.201507776" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Aminoketyl Radicals in Organic Synthesis: Stereoselective Cyclization of 5- and 6-Membered Cyclic Imides to 2-Azabicycles using SmI<sub>2</sub>-H<sub>2</sub>O. </i>Shi S.; Szostak, M. <i>Org. Lett.</i> <b>2015</b>, <i>17</i>, 5144 <a href="http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b02732" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Sterically-Controlled Pd-Catalyzed Chemoselective Ketone Synthesis via N-C Cleavage in Twisted Amides. </i>Meng, G.; Szostak, M. <i>Org. Lett.</i> <b>2015</b>, <i>17</i> <a href="http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b02209" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Recent Developments in the Synthesis and Reactivity of Isoxazoles: Metal Catalysis and Beyond.</i>Hu, F.; Szostak, M. <i>Adv. Synth. Catal.</i> <b>2015</b>, <i>357</i>, 2583. <a href="http://dx.doi.org/10.1002/adsc.201500319" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Determination of Structures and Energetics of Small- and Medium-Sized One-Carbon Bridged Twisted Amides using ab Initio Molecular Orbital Methods. Implications for Amidic Resonance along the C-N Rotational Pathway. </i>Szostak, R.; Aubé, J.; Szostak, M. <i>J. Org. Chem. </i><b>2015</b>, <i>80</i>, 7905. <a href="http://dx.doi.org/10.1021/acs.joc.5b00881" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>An Efficient Computational Model to Predict Protonation at the Amide Nitrogen and Reactivity along the C-N Rotational Pathway. </i>Szostak, R.; Aubé, J.; Szostak, M. <i>Chem. Commun. </i><b>2015</b>, <i>51</i>, 6395.<a href="http://dx.doi.org/10.1039/c5cc01034a" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Pd-Catalyzed C-H Activation: Expanding the Portfolio of Metal-Catalyzed Functionalization of Unreactive C-H Bonds by Arene-Chromium π-Complexation. </i>Hu, F.; Szostak, M. <i>ChemCatChem</i><b>2015</b>, <i>7</i>, 1061. <a href="http://dx.doi.org/10.1002/cctc.201500080" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Highly Chemoselective Reduction of Amides (Primary, Secondary and Tertiary) to Alcohols using SmI<sub>2</sub>/H<sub>2</sub>O/Amine under Mild Conditions. </i>Szostak, M.; Spain, M.; Eberhart, A. J.; Procter, D. J. <i>J. Am. Chem. Soc.</i> <b>2014</b>, <i>136</i>, 2268. <a href="http://dx.doi.org/10.1021/ja412578t" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Substrate-Directable Electron Transfer Reactions. Dramatic Rate Enhancement in the Chemoselective Reduction of Cyclic Esters using SmI<sub>2</sub>-H<sub>2</sub>O: Mechanism, Scope and Synthetic Utility. </i>Szostak, M.; Spain, M.; Choquette, K. A.; Flowers, R. A., II; Procter, D. J. <i>J. Am. Chem. Soc.</i><b>2013</b>, <i>135</i>, 15702. <a href="http://dx.doi.org/10.1021/ja4078864" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Selective Reduction of Barbituric Acids using SmI<sub>2</sub>-H<sub>2</sub>O: Synthesis, Reactivity and Structural Analysis of Tetrahedral Adducts. </i>Szostak, M.; Spain, M.; Behlendorf, M; Procter, D. J. <i>Angew. Chem. Int. Ed.</i> <b>2013</b>, <i>52</i>, 12559. <a href="http://dx.doi.org/10.1002/anie.201306484" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Non-Classical Lanthanide(II) Iodides: Uncovering the Importance of Proton Donors in TmI<sub>2</sub>-Promoted Electron Transfer. Facile C-N Bond Cleavage in Unactivated Amides. </i>Szostak, M.; Spain, M.; Procter, D. J. <i>Angew. Chem. Int. Ed.</i> <b>2013</b>, <i>52</i>, 7237. <a href="http://dx.doi.org/10.1002/anie.201303178" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
<li><i>Chemistry of Bridged Lactams and Related Heterocycles. </i>Szostak, M.; Aubé, J. <i>Chem. Rev.</i> <b>2013</b>,<i>113</i>, 5701. <a href="http://dx.doi.org/10.1021/cr4000144" style="color: #ae0525; text-decoration: none;">[doi]</a></li>
</ol>
<span style="background-color: white; color: #353535; font-family: sans-serif; font-size: small; line-height: 17.6px;">For more detail, please see the </span><a href="http://szostakgroup.com/" style="color: #ae0525; font-family: sans-serif; font-size: medium; line-height: 17.6px; text-decoration: none;">Szostak Group Web Site </a><br />
<br />
<br />
<img alt="DSC_0080" src="https://szostakgroupcom.files.wordpress.com/2016/04/dsc_0080.jpg?w=624" /><br />
<br />
<br />
<br />
<br />
<header class="entry-header" style="background-color: white; border: 0px; color: #444444; font-family: "open sans", helvetica, arial, sans-serif; font-size: 14px; line-height: 14px; margin: 0px 0px 1.71429rem; padding: 0px; vertical-align: baseline;"><h1 class="entry-title" style="border: 0px; clear: both; font-size: 1.57143rem; font-weight: normal; line-height: 1.2; margin: 0px; padding: 0px; vertical-align: baseline;">
GROUP</h1>
</header><br />
<div class="entry-content" style="background-color: white; border: 0px; color: #444444; font-family: "open sans", helvetica, arial, sans-serif; font-size: 14px; line-height: 1.71429; margin: 0px; padding: 0px; vertical-align: baseline;">
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Prof. Michal Szostak</strong></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Assistant Professor</strong></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Ph.D., University of Kansas (2009) with Jeffrey Aubé</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Postdoctoral, Princeton University (2010) with David MacMillan</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Postdoctoral, University of Manchester (2011-2014) with David Procter<span style="line-height: 1.71429;"> </span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<span style="border: 0px; margin: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><em style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;"><strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Postdoctoral Researchers</strong></em></span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Dr. Feng Hu</strong></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Ph.D., Nanjing University, 2009 (Z. Huang)</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Postdoctoral, Shanghai Institute of Materia Medica (Y. Hu)</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Research Assistant Professor, SIOC (Q. Shen)</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Postdoctoral, Lamar University (X. Lei)<span style="line-height: 1.71429;"> </span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Dr. Pradeep Nareddy</strong></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Ph.D., University of Geneva, 2013 (C. Mazet)</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Postdoctoral, Leipzig University (C. Schneider)<span style="line-height: 1.71429;"> </span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<span style="border: 0px; margin: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><em style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;"><strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Graduate Students</strong></em></span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Shicheng Shi</strong></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
M.S., SIOC, 2013 (R. Wang)</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
B.S., Nanjing Agriculture University, 2010<span style="line-height: 1.71429;"> </span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Guangrong Meng</strong></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
M.S., Fudan University, 2014 (Q. Zhang)</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
B.S., Dalian Medical University, 2011<strong style="border: 0px; line-height: 1.71429; margin: 0px; padding: 0px; vertical-align: baseline;"> </strong></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Chengwei Liu</strong></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
M.S., Soochow University, 2014 (Y. Yao)</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
B.S., Zaozhuang University, 2011<span style="line-height: 1.71429;"> </span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<span style="border: 0px; margin: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><em style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;"><strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Undergraduate Students</strong></em></span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Syed Huq (Rutgers, Chemistry, 2014-present)</div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Marcel Achtenhagen (Rutgers, Chemistry, 2015-present)<span style="line-height: 1.71429;"> </span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
<span style="border: 0px; margin: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><em style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;"><strong style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Visiting Students</strong></em></span></div>
<div style="border: 0px; line-height: 1.71429; margin-bottom: 1.71429rem; padding: 0px; vertical-align: baseline;">
Yongmei Liu (Yangzhou University, R. Liu)</div>
</div>
<br /></div>
</div>
<div style="color: #333333; font-family: georgia, "times new roman", "bitstream charter", times, serif; font-size: 16px; line-height: 24px;">
<a data-mce-href="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/supinfo/anie201601914-sup-0001-misc_information.pdf?v=1&s=7cdabec31e78a92c0985c604be965dfee1c17521" href="http://onlinelibrary.wiley.com/store/10.1002/anie.201601914/asset/supinfo/anie201601914-sup-0001-misc_information.pdf?v=1&s=7cdabec31e78a92c0985c604be965dfee1c17521">/////</a>/Nickel-Catalyzed, Decarbonylative Suzuki–Miyaura Coupling, Amides, Biaryls</div>
</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com0tag:blogger.com,1999:blog-81273127788638440.post-6417545933550248502016-07-06T14:52:00.001+05:302016-07-06T14:54:41.334+05:30Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review<div dir="ltr" style="text-align: left;" trbidi="on">
