† State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
‡ State Key Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000, China
Org. Lett., Article ASAP
Publication Date (Web): April 28, 2016
Copyright © 2016 American Chemical Society
A practical and straightforward access to pyrazolo[3,4-c]quinolines by molecular sieve mediated dehydrogenative [2 + 2 + 1] heteroannulation of N-(o-alkenylaryl)imines with aryldiazonium salts is described using a sp3-hybrid carbon atom as a one-carbon unit. The reaction enables the formation of three new chemical bonds, a C–C bond and two C–N bonds, in a single reaction and features simple operation and excellent functional group tolerance.
/////////Dehydrogenative [2 + 2 + 1] Heteroannulation, Pyrazolo[3,4-c]quinolines