Cucurbiturils , molecular container that can encapsulate drug molecules and increase the solubility of drugs

Giving drug dropouts a new lease of life
Researchers in the US have designed a molecular container that can encapsulate drug molecules and increase their solubility - in one case by almost 3000 times. The new container appears to have low toxicity and can be built from readily available reagents. The finding opens the possibility of re-testing drug candidates that failed because they were insufficiently soluble or improving existing low-solubility drugs.


D Ma et al, Nat. Chem., 2012, DOI: 10.1038/nchem.1326 

An Efficient Asymmetric Synthesis of Manzacidin C

"An Efficient Asymmetric Synthesis of Manzacidin C" Tran, K.; Lombardi, P. J.; Leighton, J. L.
by 


James L. Leighton


Org. Lett. 2008, 10, 3165-3167. [Link] 





http://pubs.acs.org/doi/abs/10.1021/ol8011869

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Imidazole derivatives: A comprehensive survey of their recognition properties

Pedro Molina ,  Alberto Tárraga and Francisco Otón

Affiliation Information

1. Departamento de Química Orgánica; Universidad de Murcia; Campus de Espinardo, , Spain

Org. Biomol. Chem., 2012, 10, 1711-1724

DOI:10.1039/C2OB06808G

http://pubs.rsc.org/en/Content/ArticleLanding/2012/OB/C2OB06808G

Due to its amphoteric nature the imidazole ring can function as selective and effective anion and/or cation and even neutral organic molecules receptor system.

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THANKS AND REGARD'S
DR ANTHONY MELVIN CRASTO Ph.D

amcrasto@gmail.com

MOBILE-+91 9323115463

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molecules reacting