The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective « New Drug Approvals

The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective « New Drug Approvals:



'via Blog this'

The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective « New Drug Approvals

The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective « New Drug Approvals:



'via Blog this'

Catalyst Under Stress

 
The oxidation of water to molecular oxygen is an important reaction in the frame of artificial photosynthesis, solar fuels, and a sustainable energy future. Iridium complexes have recently gained attention as effective precatalysts for this transformation. 

To gain deeper understanding of this process, Alceo Macchioni, University of Perugia, Italy, and colleagues aimed at intercepting the intermediates of the oxidative transformation of [Cp*Ir(bzpy)NO₃] (Cp* = pentamethylcyclopentadienyl, bzpy = 2-benzoylpyridine), which is a competent catalyst for water oxidation.
read at
http://www.chemistryviews.org/details/ezine/5838331/Catalyst_Under_Stress.html

Make a macroring in half a day instead of several months

Make a macroring in half a day instead of several months. 

INTRODUCTION

Macrocycles are not only esthetically pleasing, but they also can contain multiple functional groups. They are, however, difficult to synthesize. For example, preparing sterically crowded, circularly folded aromatic pentamer 1 required a months-long step-by-step process; and it was obtained in an overall yield of only ≈5%

(Qin, B., et al. Org. Lett. 2008, 10, 5127–5130).

The task is much easier now; it can be accomplished in half a day by using a synthetic route developed by H. Zeng and coauthors at the National University of Singapore, Guang Dong University of Technology (China), and Nanyang Technological University (Singapore).

 One-pot, multi-molecular macrocyclization allows the highly selective preparation of pentagon-shaped circular aromatic pentamers mediated by an inward-pointing continuous hydrogen-bonding network.

The protocol is based on a hydrogen-bonding–assisted, one-pot macrocyclization reaction. In the presence of coupling reagent POCl3 and organic base Et3N, 3-amino-2-methoxybenzoic acid (2) undergoes self-amidation under mild conditions to give 1 in a high yield (46%) after a 12-h reaction time. The versatility of this highly selective macrocyclization reaction is illustrated by synthesizing derivatives of 2 with various substituents at the 2- and 5-positions. (Chem. Commun. 2011, 47, 5419–5421;

 http://pubs.rsc.org/en/content/articlelanding/2011/CC/C0CC05791F#!divAbstract

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Detecting Thrombosis

A magnetic resonance (MR) probe can be used to distinguish old and new blood clots

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Studies of Removal of Indigo Caramine Dye from Water by Formaldehyde and Urea Treated Cellulosic Waste of Citrus reticulata Peels

 Citrus reticulata, Orange


Studies of Removal of Indigo Caramine Dye from Water by Formaldehyde and Urea Treated Cellulosic Waste of Citrus reticulata Peels



Asian J. Chem., 2014, 26(1), pp 43-47   |  DOI:10.14233/ajchem.2014.15305

Rabia Rehman*, Javaria Zafar and Hina Nisar

Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan

*Corresponding author: Fax: +92 42 99230998; 

Tel: +92 42 99230463, Ext: 870; E-mail: grinorganic@yahoo.com

The Citrus reticulata (orange) peels has been employed as adsorbents for removing inorganic and organic pollutants from wastewater extensively due to its low cost and eco-friendly nature. This research work concerns with the study of comparative removal of Indigo carmine dye from water using simple, formaldehyde and urea treated Citrus reticulata peels. The effect of adsorption parameters were investigated and maximum sorption capacity was obtained from Langmuir isotherm model at optimized conditions, i.e.: 5.90, 14.79 and 71.07 mg g-1 for simple, formaldehyde treated and urea treated Citrus reticulata peels, respectively. 

Feasibility of process is indicated by the values of separation factor, Gibb’s free energy and adsorption intensity ‘n’. The results of present study indicate that Citrus reticulata peels has inherited a lots of capacity for removing anthraquinone type of dyes, which can be further improved by treating with formaldehyde or urea in economical way.

View Article 

http://www.asianjournalofchemistry.co.in/User/ViewFreeArticle.aspx?ArticleID=26_2_12

Asian Journal of Chemistry

AN INTERNATIONAL PEER REVIEWED RESEARCH JOURNAL OF CHEMISTRY

Inst of Chem Eng , Univ of punjab, Pakistan




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Natural product based leads to fight against leishmaniasis

The growing incidence of parasitic resistance against generic pentavalent antimonials, specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania control. Notwithstanding the two treatment alternatives, that is amphotericin B and miltefosine are being effectively used but their high cost and therapeutic complications limit their use in endemic areas. In the absence of a vaccine candidate, identification, and characterization of novel drugs and targets is a major requirement of leishmanial research. This review describes current drug regimens, putative drug targets, numerous natural products that have shown promising antileishmanial activity alongwith some key issues and strategies for future research to control leishmaniasis worldwide

Natural product based leads to fight against leishmaniasis

 Review Article

Bioorganic & Medicinal Chemistry,Volume 22, Issue 1, 1 January 2014, Pages 18–45

Nisha Singh, Bhuwan B. Mishra, Surabhi BajpaiRakesh K. Singh, Vinod K. Tiwari
Molecular Immunology Laboratory, Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India , Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India 

http://www.sciencedirect.com/science/article/pii/S0968089613009887, 

VARANASI INDIA