<img align="middle" alt="image" border="0" class="" data-mce-src="http://ars.els-cdn.com/content/image/1-s2.0-S022352341530101X-fx1.jpg" src="http://ars.els-cdn.com/content/image/1-s2.0-S022352341530101X-fx1.jpg" height="376" title="image" width="640" />Highlights<br />
Modification of BHT has a significant multivariate effect on antioxidant efficiency.<br />
<div class="abstract svAbstract abstractHighlights " data-etype="ab">
<dl class="listitem" id="list_ulist0010">
<dt class="label">BDE is the key to rational design and development of antioxidants.</dt>
<dt class="label">Antioxidant performance of BHT is mainly depending on 13 very crucial parameters.</dt>
<dt class="label">MPAO is a promising way to increase antioxidant and pharmacological activities.</dt>
</dl>
</div>
<hr class="artHeader" id="abs_authorabs00101" />
<div class="abstract svAbstract " data-etype="ab">
<h2 class="secHeading" id="authorabs00101">
Abstract</h2>
<div id="abspara0010">
Hindered
phenols find a wide variety of applications across many different
industry sectors. Butylated hydroxytoluene (BHT) is a most commonly used
antioxidant recognized as safe for use in foods containing fats,
pharmaceuticals, petroleum products, rubber and oil industries. In the
past two decades, there has been growing interest in finding novel
antioxidants to meet the requirements of these industries. To accelerate
the antioxidant discovery process, researchers have designed and
synthesized a series of BHT derivatives targeting to improve its
antioxidant properties to be having a wide range of antioxidant
activities markedly enhanced radical scavenging ability and other
physical properties. Accordingly, some structure–activity relationships
and rational design strategies for antioxidants based on BHT structure
have been suggested and applied in practice. We have identified 14 very
sensitive parameters, which may play a major role on the antioxidant
performance of BHT. In this review, we attempt to summarize the current
knowledge on this topic, which is of significance in selecting and
designing novel antioxidants using a well-known antioxidant BHT as a
building-block molecule. Our strategy involved investigation on
understanding the chemistry behind the antioxidant activities of BHT,
whether through hydrogen or electron transfer mechanism to enable
promising anti-oxidant candidates to be synthesized.</div>
</div>
<br />
<div class="head headTemplate page_fragment_ind">
<div class="publicationHead">
<div class="title">
<a class="cLink" data-mce-href="http://www.sciencedirect.com/science/journal/02235234" href="http://www.sciencedirect.com/science/journal/02235234" title="Go to European Journal of Medicinal Chemistry on ScienceDirect">European Journal of Medicinal Chemistry</a></div>
<div class="volIssue">
<a class="S_C_volIss" data-mce-href="http://www.sciencedirect.com/science/journal/02235234/101/supp/C" href="http://www.sciencedirect.com/science/journal/02235234/101/supp/C" title="Go to table of contents for this volume/issue">Volume 101</a>, 28 August 2015, Pages 295–312</div>
</div>
<div class="publicationCover cover2">
<a class="cLink" data-mce-href="http://www.sciencedirect.com/science/journal/02235234/101/supp/C" href="http://www.sciencedirect.com/science/journal/02235234/101/supp/C"><img alt="Cover image" class="toprightlogo" data-mce-src="http://ars.els-cdn.com/content/image/1-s2.0-S0223523415X00109-cov150h.gif" src="http://ars.els-cdn.com/content/image/1-s2.0-S0223523415X00109-cov150h.gif" /></a></div>
</div>
<div class="page_fragment auth_frag" data-fid="1" data-first="true" id="frag_1">
<div class="publicationType" id="dhead0010">
<span id="">Review article</span></div>
<div class="module_topic_paths">
</div>
<h1 class="svTitle" id="title0010">
Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): A review</h1>
<ul class="authorGroup noCollab svAuthor">
<li class="smh5"><a class="authorName svAuthor" data-fn="Wageeh A." data-ln="Yehye" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" data-orcid="" data-pos="1" data-t="a" data-tb="" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" id="authname_N69949560N692fb2fc">Wageeh A. Yehye</a><a class="intra_ref auth_aff" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff1" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff1" id="baff1" title="Affiliation: a"><sup>a</sup></a><sup>, </sup><sup>, </sup>,</li>
<li class="smh5"><a class="authorName svAuthor" data-fn="Noorsaadah Abdul" data-ln="Rahman" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" data-orcid="" data-pos="2" data-t="a" data-tb="" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" id="authname_N69949560N692fb464">Noorsaadah Abdul Rahman</a><a class="intra_ref auth_aff" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff2" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff2" id="baff2" title="Affiliation: b"><sup>b</sup></a>,</li>
<li class="smh5"><a class="authorName svAuthor" data-fn="Azhar" data-ln="Ariffin" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" data-orcid="" data-pos="3" data-t="a" data-tb="" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" id="authname_N69949560N692fb518">Azhar Ariffin</a><a class="intra_ref auth_aff" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff2" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff2" id="baff2" title="Affiliation: b"><sup>b</sup></a>,</li>
<li class="smh5"><a class="authorName svAuthor" data-fn="Sharifah Bee" data-ln="Abd Hamid" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" data-orcid="" data-pos="4" data-t="a" data-tb="" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" id="authname_N69949560N692fb5cc">Sharifah Bee Abd Hamid</a><a class="intra_ref auth_aff" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff1" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff1" id="baff1" title="Affiliation: a"><sup>a</sup></a>,</li>
<li class="smh5"><a class="authorName svAuthor" data-fn="Abeer A." data-ln="Alhadi" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" data-orcid="" data-pos="5" data-t="a" data-tb="" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" id="authname_N69949560N692fb680">Abeer A. Alhadi</a><a class="intra_ref auth_aff" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff2" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff2" id="baff2" title="Affiliation: b"><sup>b</sup></a>,</li>
<li class="smh5"><a class="authorName svAuthor" data-fn="Farkaad A." data-ln="Kadir" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" data-orcid="" data-pos="6" data-t="a" data-tb="" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" id="authname_N69949560N692fb734">Farkaad A. Kadir</a><a class="intra_ref auth_aff" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff3" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff3" id="baff3" title="Affiliation: c"><sup>c</sup></a>,</li>
<li class="smh5"><a class="authorName svAuthor" data-fn="Marzieh" data-ln="Yaeghoobi" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" data-orcid="" data-pos="7" data-t="a" data-tb="" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#" id="authname_N69949560N692fb7e8">Marzieh Yaeghoobi</a><a class="intra_ref auth_aff" data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff4" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X#aff4" id="baff4" title="Affiliation: d"><sup>d</sup></a></li>
</ul>
<ul class="affiliation authAffil smh">
<li class="smh5plus" id="aff1"><sup>a</sup><span id="">Nanotechnology
& Catalysis Research Centre, (NANOCAT), University of Malaya, Block
3A, Institute of Postgraduate Studies Building, 50603 Kuala Lumpur,
Malaysia</span></li>
<li class="smh5plus" id="aff2"><sup>b</sup><span id="">Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia</span></li>
<li class="smh5plus" id="aff3"><sup>c</sup><span id="">Division of Human Biology, Faculty of Medicine, International Medical University, 57000 Kuala Lumpur, Malaysia</span></li>
<li class="smh5plus" id="aff4"><sup>d</sup><span id="">Drug
Design and Development Research Group, Department of Chemistry, Faculty
of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia</span></li>
<li class="smh5plus"><a data-mce-href="http://www.sciencedirect.com/science/article/pii/S022352341530101X" href="http://www.sciencedirect.com/science/article/pii/S022352341530101X">http://www.sciencedirect.com/science/article/pii/S022352341530101X</a></li>
</ul>
<a class="S_C_ddDoi" data-mce-href="http://dx.doi.org/10.1016/j.ejmech.2015.06.026" href="http://dx.doi.org/10.1016/j.ejmech.2015.06.026" id="ddDoi" target="doilink">doi:10.1016/j.ejmech.2015.06.026</a></div>
<ul data-reactid="69" id="yui_3_14_1_1_1467790097087_880">
<li class="publication-author-list-item" data-reactid="70" id="yui_3_14_1_1_1467790097087_879"><div class="publication-author-list-item-info" data-reactid="71" id="yui_3_14_1_1_1467790097087_860">
<a class="publication-author-image ga-author-image" data-mce-href="https://www.researchgate.net/profile/Wageeh_Yehye2" data-reactid="72" href="https://www.researchgate.net/profile/Wageeh_Yehye2"><img alt="" class="publication-author-list-item-image" data-mce-src="https://i1.rgstatic.net/ii/profile.image/AS%3A273674326507524%401442260452567_m/Wageeh_Yehye2.png" data-reactid="73" height="333" src="https://i1.rgstatic.net/ii/profile.image/AS%3A273674326507524%401442260452567_m/Wageeh_Yehye2.png" width="333" /></a><br />
<div class="publication-author-list-item-text" data-reactid="74" id="yui_3_14_1_1_1467790097087_1421">
<div class="publication-author-name-line" data-reactid="75" id="yui_3_14_1_1_1467790097087_1422">
