Continuous Flow Synthesis of Organic Electronic Materials – Case Studies in Methodology Translation and Scale-up

 Continuous Flow Synthesis of Organic Electronic Materials – Case Studies in Methodology Translation and Scale-up
 Helga Seyler , Wallace W. H. Wong et al

Australian Journal of Chemistry - http://dx.doi.org/10.1071/CH12406
Submitted: 1 September 2012  Accepted: 3 October 2012   Published online: 19 November 2012

 

Continuous flow chemistry was applied for the derivatization of alkylthiophene building blocks. The advantages of reaction automation and scale-up were demonstrated for selective lithiation-borylation and Knoevenagel condensation of thiophene derivatives. These synthetic approaches allow facile and rapid access to monomer and dyes for organic electronic applications.
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 http://www.publish.csiro.au/paper/CH12406.htm     copy paste link

Reduction of Sulfonylimines with Raney Nickel

Reduction of Sulfonylimines with Raney Nickel

José Luis García Ruano, José A. Fernández-Salas, M. Carmen Maestro & Alejandro Parra
pages 198-207

• DOI:10.1080/00397911.2011.594974
• http://www.tandfonline.com/doi/abs/10.1080/00397911.2011.594974   copy paste link

Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry,Volume 43, Issue 2, 2013  advance article                   

Raney-Ni/EtOH reduction of different N-sulfonylimines provides a new entry for synthesizing sulfonamides in good yields under mild conditions. This protocol, which does not require additional hydrogen, constitutes a cheap, safe, and easy-to-handle alternative procedure to prepare α-branched sulfonamides.

Synthesis of Enantiomerically Enriched α-Bromonitriles from Amino Acids

Synthesis of Enantiomerically Enriched α-Bromonitriles from Amino Acids

Najeh Tka, Jamil Kraïem & Béchir Ben Hassine
pages 735-743, DOI:10.1080/00397911.2011.608142

http://www.tandfonline.com/doi/abs/10.1080/00397911.2011.608142

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Two methods were investigated for the preparation of six chiral α-bromonitriles with different optic purities. The nitrous deamination of amino acids gives α-bromoacids, which react with chlorosulfonyl isocyanate followed by triethylamine to afford α-bromonitriles with moderate enantiomeric excess. However, the dehydration of corresponding α-bromoamids using thionyl chloride gives α-bromonitriles with good enantiomeric excess up to 94%. The use of phosphoryl chloride instead of thionyl chloride results in more than 30% racemization as determined by high-performance liquid chromatograpic analysis.

J. Iran. Chem. Soc., Vol. 8, No. Suppl., February 2011, pp. S119-S128.

http://www.ics-ir.org/jics/archive/v8/S1/Articles/pdf/JICS-8-S1-Article-13.pdf
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Synthesis of Quinolines Using Nano-Flake ZnO as a New Catalyst under Solvent-Free Conditions

M. Hosseini-Sarvari^, Department of Chemistry, College of Science, Shiraz University, Shiraz, 71454, Iran

     Catalytic activity of nano-flake ZnO for synthesis of quinoline derivatives and their related polyheterocycles under solvent-free conditions has been studied. Nano-flake ZnO has been successfully synthesized by conventional heating of a solution approach using ZnOAc.2H₂O and Urea. This method is simple, cost-effective, and environmentally benign and the catalyst can be reused for several times.

Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade

Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade,  Heiner Eckert

Molecules 2012, 17(1), 1074-1102; doi:10.3390/molecules17011074

http://www.mdpi.com/1420-3049/17/1/1074   copy paste on browser

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 A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses as well as use of various forms of energy as microwave and ultrasonic irradiation are examined and discussed.

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Progress in Microwave-Aided Chemical Synthesis

Progress in Microwave-Aided Chemical Synthesis

Hani Mutlak A. Hassan ^{A B}, Steve Harakeh ^A, Kaltoom A. Sakkaf ^A and Iuliana Denetiu <sup>A

A</sup> King Fahd Medical Research Centre, King Abdulaziz University, PO Box 80216, Jeddah 21589, Kingdom of Saudi Arabia. ^B Corresponding author. Email: hmahassan@kau.edu.sa

Australian Journal of Chemistry - http://dx.doi.org/10.1071/CH12366
Submitted: 5 August 2012  Accepted: 16 September 2012   Published online: 29 October 2012

 LINK IS
 http://www.publish.csiro.au/paper/CH12366.htm



The continuing use of microwave (µwave) energy in chemical synthesis has been impressive over the past decade, with many reports incorporating µwave-based reactions. Two of the major benefits of using µwave heating are the remarkable decrease in reaction times and often high yield of products in comparison with classical heating, an ideal technology for synthetic chemists. Herein, we highlight some exciting examples of its recent utility in organic, medicinal, and natural product synthetic endeavours.