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Sunday 16 March 2014

An efficient Cu(II)-bis(oxazoline)-based polymer immobilised ionic liquid phase catalyst for asymmetric carbon-carbon bond formation

An efficient Cu(II)-bis(oxazoline)-based polymer immobilised ionic liquid phase catalyst for asymmetric carbon-carbon bond formation

Green Chem., 2014, 16,1470-1479
DOI: 10.1039/C3GC41378K, Paper
Simon Doherty, Julian G. Knight, Jack R. Ellison, Peter Goodrich, Leanne Hall, Christopher Hardacre, Mark J. Muldoon, Soomin Park, Ana Ribeiro, Carlos Alberto Nieto de Castro, Maria Jose Lourenco, Paul Davey
Asymmetric carbon-carbon bond forming reactions were catalysed by heterogeneous copper(II)-bis(oxazoline)-based PIILP systems.


The asymmetric Diels–Alder reaction between N-acryloyloxazolidinone and cyclopentadiene and the Mukaiyama-aldol reaction between methylpyruvate and 1-phenyl-1-trimethylsilyloxyethene have been catalysed by heterogeneous copper(II)-bis(oxazoline)-based polymer immobilised ionic liquid phase (PIILP) systems generated from a range of linear and cross linked ionic polymers. In both reactions selectivity and ee were strongly influenced by the choice of polymer. A comparison of the performance of a range of Cu(II)-bis(oxazoline)-PIILP catalyst systems against analogous supported ionic liquid phase (SILP) heterogeneous catalysts as well as their homogeneous counterparts has been undertaken and their relative merits evaluated.

Saturday 15 March 2014

Free Download Analysis and Purification Methods in Combinatorial Chemistry

Free Download Analysis and Purification Methods in Combinatorial Chemistry edited by Bing Yan


http://chemistry.com.pk/books/analysis-and-purification-methods-in-combinatorial-chemistry/
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Tuesday 11 March 2014

One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor


Figure 1: Microwave flow reactor for the Bohlmann–Rahtz synthesis of pyridine 2b.

 read at
http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-9-232 

The Bohlmann–Rahtz pyridine synthesis and the Hantzsch dihydropyridine synthesis can be carried out in a microwave flow reactor or using a conductive heating flow platform for the continuous processing of material. 
In the Bohlmann–Rahtz reaction, the use of a Brønsted acid catalyst allows Michael addition and cyclodehydration to be carried out in a single step without isolation of intermediates to give the corresponding trisubstituted pyridine as a single regioisomer in good yield. 
Furthermore, 3-substituted propargyl aldehydes undergo Hantzsch dihydropyridine synthesis in preference to Bohlmann–Rahtz reaction in a very high yielding process that is readily transferred to continuous flow processing.


Mark C. Bagley1Email of corresponding author, Vincenzo Fusillo2, Robert L. Jenkins2, M. Caterina Lubinu2 andChristopher Mason3
1Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex, BN1 9QJ, UK
2School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, UK
3CEM Microwave Technology Ltd, 2 Middle Slade, Buckingham, MK18 1WA, UK

This article is part of the Thematic Series "Chemistry in flow systems III".
Guest Editor: A. Kirschning
Beilstein J. Org. Chem. 2013, 9, 1957–1968.

Peering Inside Reactors Analytical Chemistry: Microspectroscopy tracks multistep process in action

Reaction scheme shows that a radiation-transparent microreactor allows researchers to look inside to monitor chemical reactions.

read all at

http://cen.acs.org/articles/92/i9/Peering-Inside-Reactors.html
 

It’s tough to get a detailed account of what’s going on inside catalytic chemical reactors while those workhorse pieces of equipment are running. If researchers could peer inside and monitor—at a microscopic level and in real time—the chemical reactions under way, they would gather a treasure trove of useful information. Engineers could then customize reactor geometry and dimensions and tailor the catalyst distribution to maximize energy efficiency, product output, and chemical selectivity.
That type of custom reactor engineering may be close at hand, thanks to a study conducted by researchers at the University of California, Berkeley, and Lawrence Berkeley National Laboratory.
The team designed a miniature reactor whose interior can be probed microscopically with infrared and X-ray beams. They used it to interrogate a multistep chemical reaction with extreme spatial resolution. The group pinpointed to within 15 μm the regions inside the reactor in which a flowing starting material was transformed to an initial product and then a final product. They correlated that information with the microscopic location, concentration, and chemical state of catalytic nanoparticles (J. Am. Chem. Soc. 2014, DOI: 10.1021/ja412740p).

Wednesday 5 March 2014

Larvicidal isoxazoles: Synthesis and their effective susceptibility towards Aedes aegypti larvae




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Larvicidal isoxazoles: Synthesis and their effective susceptibility towards Aedes aegypti larvae

 
 
Volume 21, Issue 4, 15 February 2013, Pages 940–947
Diana C.B. da Silva-Alves, Janaína V. dos Anjos, Nery N.M. Cavalcante, Geanne K.N. Santos, Daniela M.do A.F. Navarro, Rajendra M. Srivastava

 Twenty 3,5-disubstituted isoxazoles have been synthesized and tested against fourth instar Aedes aegyptilarvae. In the synthesis of title compounds, modifications have been made in the C-5 side-chain with a view to test their larvicidal activity. These isoxazoles have been obtained by 1,3-dipolar cycloaddition of arylnitrile oxides to terminal alkynes which furnished the desired products in 20% to 79% yields. A comparative study of the larvicidal activity between 3-(3-aryl-isoxazol-5-yl)-propan-1-ols and 3-(3-aryl-isoxazol-5-yl)-propionic acids clearly demonstrated that the latter compounds possess much better larvicidal activity than the former. We also tested two esters, viz., methyl 3-[3-(phenyl)-isoxazole-5-yl] propionate and methyl 3-[3-(4-chlorophenyl)-isoxazole-5-yl] propionate, where the latter presented an excellent larvicidal profile.