<span class="publication-author-position" data-reactid="76">1st</span> <a class="publication-author-name ga-author-name" data-mce-href="https://www.researchgate.net/profile/Wageeh_Yehye2" data-reactid="78" href="https://www.researchgate.net/profile/Wageeh_Yehye2">Wageeh Yehye</a></div>
<div class="publication-author-stats-line" data-reactid="79" id="yui_3_14_1_1_1467790097087_1420">
University of Malaya</div>
</div>
</div>
</li>
<li class="publication-author-list-item" data-reactid="84" id="yui_3_14_1_1_1467790097087_1581"><div class="publication-author-list-item-info" data-reactid="85" id="yui_3_14_1_1_1467790097087_1662">
<a class="publication-author-image ga-author-image" data-mce-href="https://www.researchgate.net/profile/Noor_Rahman" data-reactid="86" href="https://www.researchgate.net/profile/Noor_Rahman"><img alt="" class="publication-author-list-item-image" data-mce-src="https://c5.rgstatic.net/m/2671872220764/images/template/default/profile/profile_default_m.jpg" data-reactid="87" src="https://c5.rgstatic.net/m/2671872220764/images/template/default/profile/profile_default_m.jpg" /></a><br />
<div class="publication-author-list-item-text" data-reactid="88" id="yui_3_14_1_1_1467790097087_1709">
<div class="publication-author-name-line" data-reactid="89" id="yui_3_14_1_1_1467790097087_1710">
<span class="publication-author-position" data-reactid="90">2nd</span> <a class="publication-author-name ga-author-name" data-mce-href="https://www.researchgate.net/profile/Noor_Rahman" data-reactid="92" href="https://www.researchgate.net/profile/Noor_Rahman">Noor Rahman</a></div>
<div class="publication-author-stats-line" data-reactid="93" id="yui_3_14_1_1_1467790097087_1708">
University of Malaya</div>
</div>
</div>
</li>
<li class="publication-author-list-item" data-reactid="98" id="yui_3_14_1_1_1467790097087_974"><div class="publication-author-list-item-info" data-reactid="104" id="yui_3_14_1_1_1467790097087_1233">
<a class="publication-author-image ga-author-image" data-mce-href="https://www.researchgate.net/profile/Azhar_Ariffin" data-reactid="105" href="https://www.researchgate.net/profile/Azhar_Ariffin"><img alt="" class="publication-author-list-item-image" data-mce-src="https://i1.rgstatic.net/ii/profile.image/AS%3A272277635858433%401441927455171_m/Azhar_Ariffin.png" data-reactid="106" height="238" src="https://i1.rgstatic.net/ii/profile.image/AS%3A272277635858433%401441927455171_m/Azhar_Ariffin.png" width="238" /></a><br />
<div class="publication-author-list-item-text" data-reactid="107" id="yui_3_14_1_1_1467790097087_1335">
<div class="publication-author-name-line" data-reactid="108" id="yui_3_14_1_1_1467790097087_1337">
<span class="publication-author-position" data-reactid="109">3rd</span> <a class="publication-author-name ga-author-name" data-mce-href="https://www.researchgate.net/profile/Azhar_Ariffin" data-reactid="111" href="https://www.researchgate.net/profile/Azhar_Ariffin" id="yui_3_14_1_1_1467790097087_2003">Azhar Ariffin</a></div>
<div class="publication-author-stats-line" data-reactid="112" id="yui_3_14_1_1_1467790097087_1334">
University of Malaya</div>
</div>
</div>
</li>
<li class="publication-author-list-item" id="yui_3_14_1_1_1467790097087_1480"><div class="publication-author-list-item-info" id="yui_3_14_1_1_1467790097087_1461">
<a class="publication-author-image ga-author-image" data-mce-href="https://www.researchgate.net/profile/Sharifah_Bee_Abd_Hamid" href="https://www.researchgate.net/profile/Sharifah_Bee_Abd_Hamid"><img alt="" class="publication-author-list-item-image" data-mce-src="https://c5.rgstatic.net/m/2671872220764/images/template/default/profile/profile_default_m.jpg" src="https://c5.rgstatic.net/m/2671872220764/images/template/default/profile/profile_default_m.jpg" /></a><br />
<div class="publication-author-list-item-text" id="yui_3_14_1_1_1467790097087_1707">
<div class="publication-author-name-line" id="yui_3_14_1_1_1467790097087_1706">
<span class="publication-author-position">4th</span> <a class="publication-author-name ga-author-name" data-mce-href="https://www.researchgate.net/profile/Sharifah_Bee_Abd_Hamid" href="https://www.researchgate.net/profile/Sharifah_Bee_Abd_Hamid">Sharifah Bee Abd Hamid</a></div>
<div class="publication-author-stats-line">
University of Malaya</div>
</div>
</div>
</li>
<li class="publication-author-list-item" id="yui_3_14_1_1_1467790097087_1918"><div class="publication-author-list-item-info" id="yui_3_14_1_1_1467790097087_2002">
<a class="publication-author-image ga-author-image" data-mce-href="https://www.researchgate.net/profile/Abeer_Abdulqader" href="https://www.researchgate.net/profile/Abeer_Abdulqader"><img alt="" class="publication-author-list-item-image" data-mce-src="https://i1.rgstatic.net/ii/profile.image/AS%3A360404380340224%401462938508051_m/Abeer_Abdulqader.png" height="258" src="https://i1.rgstatic.net/ii/profile.image/AS%3A360404380340224%401462938508051_m/Abeer_Abdulqader.png" width="258" /></a><br />
<div class="publication-author-list-item-text" id="yui_3_14_1_1_1467790097087_2001">
<div class="publication-author-name-line">
<span class="publication-author-position">5th</span> <a class="publication-author-name ga-author-name" data-mce-href="https://www.researchgate.net/profile/Abeer_Abdulqader" href="https://www.researchgate.net/profile/Abeer_Abdulqader">Abeer Abdulhadi Abdulqader</a></div>
<div class="publication-author-stats-line" id="yui_3_14_1_1_1467790097087_2000">
University of Malaya</div>
</div>
</div>
</li>
<li class="publication-author-list-item" id="yui_3_14_1_1_1467790097087_1773"><div class="publication-author-list-item-info" id="yui_3_14_1_1_1467790097087_1754">
<a class="publication-author-image ga-author-image" data-mce-href="https://www.researchgate.net/profile/Farkaad_Kadir" href="https://www.researchgate.net/profile/Farkaad_Kadir"><img alt="" class="publication-author-list-item-image" data-mce-src="https://c5.rgstatic.net/m/2671872220764/images/template/default/profile/profile_default_m.jpg" src="https://c5.rgstatic.net/m/2671872220764/images/template/default/profile/profile_default_m.jpg" /></a><br />
<div class="publication-author-list-item-text" id="yui_3_14_1_1_1467790097087_1897">
<div class="publication-author-name-line">
<span class="publication-author-position">6th</span> <a class="publication-author-name ga-author-name" data-mce-href="https://www.researchgate.net/profile/Farkaad_Kadir" href="https://www.researchgate.net/profile/Farkaad_Kadir">Farkaad A Kadir</a></div>
<div class="publication-author-stats-line" id="yui_3_14_1_1_1467790097087_1896">
International Medical University (IMU)</div>
</div>
</div>
</li>
<li class="publication-author-list-item" data-reactid="117" id="yui_3_14_1_1_1467790097087_1151"><div class="publication-author-list-item-info" data-reactid="118" id="yui_3_14_1_1_1467790097087_1132">
<a class="publication-author-image ga-author-image" data-mce-href="https://www.researchgate.net/profile/Marzieh_Yaeghoobi" data-reactid="119" href="https://www.researchgate.net/profile/Marzieh_Yaeghoobi" id="yui_3_14_1_1_1467790097087_1427"><img alt="" class="publication-author-list-item-image" data-mce-src="https://i1.rgstatic.net/ii/profile.image/AS%3A279033947410456%401443538285993_m/Marzieh_Yaeghoobi.png" data-reactid="120" height="227" id="yui_3_14_1_1_1467790097087_1426" src="https://i1.rgstatic.net/ii/profile.image/AS%3A279033947410456%401443538285993_m/Marzieh_Yaeghoobi.png" width="227" /></a><br />
<div class="publication-author-list-item-text" data-reactid="121" id="yui_3_14_1_1_1467790097087_1434">
<div class="publication-author-name-line" data-reactid="122" id="yui_3_14_1_1_1467790097087_1433">
<span class="publication-author-position" data-reactid="123" id="yui_3_14_1_1_1467790097087_1435">7th</span> <a class="publication-author-name ga-author-name" data-mce-href="https://www.researchgate.net/profile/Marzieh_Yaeghoobi" data-reactid="125" href="https://www.researchgate.net/profile/Marzieh_Yaeghoobi" id="yui_3_14_1_1_1467790097087_1432">Marzieh Yaeghoobi</a></div>
<div class="publication-author-stats-line" data-reactid="126" id="yui_3_14_1_1_1467790097087_1437">
University of Malaya</div>
</div>
</div>
</li>
</ul>
SEE<br />
<a data-mce-href="https://www.researchgate.net/publication/278050005_ChemInform_Abstract_Understanding_the_Chemistry_Behind_the_Antioxidant_Activities_of_Butylated_Hydroxytoluene_BHT_A_Review/figures" href="https://www.researchgate.net/publication/278050005_ChemInform_Abstract_Understanding_the_Chemistry_Behind_the_Antioxidant_Activities_of_Butylated_Hydroxytoluene_BHT_A_Review/figures">https://www.researchgate.net/publication/278050005_ChemInform_Abstract_Understanding_the_Chemistry_Behind_the_Antioxidant_Activities_of_Butylated_Hydroxytoluene_BHT_A_Review/figures</a><br />
<br />
<img alt="" data-mce-src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig7/AS:327394129924102@1455068251647/Fig-13-Stereoelectronic-effects-of-heteroatoms-on-stabilization-of-free-radical.png" src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig7/AS:327394129924102@1455068251647/Fig-13-Stereoelectronic-effects-of-heteroatoms-on-stabilization-of-free-radical.png" /><br />
<img alt="" data-mce-src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig11/AS:327394129924106@1455068251889/Fig-19-SAR-analysis-of-MPAO-1-acylthiosemicarbazide-as-an-MPAO-110127.png" src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig11/AS:327394129924106@1455068251889/Fig-19-SAR-analysis-of-MPAO-1-acylthiosemicarbazide-as-an-MPAO-110127.png" /><br />
<br />
<img alt="" data-mce-src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig1/AS:327394129924096@1455068251453/Fig-4-Increasing-of-BDE-of-some-substituted-phenols.png" src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig1/AS:327394129924096@1455068251453/Fig-4-Increasing-of-BDE-of-some-substituted-phenols.png" /><br />
