Weygand/Hilgetag Preparative Organic Chemistry
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Thursday 19 September 2013
Weygand/Hilgetag Preparative Organic Chemistry
Sunday 15 September 2013
Monday 9 September 2013
Antioxidant Mechanism of Active Ingredients Separated from Eucalyptus globulus
Antioxidant Mechanism of Active Ingredients Separated from Eucalyptus globulus | |||
N. M. El-Moein, E. A. Mahmoud and Emad A. Shalaby* | |||
Biochemistry Department, Faculty of Agriculture, Cairo University, Giza, Egypt, 12613 | |||
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OMICS Publishing Group | Full-text | Antioxidant Mechanism of Active Ingredients Separated from Eucalyptus globulus:
'via Blog this'
Sunday 8 September 2013
Friday 6 September 2013
Fullerenols: Fulfilling our Future Energy Needs
Carbon to catalyze low-carbon, hydrogen economy
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Sunday 1 September 2013
Synthesis of Tolvaptan
Synthesis of Tolvaptan
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YANG Chuanwei~1,MU Shuai~2,LIU Ying~3,WANG Pingbao~3,LIU Dengke~(3*)
(1.School of Pharmacy,Henan University,Kaifeng 475004;2.
School of Chemical Engineering and Technology,
Tianjin University,Tianjin 300072;3.
Tianjin Institute of Pharmaceutical Research,Tianjin 300193)
(1.School of Pharmacy,Henan University,Kaifeng 475004;2.
School of Chemical Engineering and Technology,
Tianjin University,Tianjin 300072;3.
Tianjin Institute of Pharmaceutical Research,Tianjin 300193)
Tolvaptan,a selective nonpeptide arginine vasopressin V_2 receptor antagonist,was synthesized
from 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine by acylation and reduction to give 1-(4-amino-2-methylbenzoyl) -7- chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine,which was subjected to acylation with 2-methylbenzoyl chloride and reduction with sodium borohydride with an overall yield of about 45%.
from 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine by acylation and reduction to give 1-(4-amino-2-methylbenzoyl) -7- chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine,which was subjected to acylation with 2-methylbenzoyl chloride and reduction with sodium borohydride with an overall yield of about 45%.
【Key Words】: tolvaptan arginine vasopressin V_2 receptor antagonist heart failure hyponatremia synthesis
【Fund】: 天津市科技计划项目(09ZCKFSH01300)
【CateGory Index】: R914
【Fund】: 天津市科技计划项目(09ZCKFSH01300)
【CateGory Index】: R914
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