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Wednesday, 7 August 2013

A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide

Graphical abstract: A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide
A method for the synthesis of α-amino acids by direct reductive carboxylation of aromatic imines with CO2 is described. The protocol employs readily available commercial reagents and serves as a one-step alternative to the Strecker synthesis.

A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide


* Corresponding authors
a
Department of Chemistry, The Pennsylvania State University, University Park, USA 
E-mail: radosevich@psu.edu ;
Tel: +1 814 867 4268
Chem. Commun., 2013,49, 5040-5042

DOI: 10.1039/C3CC42057D
Received 21 Mar 2013, Accepted 16 Apr 2013
First published online 25 Apr 2013

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