C–C Coupling Repertoire Grows ... Organic Synthesis: Reaction eases addition of chiral carbon centers to aryl groups

 

REVIVAL

This new reaction combines chiral secondary and tertiary boronic esters (left) with lithiated aryls to form intermediates that rearrange upon electrophile addition, yielding aryl-alkyl coupling products.

The revival of a nearly 50-year-old technique for forming carbon-carbon bonds may help ease the synthesis of aryl derivatives, such as drug candidates.

Varinder K. Aggarwal and coworkers at the University of Bristol, in England, have taken a venerable but neglected synthesis called Zweifel olefination and made it new again (Nat. Chem. 2014, DOI: 10.1038/nchem.1971).

C–C Coupling Repertoire Grows

Organic Synthesis: Reaction eases addition of chiral carbon centers to aryl groups

 http://cen.acs.org/articles/92/i24/CC-Coupling-Repertoire-Grows.html
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http://cen.acs.org/articles/92/i24/CC-Coupling-Repertoire-Grows.html


 BRAZIL WORLDCUP WEEK 2014