Larvicidal isoxazoles: Synthesis and their effective susceptibility towards Aedes aegypti larvae

................

Larvicidal isoxazoles: Synthesis and their effective susceptibility towards Aedes aegypti larvae

 
 

Bioorganic & Medicinal Chemistry

Volume 21, Issue 4, 15 February 2013, Pages 940–947

Diana C.B. da Silva-Alves, Janaína V. dos Anjos, Nery N.M. Cavalcante, Geanne K.N. Santos, Daniela M.do A.F. Navarro, Rajendra M. Srivastava

 Twenty 3,5-disubstituted isoxazoles have been synthesized and tested against fourth instar Aedes aegyptilarvae. In the synthesis of title compounds, modifications have been made in the C-5 side-chain with a view to test their larvicidal activity. These isoxazoles have been obtained by 1,3-dipolar cycloaddition of arylnitrile oxides to terminal alkynes which furnished the desired products in 20% to 79% yields. A comparative study of the larvicidal activity between 3-(3-aryl-isoxazol-5-yl)-propan-1-ols and 3-(3-aryl-isoxazol-5-yl)-propionic acids clearly demonstrated that the latter compounds possess much better larvicidal activity than the former. We also tested two esters, viz., methyl 3-[3-(phenyl)-isoxazole-5-yl] propionate and methyl 3-[3-(4-chlorophenyl)-isoxazole-5-yl] propionate, where the latter presented an excellent larvicidal profile.

The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective « New Drug Approvals

The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective « New Drug Approvals:



'via Blog this'

The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective « New Drug Approvals

The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective « New Drug Approvals:



'via Blog this'

Catalyst Under Stress

 
The oxidation of water to molecular oxygen is an important reaction in the frame of artificial photosynthesis, solar fuels, and a sustainable energy future. Iridium complexes have recently gained attention as effective precatalysts for this transformation. 

To gain deeper understanding of this process, Alceo Macchioni, University of Perugia, Italy, and colleagues aimed at intercepting the intermediates of the oxidative transformation of [Cp*Ir(bzpy)NO₃] (Cp* = pentamethylcyclopentadienyl, bzpy = 2-benzoylpyridine), which is a competent catalyst for water oxidation.
read at
http://www.chemistryviews.org/details/ezine/5838331/Catalyst_Under_Stress.html

Make a macroring in half a day instead of several months

Make a macroring in half a day instead of several months. 

INTRODUCTION

Macrocycles are not only esthetically pleasing, but they also can contain multiple functional groups. They are, however, difficult to synthesize. For example, preparing sterically crowded, circularly folded aromatic pentamer 1 required a months-long step-by-step process; and it was obtained in an overall yield of only ≈5%

(Qin, B., et al. Org. Lett. 2008, 10, 5127–5130).

The task is much easier now; it can be accomplished in half a day by using a synthetic route developed by H. Zeng and coauthors at the National University of Singapore, Guang Dong University of Technology (China), and Nanyang Technological University (Singapore).

 One-pot, multi-molecular macrocyclization allows the highly selective preparation of pentagon-shaped circular aromatic pentamers mediated by an inward-pointing continuous hydrogen-bonding network.

The protocol is based on a hydrogen-bonding–assisted, one-pot macrocyclization reaction. In the presence of coupling reagent POCl3 and organic base Et3N, 3-amino-2-methoxybenzoic acid (2) undergoes self-amidation under mild conditions to give 1 in a high yield (46%) after a 12-h reaction time. The versatility of this highly selective macrocyclization reaction is illustrated by synthesizing derivatives of 2 with various substituents at the 2- and 5-positions. (Chem. Commun. 2011, 47, 5419–5421;

 http://pubs.rsc.org/en/content/articlelanding/2011/CC/C0CC05791F#!divAbstract

--

THANKS AND REGARD'S
DR ANTHONY MELVIN CRASTO Ph.D

amcrasto@gmail.com

MOBILE-+91 9323115463

GLENMARK SCIENTIST ,  INDIA
web link

ABOUTME

BRAND ANTHONYCRASTO

COLLECTION OF SITE LINKS

http://amcrasto.bravesites.com/

http://anthonycrasto.jimdo.com/

Congratulations! Your presentation titled "Anthony Crasto Glenmark scientist, helping millions with websites" has just crossed MILLION views.

