NAPAZIMONE

 

Napazimone

https://newdrugapprovals.org/2026/02/17/napazimone/

Anthony Melvin Crasto AfricurePharma Row2Tech Anax AdvectProc Niper-G

Mevrometostat

 

Mevrometostat

https://newdrugapprovals.org/2026/02/10/mevrometostat/

Anthony Melvin Crasto AfricurePharma Row2Tech Anax AdvectProc Niper-G

Fanregratinib

 

Fanregratinib

https://newdrugapprovals.org/2026/01/23/fanregratinib/

Anthony Melvin Crasto AfricurePharma Row2Tech Anax AdvectProc Niper-G

Enrupatinib

 Enrupatinib

https://newdrugapprovals.org/2026/01/20/enrupatinib/

Anthony Melvin Crasto AfricurePharma Row2Tech Anax AdvectProc Niper-G

Talogreptide mesaroxetan

 

link

Talogreptide mesaroxetan

https://newdrugapprovals.org/2025/12/10/talogreptide-mesaroxetan/

BEXICASERIN

 

Bexicaserin

https://newdrugapprovals.org/2025/04/15/bexicaserin/

Photo-organocatalytic synthesis of acetals from aldehydes

Abstract

A mild and green photo-organocatalytic protocol for the highly efficient acetalization of aldehydes has been developed. Utilizing thioxanthenone as the photocatalyst and inexpensive household lamps as the light source, a variety of aromatic and aliphatic aldehydes have been converted into acyclic and cyclic acetals in high yields. The reaction mechanism was extensively studied

Photo-organocatalytic synthesis of acetals from aldehydes

 

Nikolaos F. Nikitas,^a  Ierasia Triandafillidi^a  and  Christoforos G. Kokotos*^a 

 Author affiliations

*Corresponding authors

^aLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece
E-mail:ckokotos@chem.uoa.gr

https://pubs.rsc.org/en/Content/ArticleLanding/2019/GC/C8GC03605E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

(3,3-Dimethoxypropyl)benzene (2a)6
Colorless oil; 95% yield; 1H NMR (200 MHz, CDCl3) δ: 7.33-7.18 (5H, m, ArH), 4.37 (1H, t, J = 5.8 Hz, OCH), 3.33 (6H, s, 2 x OCH3), 2.68 (2H, t, J = 7.6 Hz, CH2), 1.98- 1.87 (2H, m, CH2); 13C NMR (50 MHz, CDCl3) δ: 141.8, 128.4, 125.9, 103.7, 52.8, 34.0, 30.8; MS (ESI) m/z 181 [M+H]+ .
6. Q. Zhou, T. Jia. X.-X. Li, L. Zhou, C.-J. Li, Y. S. Feng, Synth. Commun., 2018, 48, 1068.

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2,3-Dihydrobenzofuran

• CAS Number 496-16-2
    
 
• Empirical Formula (Hill Notation) C₈H₈O
    
 
• Molecular Weight 120.15
•  Beilstein Registry Number 111928
    

http://www.rsc.org/suppdata/gc/c4/c4gc01822b/c4gc01822b1.pdfhttp://www.rsc.org/suppdata/gc/c4/c4gc01822b/c4gc01822b1.pdf


1H NMR

MASS

IR

UV

1H NMRPREDICT

13C NMR PREDICT

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A green route for methanol carbonylation

A green route for methanol carbonylation

Catal. Sci. Technol., 2017, Advance Article
DOI: 10.1039/C7CY01621B, Paper

Youming Ni, Lei Shi, Hongchao Liu, Wenna Zhang, Yong Liu, Wenliang Zhu, Zhongmin Liu
Halide-free and noble metal-free pyridine-modified H-mordenites exhibit high stability and selectivity in methanol carbonylation to acetic acid.

http://pubs.rsc.org/en/Content/ArticleLanding/2017/CY/C7CY01621B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fcy+%28RSC+-+Catalysis+Science+%26+Technology+latest+articles%29#!divAbstract

A green route for methanol carbonylation

Youming Ni,^ab  Lei Shi,^ab  Hongchao Liu,^ab  Wenna Zhang,^abc  Yong Liu,^ab  Wenliang Zhu*^ab  and Zhongmin Liu*^ab 

 Author affiliations

*Corresponding authors

^aNational Engineering Laboratory for Methanol to Olefins, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
E-mail: wlzhu@dicp.ac.cn, liuzm@dicp.ac.cn

^bDalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, PR China

^cUniversity of Chinese Academy of Sciences, Beijing 100049, PR China

Abstract

Acetic acid is one of the most important bulk commodity chemicals and is currently manufactured by methanol carbonylation reactions with rhodium or iridium organometallic complexes and halide-containing promoters named Monsanto or BP Cativa™ homogeneous processes, respectively. Developing a halide-free catalyst and a heterogeneous process for methanol carbonylation is of great importance and has recently attracted extensive research attention. Here, we report a green route for direct synthesis of acetic acid via vapor-phase carbonylation of methanol with a stable, selective, halide-free, and noble metal-free catalyst based on pyridine-modified H-mordenite zeolite. Methanol conversion and acetic acid selectivity can reach up to 100% and 95%, respectively. Only little deactivation is observed during the 145 hour reaction.

