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Showing posts with label 2-nitroanilines. Show all posts
Showing posts with label 2-nitroanilines. Show all posts

Saturday 19 April 2014

Au catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO2/H2




Green Chem., 2014, Advance Article
DOI: 10.1039/C4GC00153B, Paper
Leiduan Hao, Yanfei Zhao, Bo Yu, Hongye Zhang, Huanjun Xu, Zhimin Liu
The gold-catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO2 in the presence of H2 was reported, and a series of benzimidazoles were obtained under relatively mild conditions.


The gold-catalyzed synthesis of benzimidazoles from 2-nitroanilines and CO2 in the presence of
 H2 was reported, and a series of benzimidazoles were obtained under relatively mild conditions. 
Several supported Au catalysts including Au/TiO2, Au/Al2O3, Au/ZnO, Au/polyurea and Au/hydrotalcite
 were examined for the synthesis of benzimidazole from the reaction of 2-nitroaniline with CO2 and H2
among which Au/TiO2 displayed the best performance. The reaction mechanism was investigated, 
and it was found that the production of benzimidazole underwent the formation of o-phenylenediamine 
via the hydrogenation of 2-nitroaniline, followed by the cyclization of o-phenylenediamine with CO2 and H2
This work provides a CO2-involved route for the synthesis of benzimidazoles, 
which may widen the applications of CO2 in the chemical synthesis.