Drug Patents International

Drug Patents International:



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New Pentafluorosulfanyls

New Pentafluorosulfanyls

Transformation of an existing heterocyclic sulfur functionality to prepare SF5-substituted heterocycles
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 http://www.chemistryviews.org/details/ezine/6924381/New_Pentafluorosulfanyls.html

Formal Total Synthesis of (–)-Taxol

Formal Total Synthesis of (–)-Taxol

Pd-catalyzed eight-membered carbocyclic ring formation
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http://www.chemistryviews.org/details/ezine/6898421/Formal_Total_Synthesis_of_-Taxol.html

Telling Solvents Apart the Easy Way

Telling Solvents Apart the Easy Way

Help could be soon on hand for the horrible moment of thinking "What solvent did I just add to that reaction?"
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 http://www.chemistryviews.org/details/ezine/6830971/Telling_Solvents_Apart_the_Easy_Way.html

Catalytic Nitration of Anilines

Catalytic Nitration of Anilines

A copper-catalyzed mild nitration of protected anilines
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 http://www.chemistryviews.org/details/ezine/6712381/Catalytic_Nitration_of_Anilines.html

Solid Approach to Product Extraction

An effective solid-extraction method to simplify the workup of organic reactions
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 http://www.chemistryviews.org/details/news/6835901/Solid_Approach_to_Product_Extraction.html

A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly

 A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly 
I.R. Baxendale, J. Deeley, C.M. Griffiths-Jones, S.V. Ley, S. Saaby and G. Tranmer, J. Chem. Soc., Chem. Commun. 2006, 2566-2568.
http://pubs.rsc.org/en/Content/ArticleLanding/2006/CC/b600382f#!divAbstract 


 

A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalysts, scavengers or catch and release agents; our route involves the combination of seven separate synthetic steps linked into one continuous sequence utilizing flow chemistry.