 

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Endo-4,7-bis(hydroxymethyl)hexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione (endo-4,7- bis(hydroxymethyl)norcantharimide)

Endo-4,7-bis(hydroxymethyl)hexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione (endo-4,7- bis(hydroxymethyl)norcantharimide), 4 (method A)

Endo-4,7-bis(hydroxymethyl)norcantharimid-5-ene (120 mg, 0.53 mmol) was dissolved in water (3 mL), Pd/C 10% was added (15 mg) and reaction mixture was placed under hydrogen atmosphere for 8 h at 24 °C. Catalyst was filtered off and washed thoroughly with water (3 × 3 mL), filtrate was evaporated under reduced pressure. Target compound 4 was obtained as white solid, yield 87% (110 mg).

1H NMR (D2O) = 3.76 (s, 4H), 3.46 (s, 2H), 1.61-1.72 (m, 4H);

1H NMR (DMSO-d6) = 11.10 (s, 1H), 5.08 (s, 2H), 3.66 (s, 4H), 3.37 (s, 2H), 1.71 (m, 2H), 1.49 (m, 2H);

13C NMR (D2O) = 179.0, 88.8, 60.7, 52.3, 27.0 ppm.

m/z HRMS (ESI) Calcd. for C10H13NO5 [M+Na]: 250.0686. Found 250.0696.

Efficient route for the construction of polycyclic systems from bioderived HMF 

Green Chem., 2017, Advance Article
DOI: 10.1039/C7GC02211E, Paper

F. A. Kucherov, K. I. Galkin, E. G. Gordeev, V. P. Ananikov
Efficient one-pot synthesis of tricyclic compounds from biobased 5-hydroxymethylfurfural (HMF) is described using a [4 + 2] cycloaddition reaction.

Efficient route for the construction of polycyclic systems from bioderived HMF

F. A. Kucherov,^a  K. I. Galkin,^a  E. G. Gordeev^a  and  V. P. Ananikov*^a 

 Author affiliations

*Corresponding authors

^aZelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky pr. 47, Moscow 119991, Russia
E-mail: val@ioc.ac.ru
Web: http://AnanikovLab.ru

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Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions

Green Chem., 2017, Advance Article
DOI: 10.1039/C7GC00657H, Paper

Nelly Ntumba Tshibalonza, Jean-Christophe M. Monbaliu
Highly selective flash deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions.

Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions

Ms. Nelly Tshibalonza Ntumba

Nelly Tshibalonza was born in 1983 in Kinshasa, Congo. She received her diploma degree in Chemistry in 2006 from the University of Kinshasa. She is currently a fellow of the Belgian Technical Cooperation and is preparing a Ph.D. thesis on the development of catalytic methods to enhance the value of renewable raw materials.

E-mail: nel.tshibalonza@student.ulg.ac.be
Telephone: +32 (0)4 366-3493

http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC00657H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions

Nelly Ntumba Tshibalonzaa  and  Jean-Christophe M. Monbaliu*a 

 Author affiliations

*Corresponding authors

aCenter for Integrated Technology and Organic Synthesis, Department of Chemistry, University of Liège, B-4000 Liège (Sart Tilman), Belgium
E-mail: jc.monbaliu@ulg.ac.be

Abstract

The deoxydehydration (DODH) of glycerol towards allyl alcohol was revisited under continuous-flow conditions combining a microfluidic reactor setup and a unique reactive dynamic feed solution approach. Short reaction times, high yield and excellent selectivity were achieved at high temperature and moderate pressure in the presence of formic acid, triethyl orthoformate, or a combination of both. Triethyl orthoformate appeared as a superior reagent for the DODH of glycerol, with shorter reaction times, lower reaction temperatures and more robust conditions. In-line IR spectroscopy and computations provided different perspectives on the unique reactivity of glycerol O,O,O-orthoesters.

JC M. Monbaliu, PhD.
Lecturer
Department of Chemistryjc.monbaliu@ulg.ac.be
t +32 (0) 4 366 35 10

Jean-Christophe M. Monbaliu

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2-Methoxy-4-propylphenol

 

2-Methoxy-4-propylphenol

2-Methoxy-4-propylphenol
1H NMR (400 Mhz, CDCl3) δ (ppm): 6.83 (1H,d, J = 7.8 Hz), 6.68 (2H, d, J = 7.4 Hz), 5.47 (1H, s), 3.79 (3H, s), 2.52 (2H, t, J =7.6 Hz), 1.61 (2H, sext, J = 7.5 Hz) 0.94 (3H, t, J = 7.3 Hz).