アンソニー     安东尼   Энтони    안토니     أنتوني

join my process development group on google

organic-process-development group

you can post articles and will be administered by me on the google group which is very popular across the world

https://sites.google.com/site/amcrasto/

SKILLPAGES

MIXXT

APNACIRCLE

LinkedIn group

SYNTHETIC ORGANIC CHEMISTRY

 
blogs are 

• Green Chemistry International,  
• Eurekamoments in Organic Chemistry ,   
• WIX CHEMISTRY BLOG , 
• Drug regulatory affairs international 
• ORGANIC CHEMISTRY SELECT
• ORGANIC SPECTROSCOPY INTERNATIONAL 
• ORGANIC SYNTHESIS INTERNATIONAL 
• ORGANIC CHEMISTRY INTERNATIONAL

MY BLOG ON MED CHEM

New Drug Approvals

ALL ABOUT DRUGS

WORLD DRUG TRACKER

MEDICINAL CHEM INTERNATIONAL

DRUG SYN INTERNATIONAL

SCALEUP OF DRUGS

ALL FOR DRUGS ON WEB

http://scholar.google.co.uk/citations?user=bxm3kYkAAAAJ

Detecting Thrombosis

A magnetic resonance (MR) probe can be used to distinguish old and new blood clots

Read more

Studies of Removal of Indigo Caramine Dye from Water by Formaldehyde and Urea Treated Cellulosic Waste of Citrus reticulata Peels

 Citrus reticulata, Orange


Studies of Removal of Indigo Caramine Dye from Water by Formaldehyde and Urea Treated Cellulosic Waste of Citrus reticulata Peels



Asian J. Chem., 2014, 26(1), pp 43-47   |  DOI:10.14233/ajchem.2014.15305

Rabia Rehman*, Javaria Zafar and Hina Nisar

Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan

*Corresponding author: Fax: +92 42 99230998; 

Tel: +92 42 99230463, Ext: 870; E-mail: grinorganic@yahoo.com

The Citrus reticulata (orange) peels has been employed as adsorbents for removing inorganic and organic pollutants from wastewater extensively due to its low cost and eco-friendly nature. This research work concerns with the study of comparative removal of Indigo carmine dye from water using simple, formaldehyde and urea treated Citrus reticulata peels. The effect of adsorption parameters were investigated and maximum sorption capacity was obtained from Langmuir isotherm model at optimized conditions, i.e.: 5.90, 14.79 and 71.07 mg g-1 for simple, formaldehyde treated and urea treated Citrus reticulata peels, respectively. 

Feasibility of process is indicated by the values of separation factor, Gibb’s free energy and adsorption intensity ‘n’. The results of present study indicate that Citrus reticulata peels has inherited a lots of capacity for removing anthraquinone type of dyes, which can be further improved by treating with formaldehyde or urea in economical way.

View Article 

http://www.asianjournalofchemistry.co.in/User/ViewFreeArticle.aspx?ArticleID=26_2_12

Asian Journal of Chemistry

AN INTERNATIONAL PEER REVIEWED RESEARCH JOURNAL OF CHEMISTRY

Inst of Chem Eng , Univ of punjab, Pakistan




OLD CAMPUS
http://www.pu.edu.pk/



INST OF CHEMISTRY, UNIV OF PUNJAB LAHORE PAKISTAN




University of the Punjab, Lahore, Pakistan-54590


LAHORE AT NIGHT


LAHORE FOOD STREET