Paecilomycin B

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天然物有機化学研究室 の最近の論文目録で す。

●　Kiyomi Ohba and Masaya Nakata

"Total Synthesis of Paecilomycin B"

Kiyomi Ohba ^*†‡ and Masaya Nakata ^‡

^† Medicinal Chemistry Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan

^‡ Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

Org. Lett., 2015, 17 (12), pp 2890–2893

DOI: 10.1021/acs.orglett.5b00983

Publication Date (Web): May 4, 2015

*E-mail: ohba.kiyomi@mf.mt-pharma.co.jp.

 Starting from the glucose-derived δ-lactone and the functionalized aryl bromide, the first total synthesis of naturally occurring paecilomycin B was achieved via functionalized aryl-β-C-glycoside synthesis using 2,4,6-triisopropylphenyllithium under Barbier-type reaction conditions and ring-closing metathesis as the key steps.

 http://pubs.acs.org/doi/full/10.1021/acs.orglett.5b00983

 

 

 

 

 

 

 


 

 

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