Multicomponent Multicatalyst Reactions (MC)2R:  One-Pot Synthesis of 3,4-Dihydroquinolinones Lei Zhang, Lorenzo Sonaglia, Jason Stacey, and Mark Lautens Org. Lett. 2013, 15, 2128-2131. DOI:10.1021/ol4006008 . A Rh/Pd/Cu catalyst system led to an efficient synthesis of dihydroquinolinones in one-pot, two operations. The reaction features the first triple metal-catalyzed transformations in one reaction vessel, without any intermediate workup. The conjugate-addition/amidation/amidation reaction sequence is highly modular, divergent, and practical. Multicomponent Multicatalyst Reactions (MC)2R: One-Pot Synthesis of 3,4-Dihydroquinolinones Lei Zhang, Lorenzo Sonaglia, Jason Stacey, and Mark Lautens* Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario M5S 3H6, Canada Org. Lett., 2013, 15 (9), pp 2128–2131 DOI: 10.1021/ol4006008 Publication Date (Web): April 19, 2013 Copyright © 2013 American Chemical Society mlautens@chem.utoronto.ca http://pubs.acs.org/doi/abs/10.1021/ol4006008 Mark Lautens Mark Lautens , O.C. University Professor J. Bryan Jones Distinguished Professor AstraZeneca Professor of Organic Chemistry NSERC/Merck-Frosst Industrial Research Chair Department of Chemistry Davenport Chemical Laboratories 80 St. George St. University of Toronto Toronto, Ontario M5S 3H6 Tel: (416) 978-6083 Fax: (416) 946-8185 E-Mail: mlautens@chem.utoronto.ca Curriculum Vitae Personal Place and Date of Birth Hamilton, Ontario, Canada July 9, 1959 Education Harvard University NSERC PDF with D. A. Evans 1985 - 1987 University of Wisconsin-Madison Ph.D. with B. M. Trost 1985 University of Guelph B.Sc. - Distinction 1981 Academic Positions J. Bryan Jones Distinguished Professor University of Toronto 2013 - 2018 University Professor University of Toronto 2012 - present NSERC/Merck Frosst Industrial Research Chair NSERC/Merck Frosst 2003 - 2013 AstraZeneca Professor of Organic Synthesis University of Toronto 1998 - present Professor University of Toronto 1995 - 1998 Associate Professor University of Toronto 1992 - 1995 Assistant Professor University of Toronto 1987 - 1992 Awards & Honors University of Toronto Alumni Faculty Award University of Toronto 2016 CIC Catalysis Award CSC 2016 Officer of the Order of Canada Governor General 2014 Killam Research Fellowship Canada Council for the Arts 2013-2015 CIC Medal Chemical Institute of Canada 2013 Fellow of the Royal Society of UK Royal Society of Chemistry 2011 Pedler Award Royal Society of Chemistry 2011 Senior Scientist Award Alexander von Humboldt Foundation Berlin, Aachen and Gottingen 2009-2014 Visiting Professor University of Berlin 2009 Visiting Professor Université de Marseilles 2008 ICIQ Summer School ICIQ Tarragona, Spain 2008 Attilio Corbella Summer School Professor Italian Chemical Society 2007 Arthur C. Cope Scholar Award American Chemical Society 2006 Alfred Bader Award Canadian Society for Chemistry 2006 R. U. Lemieux Award Canadian Society for Chemistry 2004 Solvias Prize Solvias AG 2002 Fellow of the Royal Society of Canada Royal Society of Canada 2001 Areas of Research Interest and Expertise new synthetic methods metal catalyzed cycloaddition and annulation reactions asymmetric catalysis with focus on rhodium, nickel and palladium catalysts cyclopropane synthesis and reactions hydrometallation reactions reactions of organosilicon and organotin compounds fragmentation reactions new routes to medicinally/biologically interesting compounds heterocycle synthesis using metal catalysts ////////////