DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 30 Yrs Exp. in the feld of Organic Chemistry. Serving chemists around the world. Helping them with websites on Chemistry.Millions of hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
n

Tuesday 17 June 2014

Altering physical properties of pharmaceutical co-crystals in a systematic manner

 Graphical abstract: Altering physical properties of pharmaceutical co-crystals in a systematic manner
 
Christer B. Aakeröy, Safiyyah Forbes and John Desper
CrystEngComm, 2014, 16, 5870 DOI:10.1039/C4CE00206G
 
Systematic structure–property studies on a series of co-crystals of potential cancer drugs with aliphatic dicarboxylic acids were undertaken. This study reveals that systematic changes to the molecular nature of the co-crystallizing agent combined with control over the way individual building blocks are organized within the crystalline lattice makes it possible to establish predictable links between molecular structure and macroscopic physical properties, such as melting behaviour and aqueous solubility. However, it is not possible to find any notable correlation between physical properties and chemical compositions in the absence of structural consistency.

Paper

Altering physical properties of pharmaceutical co-crystals in a systematic manner

*Corresponding authors
aDepartment of Chemistry, Kansas State University, 213 CBC Building, Manhattan, USA
E-mail: aakeroy@ksu.edu;
Fax: +1 785 532 6666 ;
Tel: +1 785 532 6096
CrystEngComm, 2014,16, 5870-5877

DOI: 10.1039/C4CE00206G

No comments:

Post a Comment