DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
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Saturday, 30 June 2012

A Review on some Indian Medicinal Plants for Antiulcer Activity

World Chemistry Departments

http://www-jmg.ch.cam.ac.uk/data/c2k/world.html  is the link  to
World Chemistry Departments

Tuesday, 26 June 2012

Recent Progress in the Use of Vilsmeier-Type Reagents


Recent Progress in the Use of Vilsmeier-Type Reagents

Organic Preparations and Procedures International: The New Journal for Organic Synthesis Volume 42, Issue 6, 2010                   

DOI:10.1080/00304948.2010.513911
Weike Sua, Yiyi Wenga, Ling Jianga, Yanyan Yanga, Linyao Zhaoa, Zhiwei Chena, Zhenhua Lia & Jianjun Lia pages 503-555
Available online: 15 Nov 2010
a  Weike Su, Key Laboratory of Pharmaceutical Engineering of
Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology,
Hangzhou 310014, P. R. China. E-mail: Pharmlab@zjut.edu.cn


FIND AN EXCELLENT REVIEW, IT IS FREE TO DOWNLOAD AT


Vilsmeier-Haack reaction mechanism

Friday, 15 June 2012

A New Bidesmoside Saponin from the Bark of Guaiacum officinale


A new bidesmosidic triterpene saponin, guaianin P was isolated from the stem bark of
Guaiacum officinale. Its structure was established as oleanolic acid 3-O-{α-L-rhamnopyranosyl-
(1→3)-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-α-L-arabinopyranoside}-28-O-
β-D-glucopyranosyl ester by spectroscopic and chemical

http://jcsp.org.pk/index.php/jcsp/article/viewFile/4177/2961  is the link
J. Chem.Soc.Pak., Vol. 34, No. 2, 2012 BY
NIKHAT SABA et al.,
RASHEEDA KHATOON, ZULFIQAR ALI and VIQAR UDDIN AHMAD
KARACHI
Guaianin P  is very nicely described
https://docs.google.com/viewer?url=http%3A%2F%2Fprr.hec.gov.pk%2FChapters%2F612-0.pdf
Above link gives the structures


-- 
ANTHONY MELVIN CRASTO
THANKS AND REGARD'S
DR ANTHONY MELVIN CRASTO Ph.D
MOBILE-+91 9323115463
GLENMARK SCIENTIST , NAVIMUMBAI, INDIA
web link
http://anthonycrasto.jimdo.com/
http://www.anthonymelvincrasto.yolasite.com/ 
http://www.slidestaxx.com/anthony-melvin-crasto-phd 

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Tuesday, 12 June 2012

High-Yielding Semi-Synthesis of an Artemisinin Precursor


High-Yielding Semi-Synthesis of an Artemisinin Precursor

“Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin” Westfall, P.J.; Pitera, D.J.; Lenihan, J.R.; Eng, D.; Woolard, F.X.; Regentin, R.; Horning, T.; Tsuruta, H.; Melis, D.J.; Owens, A.; Fickes, S.; Diola, D.; Benjamin, K.R.; Keasling, J.D.; Leavell, M.D.; McPhee, D.J.; Renninger, N.S.; Newman, J.D.; Paddon, C.J. Proc. Natl. Acad. Sci. U.S.A. 2012109, E111-E118. DOI: 10.1073/pnas.1110740109.
Malaria, caused mainly by the parasite Plasmodium falciparum, leads to nearly a million deaths and 250 million new infections each year. The sesquiterpene lactone endoperoxide artemisinin, derived from Artemisia annua, is very effective as an antimalarial drug, and widespread resistance hasn’t yet developed. Artemisinin is the only high-volume drug that is still isolated by extraction from its native plant producer in a low-yielding (around 10 μg per g plant material), resource-intensive process that uses volatile solvents (most commonly hexane).
Artemisia annua. 
As a result, supplies of the drug are short, and those who need it often can’t afford it. The development of new processes for artemisinin production would therefore advance both public health and green chemistry interests. Total synthesis of the drug hasn’t been considered as a viable alternative because of low yields, but a lot of effort has been directed toward developing semi-synthetic sources of artemisinin using a combination of microbial fermentation and chemical synthesis. Toward this end, theKeasling lab reported a few years ago that they had constructed a biosynthetic pathway for the artemisinin precursor amorpha-4,11-diene in yeast with yields of ~200 mg/L—already impressive given the complexity of the molecule. Amorphadiene synthase (ADS) comes from Artemisia annua; the rest of the genes are from yeast.