<br />
<img alt="" data-mce-src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig2/AS:327394129924097@1455068251485/Fig-5-BDE-values-kcalmol-of-the-OeH-bond-of-p-substituted-BHT-in-benzene-97.png" src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig2/AS:327394129924097@1455068251485/Fig-5-BDE-values-kcalmol-of-the-OeH-bond-of-p-substituted-BHT-in-benzene-97.png" /><br />
<br />
<img alt="" data-mce-src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/viewer/AS:327394062815233@1455068235563/background/7.png" src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/viewer/AS:327394062815233@1455068235563/background/7.png" /><br />
<img alt="" data-mce-src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig4/AS:327394129924099@1455068251547/Fig-10-Steric-hindrance-effects-on-stabilization-of-phenolic-antioxidants.png" src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig4/AS:327394129924099@1455068251547/Fig-10-Steric-hindrance-effects-on-stabilization-of-phenolic-antioxidants.png" /><br />
<img alt="" data-mce-src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig5/AS:327394129924100@1455068251584/Fig-11-BDE-values-of-phenol-and-BHA.png" src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig5/AS:327394129924100@1455068251584/Fig-11-BDE-values-of-phenol-and-BHA.png" /><br />
<b><img alt="" data-mce-src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig6/AS:327394129924101@1455068251621/Fig-12-The-effect-of-the-hydrogen-bonding-on-antioxidant-activities.png" src="https://www.researchgate.net/profile/Abeer_Abdulqader/publication/278050005/figure/fig6/AS:327394129924101@1455068251621/Fig-12-The-effect-of-the-hydrogen-bonding-on-antioxidant-activities.png" /></b><br />
///////////<span id="">Antioxidant, </span><span id="">Butylated hydroxytoluene, </span><span id="">Free radical, </span><span id="">Reactive oxygen species, </span>Phenol</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com0tag:blogger.com,1999:blog-81273127788638440.post-41447752798491436962016-06-07T12:40:00.000+05:302016-06-07T12:46:51.731+05:30Multicomponent Multicatalyst Reactions (MC)2R: One-Pot Synthesis of 3,4-Dihydroquinolinones<div dir="ltr" style="text-align: left;" trbidi="on">
<table id="pubs" style="background-color: white; font-family: Arial, sans-serif; width: 810px;"><tbody>
<tr><td style="vertical-align: middle;"><br /></td></tr>
<tr><td colspan="2" style="vertical-align: middle;"><center style="text-align: left;">
<img class="pubimg" height="347" src="https://www.chem.utoronto.ca/staff/ML/publications/2013Org.%20Lett.2128.PNG" style="border: 0px; margin: 10px; max-width: 600px;" width="640" /></center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
<span class="pubtit" style="color: #6699ff; font-style: italic; font-weight: bold;">Multicomponent Multicatalyst Reactions (MC)2R: </span></center>
<center style="text-align: left;">
<span class="pubtit" style="color: #6699ff; font-style: italic; font-weight: bold;">One-Pot Synthesis of 3,4-Dihydroquinolinones</span></center>
<center style="text-align: left;">
<span class="pubaut">Lei Zhang, Lorenzo Sonaglia, Jason Stacey, and Mark Lautens</span> <span class="pubjou" style="font-style: italic;">Org. Lett.</span> <span class="pubyea" style="font-weight: bold;">2013</span>, <span class="pubvol" style="font-style: italic;">15</span>, <span class="pubpag">2128-2131.</span> <span class="doi">DOI:<a href="http://dx.doi.org/10.1021/ol4006008" target="_blank">10.1021/ol4006008 </a>.</span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi"><span style="background-color: #f4f9fd; font-family: "helvetica" , "arial" , sans-serif; font-size: 14px; line-height: 22.3999996185303px;">A Rh/Pd/Cu catalyst system led to an efficient synthesis of dihydroquinolinones in one-pot, two operations. The reaction features the first triple metal-catalyzed transformations in one reaction vessel, without any intermediate workup. The conjugate-addition/amidation/amidation reaction sequence is highly modular, divergent, and practical.</span></span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi"><h1 class="articleTitle" style="font-family: Helvetica, Arial, sans-serif; font-size: 20px; margin-top: 0px;">
<span class="hlFld-Title">Multicomponent Multicatalyst Reactions (MC)<span style="font-size: 0.8em; line-height: 0.8em; vertical-align: 0.4em;">2</span>R: One-Pot Synthesis of 3,4-Dihydroquinolinones</span></h1>
<div id="articleMeta" style="font-family: Helvetica, Arial, sans-serif; font-size: 13px; line-height: 1.3em; margin-top: 15px;">
<div id="authors" style="color: #333333; font-size: 1em; font-weight: bold;">
<span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Zhang%2C+Lei" id="authors" style="border-bottom-color: rgb(51, 102, 153); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 1em; text-decoration: none;">Lei Zhang</a></span><span class="NLM_x"><x xml:space="preserve" xmlns:acs="http://namespace.acs.org/2008/acs" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">, </x></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Sonaglia%2C+Lorenzo" id="authors" style="border-bottom-color: rgb(51, 102, 153); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 1em; text-decoration: none;">Lorenzo Sonaglia</a></span><span class="NLM_x"><x xml:space="preserve" xmlns:acs="http://namespace.acs.org/2008/acs" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">, </x></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Stacey%2C+Jason" id="authors" style="border-bottom-color: rgb(51, 102, 153); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 1em; text-decoration: none;">Jason Stacey</a></span><span class="NLM_x"><x xml:space="preserve" xmlns:acs="http://namespace.acs.org/2008/acs" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">, and </x></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Lautens%2C+Mark" id="authors" style="border-bottom-color: rgb(51, 102, 153); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 1em; text-decoration: none;">Mark Lautens</a></span><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/ol4006008#cor1" style="color: #336699; text-decoration: none;">*</a><span class="NLM_x"></span></span></div>
<div class="affiliations">
<div id="aff1">
Davenport Research Laboratories, Department of Chemistry, <span class="institution">University of Toronto</span>, 80 St George Street, Toronto, Ontario M5S 3H6, Canada</div>
</div>
<div id="citation" style="font-size: 0.9em; margin: 10px 0px 0px;">
<cite>Org. Lett.</cite>, <span class="citation_year" style="font-weight: bold;">2013</span>, <span class="citation_volume" style="font-style: italic;">15</span> (9), pp 2128–2131</div>
<div id="doi" style="font-size: 0.9em;">
<strong>DOI: </strong>10.1021/ol4006008</div>
<div id="pubDate" style="font-size: 0.9em;">
Publication Date (Web): April 19, 2013</div>
<div id="artCopyright" style="font-size: 0.9em; font-weight: bold;">
Copyright © 2013 American Chemical Society</div>
<div id="correspondence" style="color: #666666; font-size: 0.9em; margin: 7px 0px 0px; width: auto;">
<a href="mailto:mlautens@chem.utoronto.ca" style="color: #336699; text-decoration: none;">mlautens@chem.utoronto.ca</a></div>
</div>
</span></center>
<center style="text-align: left;">
<span class="doi"><a href="http://pubs.acs.org/doi/abs/10.1021/ol4006008">http://pubs.acs.org/doi/abs/10.1021/ol4006008</a></span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi">Mark Lautens</span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi"><img height="637" src="data:image/jpeg;base64,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" width="640" /></span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi"><div id="heading" style="background-color: #87998c; border-bottom-color: rgb(48, 48, 48); border-bottom-style: solid; border-bottom-width: 2px; color: #3c3c3c; font-family: Calibri, ArialMT, Arial, sans-serif; font-size: 50px; font-weight: bold; padding: 0px 0px 0px 20px;">
Mark Lautens , <a href="http://www.gg.ca/document.aspx?id=15922&lan=eng" target="_blank">O.C.</a></div>
<br style="font-family: Arial, sans-serif;" /><br style="font-family: Arial, sans-serif;" /><h3 style="font-family: Arial, sans-serif; line-height: 1.7em;">
<a href="http://www.provost.utoronto.ca/Awards/uprofessors.htm" target="_blank">University Professor</a><br />J. Bryan Jones Distinguished Professor<br />AstraZeneca Professor of Organic Chemistry<br />NSERC/Merck-Frosst Industrial Research Chair</h3>
<br clear="all" style="font-family: Arial, sans-serif;" /><img src="https://www.chem.utoronto.ca/staff/ML/images/davenport1.jpg" style="border: 2px solid rgb(48, 48, 48); clear: left; float: left; font-family: Arial, sans-serif; margin: 20px 20px 0px; width: 250px;" /><br style="font-family: Arial, sans-serif;" /><br style="font-family: Arial, sans-serif;" /><br style="font-family: Arial, sans-serif;" /><br style="font-family: Arial, sans-serif;" /><br style="font-family: Arial, sans-serif;" /><div style="float: left; font-family: Arial, sans-serif; width: 300px;">
<b>Department of Chemistry</b><br />
Davenport Chemical Laboratories<br />
80 St. George St.<br />
University of Toronto<br />
Toronto, Ontario<br />
M5S 3H6</div>
<div style="float: left; font-family: Arial, sans-serif; width: auto;">
<br />
Tel: (416) 978-6083<br />
Fax: (416) 946-8185<br />
E-Mail: <a href="mailto:mlautens@chem.utoronto.ca">mlautens@chem.utoronto.ca</a></div>
</span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<span class="doi"><br /></span></center>
<center style="text-align: left;">
<h2 style="color: #944f40; font-family: Arial, sans-serif; text-align: center;">
<i>Curriculum Vitae</i></h2>
<center style="font-family: Arial, sans-serif;">