13C NMR (100 MHz, CDCl3) δ (ppm) 146.4, 143.6,134.7, 121.0, 114.2, 111.1, 55.9, 37.8, 24.9, 13.8.

HRMS (ESI-TOF) m/z: [M + H]+ calculated for C10H15O2:167.1067; found: 167.1064.

DOI: 10.1021/acs.oprd.6b00441

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Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Green Chem., 2017, Advance Article
DOI: 10.1039/C6GC03355E, Communication

Pei-Zhi Zhang, Jian-An Li, Ling Zhang, Adedamola Shoberu, Jian-Ping Zou, Wei Zhang
A method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely. The product was separated by crystallization and the byproducts were recovery by distillation

http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C6GC03355E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Pei-Zhi Zhang,^a   Jian-An Li,^a   Ling Zhang,^a  Adedamola Shoberu,^a   Jian-Ping Zou*^a and  Wei Zhang*^b  

*

Corresponding authors

^a

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Soochow University, 199 Renai Street, Suzhou, China
 E-mail: jpzou@suda.edu.cn

^b

Centre for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, USA
 E-mail: wei2.zhang@umb.edu

Green Chem., 2017, Advance Article

DOI: 10.1039/C6GC03355E

A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.


2,6-diphenyl-5-methylpyrimidinone

Colorless solid, mp 258−260 °C, 73% yield (191 mg).

1H NMR (400 MHz, DMSO-d6): δ 12.85 (s, 1H), 8.17 (d, J = 7.1 Hz, 2H), 7.68 (d, J = 6.6 Hz, 2H), 7.53 (dd, J = 14.3, 6.8 Hz, 6H), 2.10 (s, 3H).

13C NMR (101 MHz, CDCl3): δ 161.15, 152.97, 138.68, 132.26, 131.62, 129.11, 129.02, 128.86, 128.15, 127.45, 119.09, 12.65.

 HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H15N2O 263.1184, found 263.1194.





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Improving the efficiency of the Diels-Alder process by using flow chemistry and zeolite catalysis

• Improving the efficiency of the Diels-Alder process by using flow chemistry and zeolite catalysis
• Green Chem., 2017, Advance Article
  DOI: 10.1039/C6GC02334G, Paper

  S. Seghers, L. Protasova, S. Mullens, J. W. Thybaut, C. V. Stevens
  The industrial application of the Diels-Alder reaction for the synthesis of (hetero)cyclic compounds constitutes an important challenge. To tackle the reagent instability problems and corresponding safety issues, the use of a high-pressure and zeolite catalysed microreactor process is presented.

The industrial application of the Diels–Alder reaction for the atom-efficient synthesis of (hetero)cyclic compounds constitutes an important challenge. Safety and purity concerns, related to the instability of the polymerization prone diene and/or dienophile, limit the scalability of the production capacity of Diels–Alder products in a batch mode. To tackle these problems, the use of a high-pressure continuous microreactor process was considered. In order to increase the yields and the selectivity towards the endo-isomer, commercially available zeolites were used as a heterogeneous catalyst in a microscale packed bed reactor. As a result, a high conversion (≥95%) and endo-selectivity (89:11) were reached for the reaction of cyclopentadiene and methyl acrylate, using a 1:1 stoichiometry. A throughput of 0.87 g h⁻¹during at least 7 h was reached, corresponding to a 3.5 times higher catalytic productivity and a 14 times higher production of Diels–Alder adducts in comparison to the heterogeneous lab-scale batch process. Catalyst deactivation was hardly observed within this time frame. Moreover, complete regeneration of the zeolite was demonstrated using a straightforward calcination procedure

Improving the efficiency of the Diels–Alder process by using flow chemistry and zeolite catalysis

S. Seghers,^a   L. Protasova,^b   S. Mullens,^b  J. W. Thybaut^c and   C. V. Stevens*^a  

*

Corresponding authors

^a

SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
E-mail: chris.stevens@ugent.be

^b

VITO, Vlaamse Instelling voor Technologisch Onderzoek, Boeretang 200, 2400 Mol, Belgium

^c

Laboratory for Chemical Technology, Department of Chemical Engineering and Technical Chemistry, Faculty of Engineering and Architecture, Ghent University, Technologiepark 914, 9052 Ghent, Belgium

Green Chem., 2017, Advance Article

DOI: 10.1039/C6GC02334G
http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C6GC02334G?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

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