Thursday 27 February 2014

Catalyst Under Stress


 thumbnail image: Catalyst Under Stress
The oxidation of water to molecular oxygen is an important reaction in the frame of artificial photosynthesis, solar fuels, and a sustainable energy future. Iridium complexes have recently gained attention as effective precatalysts for this transformation. 

To gain deeper understanding of this process, Alceo Macchioni, University of Perugia, Italy, and colleagues aimed at intercepting the intermediates of the oxidative transformation of [Cp*Ir(bzpy)NO3] (Cp* = pentamethylcyclopentadienyl, bzpy = 2-benzoylpyridine), which is a competent catalyst for water oxidation.
read at
http://www.chemistryviews.org/details/ezine/5838331/Catalyst_Under_Stress.html

Thursday 13 February 2014

Make a macroring in half a day instead of several months

Inline image 4
Graphical abstract: Highly selective one-pot synthesis of H-bonded pentagon-shaped circular aromatic pentamers

Make a macroring in half a day instead of several months. 

INTRODUCTION
Macrocycles are not only esthetically pleasing, but they also can contain multiple functional groups. They are, however, difficult to synthesize. For example, preparing sterically crowded, circularly folded aromatic pentamer 1 required a months-long step-by-step process; and it was obtained in an overall yield of only ≈5%
(Qin, B., et al. Org. Lett. 2008, 10, 5127–5130).
The task is much easier now; it can be accomplished in half a day by using a synthetic route developed by H. Zeng and coauthors at the National University of Singapore, Guang Dong University of Technology (China), and Nanyang Technological University (Singapore).
 One-pot, multi-molecular macrocyclization allows the highly selective preparation of pentagon-shaped circular aromatic pentamers mediated by an inward-pointing continuous hydrogen-bonding network.

Graphical abstract: Highly selective one-pot synthesis of H-bonded pentagon-shaped circular aromatic pentamers

Inline image 1
The protocol is based on a hydrogen-bonding–assisted, one-pot macrocyclization reaction. In the presence of coupling reagent POCl3 and organic base Et3N, 3-amino-2-methoxybenzoic acid (2) undergoes self-amidation under mild conditions to give 1 in a high yield (46%) after a 12-h reaction time. The versatility of this highly selective macrocyclization reaction is illustrated by synthesizing derivatives of 2 with various substituents at the 2- and 5-positions. (Chem. Commun. 2011, 47, 5419–5421;


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Wednesday 29 January 2014

Saturday 11 January 2014

Studies of Removal of Indigo Caramine Dye from Water by Formaldehyde and Urea Treated Cellulosic Waste of Citrus reticulata Peels



 Citrus reticulata, Orange


Studies of Removal of Indigo Caramine Dye from Water by Formaldehyde and Urea Treated Cellulosic Waste of Citrus reticulata Peels



Asian J. Chem., 2014, 26(1), pp 43-47   |  DOI:10.14233/ajchem.2014.15305
Rabia Rehman*, Javaria Zafar and Hina Nisar
*Corresponding author: Fax: +92 42 99230998; 
Tel: +92 42 99230463, Ext: 870; E-mail: grinorganic@yahoo.com


The Citrus reticulata (orange) peels has been employed as adsorbents for removing inorganic and organic pollutants from wastewater extensively due to its low cost and eco-friendly nature. This research work concerns with the study of comparative removal of Indigo carmine dye from water using simple, formaldehyde and urea treated Citrus reticulata peels. The effect of adsorption parameters were investigated and maximum sorption capacity was obtained from Langmuir isotherm model at optimized conditions, i.e.: 5.90, 14.79 and 71.07 mg g-1 for simple, formaldehyde treated and urea treated Citrus reticulata peels, respectively. 

Feasibility of process is indicated by the values of separation factor, Gibb’s free energy and adsorption intensity ‘n’. The results of present study indicate that Citrus reticulata peels has inherited a lots of capacity for removing anthraquinone type of dyes, which can be further improved by treating with formaldehyde or urea in economical way.

Asian Journal of Chemistry

AN INTERNATIONAL PEER REVIEWED RESEARCH JOURNAL OF CHEMISTRY


Inst of Chem Eng , Univ of punjab, Pakistan




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INSTITUTE OF CHEMISTRY, UNIVERSITY OF THE PUNJAB LAHORE, PAKISTAN. (PUIC) - LAHORE

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University of the Punjab, Lahore, Pakistan-54590


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Thursday 9 January 2014

Natural product based leads to fight against leishmaniasis

image

The growing incidence of parasitic resistance against generic pentavalent antimonials, specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania control. Notwithstanding the two treatment alternatives, that is amphotericin B and miltefosine are being effectively used but their high cost and therapeutic complications limit their use in endemic areas. In the absence of a vaccine candidate, identification, and characterization of novel drugs and targets is a major requirement of leishmanial research. This review describes current drug regimens, putative drug targets, numerous natural products that have shown promising antileishmanial activity alongwith some key issues and strategies for future research to control leishmaniasis worldwide


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Natural product based leads to fight against leishmaniasis

 Review Article
Nisha Singh, Bhuwan B. Mishra, Surabhi BajpaiRakesh K. Singh, Vinod K. Tiwari
Molecular Immunology Laboratory, Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India , Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India 



VARANASI INDIA



Sunday 5 January 2014

New Organic Conjugated Molecules


A series of organic conjugated molecules containing 2,3-benzopyridiazine and thiophene derivatives has been synthesized