<table style="width: 810px;"><tbody>
<tr><td colspan="3"><h4 style="margin-left: 100px; margin-top: 40px;">
Personal</h4>
</td></tr>
<tr><td>Place and Date of Birth</td><td>Hamilton, Ontario, Canada</td><td>July 9, 1959</td></tr>
<tr><td colspan="3"><h4 style="margin-left: 100px; margin-top: 40px;">
Education</h4>
</td></tr>
<tr><td>Harvard University</td><td>NSERC PDF with D. A. Evans</td><td>1985 - 1987</td></tr>
<tr><td>University of Wisconsin-Madison</td><td>Ph.D. with B. M. Trost</td><td>1985</td></tr>
<tr><td>University of Guelph</td><td>B.Sc. - Distinction</td><td>1981</td></tr>
<tr><td colspan="3"><h4 style="margin-left: 100px; margin-top: 40px;">
Academic Positions</h4>
</td></tr>
<tr><td>J. Bryan Jones Distinguished Professor</td><td>University of Toronto</td><td>2013 - 2018</td></tr>
<tr><td>University Professor</td><td>University of Toronto</td><td>2012 - present</td></tr>
<tr><td>NSERC/Merck Frosst Industrial Research Chair</td><td>NSERC/Merck Frosst</td><td>2003 - 2013</td></tr>
<tr><td>AstraZeneca Professor of Organic Synthesis</td><td>University of Toronto</td><td>1998 - present</td></tr>
<tr><td>Professor</td><td>University of Toronto</td><td>1995 - 1998</td></tr>
<tr><td>Associate Professor</td><td>University of Toronto</td><td>1992 - 1995</td></tr>
<tr><td>Assistant Professor</td><td>University of Toronto</td><td>1987 - 1992</td></tr>
<tr><td colspan="3"><h4 style="margin-left: 100px; margin-top: 40px;">
Awards & Honors</h4>
</td></tr>
<tr><td>University of Toronto Alumni Faculty Award</td><td>University of Toronto</td><td>2016</td></tr>
<tr><td>CIC Catalysis Award</td><td>CSC</td><td>2016</td></tr>
<tr><td>Officer of the Order of Canada</td><td>Governor General</td><td>2014</td></tr>
<tr><td>Killam Research Fellowship</td><td>Canada Council for the Arts</td><td>2013-2015</td></tr>
<tr><td>CIC Medal</td><td>Chemical Institute of Canada</td><td>2013</td></tr>
<tr><td>Fellow of the Royal Society of UK</td><td>Royal Society of Chemistry</td><td>2011</td></tr>
<tr><td>Pedler Award</td><td>Royal Society of Chemistry</td><td>2011</td></tr>
<tr><td>Senior Scientist Award</td><td>Alexander von Humboldt Foundation<br />
Berlin, Aachen and Gottingen</td><td>2009-2014</td></tr>
<tr><td>Visiting Professor</td><td>University of Berlin</td><td>2009</td></tr>
<tr><td>Visiting Professor</td><td>Université de Marseilles</td><td>2008</td></tr>
<tr><td>ICIQ Summer School</td><td>ICIQ Tarragona, Spain</td><td>2008</td></tr>
<tr><td>Attilio Corbella Summer School Professor</td><td>Italian Chemical Society</td><td>2007</td></tr>
<tr><td>Arthur C. Cope Scholar Award</td><td>American Chemical Society</td><td>2006</td></tr>
<tr><td>Alfred Bader Award</td><td>Canadian Society for Chemistry</td><td>2006</td></tr>
<tr><td>R. U. Lemieux Award</td><td>Canadian Society for Chemistry</td><td>2004</td></tr>
<tr><td>Solvias Prize</td><td>Solvias AG</td><td>2002</td></tr>
<tr><td>Fellow of the Royal Society of Canada</td><td>Royal Society of Canada</td><td>2001</td></tr>
<tr><td colspan="3"><h4 style="margin-left: 100px; margin-top: 40px;">
Areas of Research Interest and Expertise</h4>
</td></tr>
<tr><td colspan="3"><ul style="line-height: 1.3em; margin-left: 50px;">
<li>new synthetic methods</li>
<li>metal catalyzed cycloaddition and annulation reactions</li>
<li>asymmetric catalysis with focus on rhodium, nickel and palladium catalysts</li>
<li>cyclopropane synthesis and reactions</li>
<li>hydrometallation reactions</li>
<li>reactions of organosilicon and organotin compounds</li>
<li>fragmentation reactions</li>
<li>new routes to medicinally/biologically interesting compounds</li>
<li>heterocycle synthesis using metal catalysts</li>
</ul>
</td></tr>
</tbody></table>
</center>
</center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
</center>
<center style="text-align: left;">
<span class="doi"><a href="http://pubs.acs.org/doi/suppl/10.1021/ol4006008">///////</a>/////</span></center>
</td></tr>
</tbody></table>
</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com0tag:blogger.com,1999:blog-81273127788638440.post-34713911989210741082016-06-04T08:37:00.002+05:302016-06-04T08:45:30.724+05:30Heterogeneous catalytic approaches in C-H activation reactions<div dir="ltr" style="text-align: left;" trbidi="on">
<h4 class="itemtitle" style="-webkit-text-stroke-width: 0px; background-color: #dddddd; color: black; font-family: Helvetica, Arial, sans-serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: 700; letter-spacing: -0.25px; line-height: normal; margin: 0px; orphans: auto; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 1; word-spacing: 0px;">
</h4>
<div class="itemcontent" name="decodeable" style="-webkit-text-stroke-width: 0px; background-color: #dddddd; color: black; font-family: Helvetica, Arial, sans-serif; font-size: 14px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 18.2px; orphans: auto; overflow: hidden; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 1; width: 693px; word-spacing: 0px;">
<div>
<div style="margin: 0px 0px 1em; padding: 0px;">
<img align="middle" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6GC00385K" height="640" width="640" /></div>
</div>
<div>
<i><b>Green Chem.</b></i>, 2016, Advance Article<br />
<b>DOI</b>: 10.1039/C6GC00385K, Critical Review</div>
<div>
Stefano Santoro, Sergei I. Kozhushkov, Lutz Ackermann, Luigi Vaccaro<br />
This review summarizes the development of user-friendly, recyclable and easily separable heterogeneous catalysts for C-H activation during the last decade until December 2015.</div>
</div>
<a href="https://www.blogger.com/goog_1226688156"><br /></a>
<a href="http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00385K?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract">http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00385K?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract</a><br />
<br />
<div style="background-color: white; color: #222222; font-family: Arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 18px; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
<span style="font-size: small;">Despite the undisputed advances and progress in metal-catalyzed C–H functionalizations, this atom-economical approach had thus far largely been developed with the aid of various metal catalysts that were operative in a homogeneous fashion. </span></div>
<div style="background-color: white; color: #222222; font-family: Arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 18px; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
<br /></div>
<div style="background-color: white; color: #222222; font-family: Arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 18px; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
<span style="font-size: small;">While thereby major progress was accomplished, these catalytic systems featured notable disadvantages, such as low catalyst recyclability. This review summarizes the development of user-friendly, recyclable and easily separable heterogeneous catalysts for C–H activation.</span></div>
<div style="background-color: white; color: #222222; font-family: Arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 18px; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
<br /></div>
<div style="background-color: white; color: #222222; font-family: Arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 18px; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
<span style="font-size: small;">This strategy was characterized by a remarkably broad substrate scope, considerable levels of chemo- and site-selectivities and proved applicable to C–C as well as C–heteroatom formation processes. </span></div>
<div style="background-color: white; color: #222222; font-family: Arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 18px; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
<br /></div>
<div style="background-color: white; color: #222222; font-family: Arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 18px; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
<span style="font-size: small;">Thus, recyclable catalysts were established for arylations, hydroarylations, alkenylations, acylations, nitrogenations, oxygenations, or halogenations, among others. The rapid recent progress in selective heterogeneous C–H functionalizations during the last decade until December 2015 is reviewed.</span></div>
<br class="Apple-interchange-newline" />
<br />
<div class="article_chemsoc_txt_s13" style="-webkit-text-stroke-width: 0px; background-color: white; color: #003c73; float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 18px; margin-bottom: 5px; orphans: auto; padding-left: 10px; padding-right: 10px; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 1; width: 520px; word-spacing: 0px;">
<h2 class="alpH1" style="color: #003c73; float: left; font-family: Arial; font-size: 14px; font-weight: normal; letter-spacing: 0em; line-height: 21px; margin: 0px; padding: 0px;">
Heterogeneous catalytic approaches in C–H activation reactions</h2>
</div>
<div class="peptide_wrap_s10_left" style="-webkit-text-stroke-width: 0px; background-color: white; color: black; float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: normal; height: auto; letter-spacing: normal; line-height: 16px; orphans: auto; padding-left: 10px; padding-top: 5px; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 1; width: 370px; word-spacing: 0px;">
<div class="peptide_middle" style="float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 20px; width: 360px;">
<div>
<span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AStefano%20Santoro" style="color: black; position: relative; text-decoration: underline;">Stefano Santoro</a>,<sup>a</sup> </span><span class="Apple-converted-space"> </span><span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3ASergei%20I.%20Kozhushkov" style="color: black; position: relative; text-decoration: underline;">Sergei I. Kozhushkov</a>,<sup>b</sup> </span><span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3ALutz%20Ackermann" style="color: black; position: relative; text-decoration: underline;">Lutz Ackermann</a><span style="font-size: 16px;">*</span><sup>b</sup> and </span><span class="Apple-converted-space"> </span><span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3ALuigi%20Vaccaro" style="color: black; position: relative; text-decoration: underline;">Luigi Vaccaro</a><span style="font-size: 16px;">*</span><sup>a</sup> </span></div>
<div class="show_affiliation_section" id="aff_info" style="background-color: #eef1f6; display: block; float: left; margin-bottom: 5px; padding: 0px 3px 10px 5px; width: 360px;">
<div class="show_aff_content" style="padding-top: 5px; width: 360px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
*</div>
<div style="padding-left: 10px;">
Corresponding authors</div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 360px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">a</sup></div>
<div style="padding-left: 10px;">
Laboratory of Green Synthetic Organic Chemistry, Dipartimento di Chimica Biologia e Biotecnologie, Università di Perugia, Via Elce di Sotto, 8 – 06123 Perugia, Italy<span class="Apple-converted-space"> </span><br />
<b>E-mail:<span class="Apple-converted-space"> </span></b><a href="mailto:luigi.vaccaro@unipg.it" style="color: #014682; position: relative; text-decoration: none;" title="luigi.vaccaro@unipg.it">luigi.vaccaro@unipg.it</a><br />
<b>Web:<span class="Apple-converted-space"> </span></b>http://www.dcbb.unipg.it/greensoc</div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 360px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">b</sup></div>
<div style="padding-left: 10px;">
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany<span class="Apple-converted-space"> </span><br />
<b>E-mail:<span class="Apple-converted-space"> </span></b><a href="mailto:Lutz.Ackermann@chemie.uni-goettingen.de" style="color: #014682; position: relative; text-decoration: none;" title="Lutz.Ackermann@chemie.uni-goettingen.de">Lutz.Ackermann@chemie.uni-goettingen.de</a><br />
<b>Web:<span class="Apple-converted-space"> </span></b>http://www.ackermann.chemie.uni-goettingen.de</div>
</div>
</div>
<div class="red_txt_s4" style="color: black; float: left; font-size: 12px; line-height: 18px; width: 360px;">
<i><b>Green Chem.</b></i>, 2016, Advance Article</div>
<br />
<span class="DOILink" style="float: left; font-size: 12px; padding: 0px; width: 505px;"><b>DOI:<span class="Apple-converted-space"> </span></b>10.1039/C6GC00385K</span><span class="DOILink" style="float: left; font-size: 12px; padding: 0px; width: 505px;"> </span><span class="DOILink" style="float: left; font-size: 12px; padding: 0px; width: 505px;"> </span><span class="DOILink" style="float: left; font-size: 12px; padding: 0px; width: 505px;"> </span><span class="DOILink" style="float: left; font-size: 12px; padding: 0px; width: 505px;"> </span><span class="DOILink" style="float: left; font-size: 12px; padding: 0px; width: 505px;"> </span></div>
</div>
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<img alt="" class="irc_mut iHV593wI1k_s-HwpH6ZlgJaI" height="393" src="data:image/jpeg;base64,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" style="margin-top: 0px;" width="294" /><br />
<div style="padding-left: 10px;">
Laboratory
of Green Synthetic Organic Chemistry, Dipartimento di Chimica Biologia e
Biotecnologie, Università di Perugia, Via Elce di Sotto, 8 – 06123
Perugia, Italy<span class="Apple-converted-space"> </span><br />
<b>E-mail:<span class="Apple-converted-space"> </span></b><a href="mailto:luigi.vaccaro@unipg.it" style="color: #014682; position: relative; text-decoration: none;" title="luigi.vaccaro@unipg.it">luigi.vaccaro@unipg.it</a><br />
<b>Web:<span class="Apple-converted-space"> </span></b>http://www.dcbb.unipg.it/greensoc</div>
<br />
Extra clips <img alt="" class="irc_mi i82N05uXUMwM-pQOPx8XEepE" src="http://www.wiley-vch.de/util/hottopics/img/ejic201501470.jpg" height="309" style="margin-top: 102px;" width="640" /><br />
<span class="_Hcb irc_iis"><a class="_Epb irc_tas i3598" data-noload="" data-ved="0ahUKEwi95s_YsY3NAhUhiKYKHT86BvQQjhwIBQ" href="https://www.google.co.in/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwi95s_YsY3NAhUhiKYKHT86BvQQjhwIBQ&url=http%3A%2F%2Fwww.wiley-vch.de%2Futil%2Fhottopics%2Fc-h-activation%2F&psig=AFQjCNHquppTzDOw-fw1Cza36bggHAVGVw&ust=1465095859157777" tabindex="0" target="_blank"><span class="irc_pt" dir="ltr" style="text-align: left;">C-H Activation :: Wiley-VCH Hot Topics</span></a></span><br />
<div class="irc_hd">
<span class="_r3"><a class="_ZR irc_hol i3724" data-noload="" data-ved="0ahUKEwi95s_YsY3NAhUhiKYKHT86BvQQjB0IBg" href="http://www.wiley-vch.de/util/hottopics/c-h-activation/" tabindex="0" target="_blank"><span class="irc_ho" dir="ltr">www.wiley-vch.de</span></a></span><span class="_r3 irc_msc"><a class="_ZR irc_msl i3591" data-i="1" data-noload="" data-ved="0ahUKEwi95s_YsY3NAhUhiKYKHT86BvQQhxwICA" href="https://www.google.co.in/search?tbs=simg%3Am00&tbnid=0NZRfXAGJAXUqM%3A&docid=Xq_wdFHLAib8NM&client=firefox-b&bih=589&biw=1366&tbm=isch" tabindex="0" target="_blank"><span class="irc_idim"></span></a></span></div>
<br />
<br />
<br />
<br />
<br />
<br />
<img alt="" class="irc_mi ip7mUvao2PIc-pQOPx8XEepE" src="http://www.scripps.edu/yu/yu_pub_images/mingshang-2014-acie.png" height="253" style="margin-top: 34px;" width="640" /><br />
<span class="_Hcb irc_iis"><a class="_Epb irc_tas i3598" data-noload="" data-ved="0ahUKEwixsInisY3NAhWk2aYKHf_bDZIQjhwIBQ" href="http://www.scripps.edu/yu/publications.php" tabindex="0" target="_blank"><span class="irc_pt" dir="ltr" style="text-align: left;">The Yu Lab</span></a></span><br />
<div class="irc_hd">
<span class="_r3"><a class="_ZR irc_hol i3724" data-noload="" data-ved="0ahUKEwixsInisY3NAhWk2aYKHf_bDZIQjB0IBg" href="http://www.scripps.edu/yu/publications.php" tabindex="0" target="_blank"><span class="irc_ho" dir="ltr">www.scripps.edu</span></a></span><span class="_r3 irc_sbc"><a class="_ZR irc_sbl i3592" data-i="1" data-noload="" data-ved="0ahUKEwixsInisY3NAhWk2aYKHf_bDZIQiBwICQ" href="https://www.google.co.in/search?tbs=sbi%3Acs&tbnid=GQm4L2JZhQFHfM%3A&docid=N7wX_C8bwVnPAM&client=firefox-b&bih=589&biw=1366" tabindex="0" target="_blank"></a></span><br />
<div class="irc_asc">
<span class="irc_su" dir="ltr" style="text-align: left;">"Ligand-Enabled
Triple C-H Activation Reactions: One-Pot Synthesis of Diverse
4-Aryl-2-quinolinones from Propionamides" Angew. Chem. Int. Ed. 2014,
53, ...</span></div>
</div>
<br />
////////////</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com1tag:blogger.com,1999:blog-81273127788638440.post-7146627201138618642016-05-07T18:47:00.002+05:302016-05-07T18:47:42.630+05:30N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis<div dir="ltr" style="text-align: left;" trbidi="on">
<h5 class="itemposttime">
<br /></h5>
<div class="itemcontent">
<div>
<img align="middle" class="" data-mce-src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6GC00932H" height="279" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6GC00932H" width="640" /></div>
<div>
<i><b>Green Chem.</b></i>, 2016, Advance Article<br /> <b>DOI</b>: 10.1039/C6GC00932H, Paper</div>
<div>
James Sherwood, Helen L. Parker, Kristof Moonen, Thomas J. Farmer, Andrew J. Hunt<br /> <em>N</em>-Butylpyrrolidinone (NBP) has been demonstrated as a suitable safer replacement solvent for <em>N</em>-Methylpyrrolidinone (NMP) in selected organic syntheses.</div>
</div>
<div>
<h4 class="itemtitle">
<a data-mce-href="http://feeds.rsc.org/~r/rss/GC/~3/YyGesvRxjLY/C6GC00932H" href="http://feeds.rsc.org/%7Er/rss/GC/%7E3/YyGesvRxjLY/C6GC00932H">N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis</a></h4>
</div>
<div>
<div class="article_chemsoc_txt_s13">
<h2 class="alpH1">
<em>N</em>-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis</h2>
</div>
<div class="peptide_wrap_s10_left">
<div class="peptide_middle">
<div>
<span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AJames%20Sherwood" href="http://pubs.rsc.org/en/results?searchtext=Author%3AJames%20Sherwood">James Sherwood</a>,<sup>a</sup> </span> <span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AHelen%20L.%20Parker" href="http://pubs.rsc.org/en/results?searchtext=Author%3AHelen%20L.%20Parker">Helen L. Parker</a>,<sup>a</sup> </span> <span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AKristof%20Moonen" href="http://pubs.rsc.org/en/results?searchtext=Author%3AKristof%20Moonen">Kristof Moonen</a>,<sup>b</sup> </span><span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AThomas%20J.%20Farmer" href="http://pubs.rsc.org/en/results?searchtext=Author%3AThomas%20J.%20Farmer">Thomas J. Farmer</a><sup>a</sup> and </span> <span class="author_link"><a data-mce-href="http://pubs.rsc.org/en/results?searchtext=Author%3AAndrew%20J.%20Hunt" href="http://pubs.rsc.org/en/results?searchtext=Author%3AAndrew%20J.%20Hunt">Andrew J. Hunt</a>*<sup>a</sup> </span></div>
<div class="show_affiliation_section" id="aff_info">
<div class="show_aff_content">
<div>
*Corresponding authors</div>
</div>
<div class="show_aff_content">
<div>
<sup class="affiliation_sup">a</sup>Green Chemistry Centre of Excellence, Department of Chemistry, University of York, UK<br /> <b>E-mail: </b><a data-mce-href="mailto:andrew.hunt@york.ac.uk" href="mailto:andrew.hunt@york.ac.uk" title="andrew.hunt@york.ac.uk">andrew.hunt@york.ac.uk</a></div>
</div>
<div class="show_aff_content">
<div>
<sup class="affiliation_sup">b</sup>Eastman Chemical Company, Pantserschipstraat 207 – B-9000, Gent, Belgium</div>
</div>
</div>
<div class="red_txt_s4">
<i><strong>Green Chem.</strong></i>, 2016, Advance Article</div>
<span class="DOILink"><strong>DOI: </strong>10.1039/C6GC00932H</span></div>
<div class="peptide_middle">
<a data-mce-href="http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00932H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract" href="http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00932H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#%21divAbstract">http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00932H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract</a></div>
</div>
</div>
<div class="peptide_middle">
</div>
<div>
Dipolar aprotic solvents such as <em>N</em>-methylpyrrolidinone
(or 1-methyl-2-pyrrolidone (NMP)) are under increasing pressure from
environmental regulation. NMP is a known reproductive toxin and has been
placed on the EU “Substances of Very High Concern” list. Accordingly
there is an urgent need for non-toxic alternatives to the dipolar
aprotic solvents. <em>N</em>-Butylpyrrolidinone, although structurally
similar to NMP, is not mutagenic or reprotoxic, yet retains many of the
characteristics of a dipolar aprotic solvent. This work introduces <em>N</em>-butylpyrrolidinone
as a new solvent for cross-coupling reactions and other syntheses
typically requiring a conventional dipolar aprotic solvent.</div>
<br />
<a data-mce-href="https://greenchemclips.files.wordpress.com/2016/05/str12.png" href="https://greenchemclips.files.wordpress.com/2016/05/str12.png"><img alt="str1" class="alignnone wp-image-592" data-mce-src="https://greenchemclips.files.wordpress.com/2016/05/str12.png?w=300" height="535" src="https://greenchemclips.files.wordpress.com/2016/05/str12.png?w=300" width="640" /></a><br />
<div>
<a data-mce-href="http://www.rsc.org/suppdata/c6/gc/c6gc00932h/c6gc00932h1.pdf" href="http://www.rsc.org/suppdata/c6/gc/c6gc00932h/c6gc00932h1.pdf">///</a>/N-Butylpyrrolidinone, dipolar aprotic solvent , organic synthesis</div>
</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com0tag:blogger.com,1999:blog-81273127788638440.post-12432191073842813112016-04-30T17:41:00.000+05:302016-04-30T17:47:54.667+05:30Dehydrogenative [2 + 2 + 1] Heteroannulation Using a Methyl Group as a One-Carbon Unit: Access to Pyrazolo[3,4-c]quinolines<div dir="ltr" style="text-align: left;" trbidi="on">
<h2>
<div class="art_title linkable">
<img alt="Figure" class="article-toc-graphic" src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/0/orlef7.ahead-of-print/acs.orglett.6b00618/20160428/images/medium/ol-2016-00618m_0006.gif" /></div>
<div class="art_title linkable">
</div>
<div class="art_title linkable">
<a href="http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b00618">Dehydrogenative [2 + 2 + 1] Heteroannulation Using a Methyl Group as a One-Carbon Unit: Access to Pyrazolo[3,4-<i>c</i>]quinolines</a></div>
</h2>
<h1 class="articleTitle">
<span class="hlFld-Title"></span></h1>
<div id="articleMeta">
<div id="authors">
<span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Deng%2C+Guo-Bo" id="authors">Guo-Bo Deng</a></span><span class="NLM_xref-aff"><sup>†</sup></span><span class="NLM_x">, </span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Li%2C+Hai-Bing" id="authors">Hai-Bing Li</a></span><span class="NLM_xref-aff"><sup>†</sup></span><span class="NLM_x">, </span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Yang%2C+Xu-Heng" id="authors">Xu-Heng Yang</a></span><span class="NLM_xref-aff"><sup>†</sup></span><span class="NLM_x">, </span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Song%2C+Ren-Jie" id="authors">Ren-Jie Song</a></span><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b00618#cor1"><sup>*</sup></a><span class="NLM_xref-aff"><sup>†</sup></span><span class="NLM_x">, </span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Hu%2C+Ming" id="authors">Ming Hu</a></span><span class="NLM_xref-aff"><sup>†</sup></span><span class="NLM_x">, and </span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Li%2C+Jin-Heng" id="authors">Jin-Heng Li</a></span><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b00618#cor2"><sup>*</sup></a><span class="NLM_xref-aff"><sup>†</sup></span><span class="NLM_xref-aff"><sup>‡</sup></span><span class="NLM_x"> </span></span></div>
<div class="affiliations">
<div id="aff1">
<sup>†</sup> State
Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry
and Chemical Engineering, <span class="institution">Hunan University</span>, Changsha 410082, <span class="country">China</span></div>
<div id="aff2">
<sup>‡</sup> State
Key Laboratory of Applied Organic Chemistry <span class="institution">Lanzhou University</span>, Lanzhou 730000, <span class="country">China</span></div>
</div>
<div id="citation">
<cite>Org. Lett.</cite>, Article ASAP</div>
<div id="doi">
<b>DOI: </b>10.1021/acs.orglett.6b00618</div>
<div id="pubDate">
Publication Date (Web): April 28, 2016</div>
<div id="artCopyright">
Copyright © 2016 American Chemical Society</div>
<div id="correspondence">
*E-mail: <a href="mailto:srj0731@hnu.edu.cn">srj0731@hnu.edu.cn</a>., *E-mail: <a href="mailto:jhli@hnu.edu.cn">jhli@hnu.edu.cn</a>.</div>
</div>
<div class="DOI">
<a href="http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b00618">http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b00618</a></div>
<div class="DOI">
</div>
<div class="DOI">
</div>
<div class="DOI">
A practical and straightforward access to pyrazolo[3,4-<i>c</i>]quinolines by molecular sieve mediated dehydrogenative [2 + 2 + 1] heteroannulation of <i>N</i>-(<i>o</i>-alkenylaryl)imines with aryldiazonium salts is described using a sp<sup>3</sup>-hybrid
carbon atom as a one-carbon unit. The reaction enables the formation of
three new chemical bonds, a C–C bond and two C–N bonds, in a single
reaction and features simple operation and excellent functional group
tolerance.</div>
<div class="DOI">
</div>
<div class="DOI">
</div>
<div class="DOI">
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-rURD5LY9fu0/VyShd0uGT9I/AAAAAAAASWY/zFEqLI9XN3g1rHxfH6i11QeeqSKaY1mSACLcB/s1600/str1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="346" src="https://1.bp.blogspot.com/-rURD5LY9fu0/VyShd0uGT9I/AAAAAAAASWY/zFEqLI9XN3g1rHxfH6i11QeeqSKaY1mSACLcB/s640/str1.jpg" width="640" /></a></div>
</div>
<div class="articleCheck">
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-qc8fGZSPfAY/VyShwlz8UlI/AAAAAAAASWc/5Gel8GHxm4c0iGOJTcc6-4gtAibP4U_dACLcB/s1600/str1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="372" src="https://1.bp.blogspot.com/-qc8fGZSPfAY/VyShwlz8UlI/AAAAAAAASWc/5Gel8GHxm4c0iGOJTcc6-4gtAibP4U_dACLcB/s640/str1.jpg" width="640" /></a></div>
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://4.bp.blogspot.com/-B1cF8Xrt8t4/VySh6SduOFI/AAAAAAAASWg/YvVXT1IEMWoZODvGd6ZD5K6xQ6TqPIOZQCLcB/s1600/str1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="410" src="https://4.bp.blogspot.com/-B1cF8Xrt8t4/VySh6SduOFI/AAAAAAAASWg/YvVXT1IEMWoZODvGd6ZD5K6xQ6TqPIOZQCLcB/s640/str1.jpg" width="640" /></a></div>
<a href="http://pubs.acs.org/doi/suppl/10.1021/acs.orglett.6b00618/suppl_file/ol6b00618_si_001.pdf">///////</a>//Dehydrogenative [2 + 2 + 1] Heteroannulation, Pyrazolo[3,4-<i>c</i>]quinolines</div>
</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com1tag:blogger.com,1999:blog-81273127788638440.post-58183217060476621262016-04-06T17:29:00.001+05:302016-04-06T17:29:43.321+05:30Continuous-Flow Process for the Synthesis of m-Nitrothioanisole<div dir="ltr" style="text-align: left;" trbidi="on">
<br />
<div id="abstractBox">
<div id="absImg">
<img alt="Abstract Image" src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/oprdfk/0/oprdfk.ahead-of-print/acs.oprd.6b00023/20160405/images/medium/op-2016-00023d_0014.gif" /></div>
<div class="articleBody_abstractText">
A continuous-flow process for the preparation of <i>m</i>-nitrothioanisole has been set up. The starting material <i>m</i>-nitroaniline
was diazotized to give diazonium chloride, followed by azo-coupling
with sodium thiomethoxide to give
1-(methylthio)-2-(3-nitrophenyl)diazene, then dediazoniated to gain <i>m</i>-nitrothioanisole
in high yield. The continuous-flow process minimized accumulation of
the energetic intermediate diazonium salt and has a better capacity for
adapting large-scale production. A solvent was introduced in the
azo-coupling section to create a biphasic flow system. Side products
were inhibited eminently in this flow process.</div>
</div>
<br />
<br />
<div class="widget layout-two-columns none article-type-and-nav widget-none widget-compact-all" id="c19b0f7c-22ac-42b9-8bcf-dad150505eb2">
<div class="wrapped ">
<div class="widget-body body body-none body-compact-all">
<div class="pb-columns row-fluid gutterless">
<div class="widget general-html none widget-none widget-compact-all" id="7efd1d6e-21a6-48c5-8b37-77cf7a915c9a">
<div class="wrapped ">
</div>
</div>
<div class="width_1_2">
<br />
</div>
</div>
</div>
</div>
</div>
<h1 class="articleTitle">
<span class="hlFld-Title">Continuous-Flow Process for the Synthesis of <i>m</i>-Nitrothioanisole</span></h1>
<div id="articleMeta">
<div id="authors">
<span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Yu%2C+Zhiqun" id="authors">Zhiqun Yu</a></span><span><span class="NLM_xref-aff"><sup>†</sup></span></span><span><span class="NLM_x">, </span></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Xie%2C+Xiaoxuan" id="authors">Xiaoxuan Xie</a></span><span><span class="NLM_xref-aff"><sup>†</sup></span></span><span><span class="NLM_x">, </span></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Dong%2C+Hei" id="authors">Hei Dong</a></span><span><span class="NLM_xref-aff"><sup>†</sup></span></span><span><span class="NLM_x">, </span></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Liu%2C+Jiming" id="authors">Jiming Liu</a></span><span><span class="NLM_xref-aff"><sup>‡</sup></span></span><span><span class="NLM_x">, and </span></span></span><span class="hlFld-ContribAuthor"><span class="hlFld-ContribAuthor"><a href="http://pubs.acs.org/author/Su%2C+Weike" id="authors">Weike Su</a></span><span><a class="ref" href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00023#cor1"><sup>*</sup></a></span><span><span class="NLM_xref-aff"><sup>†</sup></span></span><span><span class="NLM_xref-aff"><sup>‡</sup></span></span><span><span class="NLM_x"> </span></span></span></div>
<div class="affiliations">
<div id="aff1">
<sup>†</sup> National
Engineering Research Center for Process Development of Active Pharmaceutical
Ingredients, Collaborative Innovation Center of Yangtze River Delta
Region Green Pharmaceuticals, <span class="institution">Zhejiang University
of Technology</span>, Hangzhou 310014, <span class="country">P. R. China</span></div>
<div id="aff2">
<sup>‡</sup> Key
Laboratory for Green Pharmaceutical Technologies and Related Equipment
of Ministry of Education, College of Pharmaceutical Sciences, <span class="institution">Zhejiang University of Technology</span>, Hangzhou 310014, <span class="country">P. R. China</span></div>
</div>
<div id="citation">
<cite>Org. Process Res. Dev.</cite>, Article ASAP</div>
<div id="doi">
<strong>DOI: </strong>10.1021/acs.oprd.6b00023</div>
<div id="pubDate">
Publication Date (Web): March 24, 2016</div>
<div id="artCopyright">
Copyright © 2016 American Chemical Society</div>
<div id="correspondence">
*Tel.: <span class="phone">(+86)57188320899</span>. E-mail: <a href="mailto:pharmlab@zjut.edu.cn">pharmlab@zjut.edu.cn</a>.</div>
</div>
<a href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00023">http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00023</a><br />
////////</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com0tag:blogger.com,1999:blog-81273127788638440.post-66747998532869094442016-03-21T12:30:00.000+05:302016-03-21T12:52:33.850+05:30Eco-friendly construction of highly functionalized chromenopyridinones by an organocatalyzed solid-state melt reaction and their optical properties<div dir="ltr" style="text-align: left;" trbidi="on">
<br />
<h4 class="itemtitle" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 18px; letter-spacing: -0.25px; margin: 0px; padding: 0px;">
</h4>
<h5 class="itemposttime" style="background-color: #dddddd; color: #666666; font-family: Helvetica, Arial, sans-serif; font-size: 14px; font-weight: normal; margin: 3px 0px 6px; padding: 0px;">
</h5>
<div class="itemcontent" name="decodeable" style="background-color: #dddddd; font-family: Helvetica, Arial, sans-serif; font-size: 14px; line-height: 18.2000007629395px; overflow: hidden; width: 693px;">
<div>
<div style="margin-bottom: 1em; padding: 0px;">
<img align="center" src="http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C5GC02658J" height="284" width="640" /></div>
</div>
<div>
<i><b>Green Chem.</b></i>, 2016, <b>18</b>,1488-1494<br />
<b>DOI</b>: 10.1039/C5GC02658J, Paper</div>
<div>
Sanjay Paul, Yong Rok Lee<br />
Diverse chromenopyridinone derivatives were synthesized under organocatalytic solid-state melt conditions. The optical properties of these [small pi]-expanded chromenopyridine derivatives were examined.<br />
The content of this RSS Feed (c) The Royal Society of Chemistry</div>
<div>
<h4 class="itemtitle" style="font-size: 18px; letter-spacing: -0.25px; line-height: normal; margin: 0px; padding: 0px;">
<a href="http://feeds.rsc.org/~r/rss/GC/~3/ZuQygtKrgHQ/C5GC02658J" style="color: #000099; text-decoration: none;">Eco-friendly construction of highly functionalized chromenopyridinones by an organocatalyzed solid-state melt reaction and their optical properties</a></h4>
</div>
</div>
<br />
<br />
<a href="http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C5GC02658J?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract">http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C5GC02658J?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract</a><br />
<br />
<div class="article_chemsoc_txt_s13" style="background-color: white; color: #003c73; float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px; margin-bottom: 5px; padding-left: 10px; padding-right: 10px; width: 520px;">
<h2 class="alpH1" style="float: left; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 21px; margin: 0px; padding: 0px;">
Eco-friendly construction of highly functionalized chromenopyridinones by an organocatalyzed solid-state melt reaction and their optical properties</h2>
</div>
<div class="peptide_wrap_s10_left" style="background-color: white; float: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; height: auto; line-height: 16px; padding-left: 10px; padding-top: 5px; width: 370px;">
<div class="peptide_middle" style="float: left; line-height: 20px; width: 360px;">
<div>
<span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3ASanjay%20Paul" style="color: black;">Sanjay Paul</a><sup>a</sup> and </span> <span class="author_link" style="display: inline-block; margin-right: -3px; padding: 0px; position: relative;"><a href="http://pubs.rsc.org/en/results?searchtext=Author%3AYong%20Rok%20Lee" style="color: black;">Yong Rok Lee</a><span style="font-size: 16px;">*</span><sup>a</sup> </span></div>
<div style="clear: left;">
</div>
<div class="show_aff" style="margin: 5px 0px 4px;">
</div>
<div class="show_affiliation_section" id="aff_info" style="background-color: #eef1f6; float: left; margin-bottom: 5px; padding: 0px 3px 10px 5px; width: 360px;">
<div>
<a aria-describedby="aff_info" class="show_hide_affiliation" href="http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C5GC02658J?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#" id="hideAffiliation" style="color: #014682; cursor: pointer; text-decoration: none;">Hide Affiliations</a></div>
<div class="show_aff_content" style="padding-top: 5px; width: 360px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
*</div>
<div style="padding-left: 10px;">
Corresponding authors</div>
</div>
<div class="show_aff_content" style="padding-top: 5px; width: 360px;">
<div class="show_affiliation" style="float: left; font-style: italic; padding-right: 5px; width: 7px;">
<sup class="affiliation_sup" style="position: relative; top: -4px;">a</sup></div>
<div style="padding-left: 10px;">
School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea<br />
<b>E-mail: </b><a href="mailto:yrlee@yu.ac.kr" style="color: #014682; text-decoration: none;" title="yrlee@yu.ac.kr">yrlee@yu.ac.kr</a><br />
<b>Fax: </b>+82-53-810-4631<br />
<b>Tel: </b>+82-53-810-2529</div>
</div>
</div>
<div class="red_txt_s4" style="float: left; line-height: 18px; width: 360px;">
<i><strong>Green Chem.</strong></i>, 2016,<span style="padding-right: 2px;"></span><strong>18</strong>, 1488-1494</div>
<br />
<span class="DOILink" style="float: left; padding: 0px; width: 505px;"><strong>DOI: </strong>10.1039/C5GC02658J</span></div>
</div>
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<span style="background-color: white; color: #222222; font-family: "arial"; font-size: 12px; line-height: 18px;">The library construction of highly functionalized and diverse chromenopyridinones was achieved by three-component reactions of various 4-hydroxycoumarins with ammonium acetate and 3-formylchromones under </span><small style="background-color: white; color: #222222; font-family: Arial; line-height: 18px;">L</small><span style="background-color: white; color: #222222; font-family: "arial"; font-size: 12px; line-height: 18px;">-proline catalyzed solid-state melt conditions. The advantages of this protocol include the use of an inexpensive organocatalyst, avoidance of toxic organic solvents, environmentally benign conditions, an easy work-up procedure and good to excellent product yields. The optical properties of these π-expanded varieties of the synthesized chromenopyridinone derivatives were also examined. A chromeno[4,3-</span><em style="background-color: white; color: #222222; font-family: Arial; font-size: 12px; line-height: 18px;">b</em><span style="background-color: white; color: #222222; font-family: "arial"; font-size: 12px; line-height: 18px;">]pyridine nucleus bearing an electron donating group exhibited strong emission in the blue-green region of the visible spectrum.</span><br />
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://2.bp.blogspot.com/-YBJg3_Ul3lo/Vu-bWmbM5FI/AAAAAAAASMM/SDiQjXPpbRgUnQA7c0wBUHyBVRYSJ48Cg/s1600/str1.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="460" src="https://2.bp.blogspot.com/-YBJg3_Ul3lo/Vu-bWmbM5FI/AAAAAAAASMM/SDiQjXPpbRgUnQA7c0wBUHyBVRYSJ48Cg/s640/str1.png" width="640" /></a></div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-PXIoW16ko1A/Vu-gqPR0ubI/AAAAAAAASMc/qDvecQ4woYgNsPnRxhtgaiiVjgRuvzE4w/s1600/str1.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="386" src="https://3.bp.blogspot.com/-PXIoW16ko1A/Vu-gqPR0ubI/AAAAAAAASMc/qDvecQ4woYgNsPnRxhtgaiiVjgRuvzE4w/s640/str1.png" width="640" /></a></div>
<br />
<br />
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://3.bp.blogspot.com/-sQHUlVT9E2g/Vu-g0HLtX1I/AAAAAAAASMg/lxfL-DmZzt05JqLkpdVpeslAuVDv4ymLg/s1600/str1.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="380" src="https://3.bp.blogspot.com/-sQHUlVT9E2g/Vu-g0HLtX1I/AAAAAAAASMg/lxfL-DmZzt05JqLkpdVpeslAuVDv4ymLg/s640/str1.png" width="640" /></a></div>
<br />
<br />
<br />
<a href="http://www.rsc.org/suppdata/c5/gc/c5gc02658j/c5gc02658j1.pdf">///</a>/////</div>
DRUG PATENTS INTERNATIONALhttp://www.blogger.com/profile/12652768774396889936noreply@blogger.com1